Introduction
Materials and methods
Retrieval of studies
Selection of the eligible studies
Data extraction
Statistical analysis
Results
Main characteristics of the included studies
Author | Year | Country | Population |
N
| Age | Male | Follow-up time (months) | Surgery or radiofrequency ablation | Metformin users/non-users | Pathological type | All cause death | KC-specific death |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Nayan et al. | 2016 | Canada | North American | 613 | 77.9a
| 367 (59.9%) | 272 (44.4%) | NR | Localized RCC | 409 | 194 (31.6%) | |
Hamieh et al. | 2016 | New York | North American | 4736 | 61.5b
| 3363 (71%) | 18.04b
| 3325 (70%) | 218/4337 | Metastatic RCC | NR | NR |
Nayan et al. | 2016 | Canada | North American | 158 | 63.9b
| 113 (71.5%) | 43b
| 158 (100%) | 82/76 | Localized RCC | NR | NR |
Keizman et al. | 2016 | Israel | Asian | 108 | 66.5a
| 70 (64.8%) | 25a
| 92 (85.2%) | 52/56 | Metastatic RCC | NR | NR |
Cheng et al. | 2016 | Singapore | Asian | 290 | 59.4a
| 131 (45.2%) | 59.1a
| 277 (95.5%) | 131/159 | Localized RCC | NR | 33 (11.4%) |
Cheng et al. | 2016 | Singapore | Asian | 100 | 61.9a
| 72 (72%) | 8.8b
| 41 (41%) | 53/47 | Metastatic RCC | NR | 79 (79%) |
Psutka et al. | 2014 | New York | North American | 283 | 67b
| 88 (31.1%) | 97.2b
| 283 (100%) | 83/200 | Localized RCC | NR | NR |
Hakimi et al. | 2013 | New York | North American | 784 | 62b
| 549 (70%) | 43.2b
| 55/729 | Localized RCC | NR | NR | |
Tseng et al. | 2015 | Taiwan | Asian | 247,252 | NR | 129,052 (52.2%) | 44,831 (18.1%) | 171,753/75,499 | NR | 1741 | NR |
Author | Survival analysis | Univariate HR (95% CI) |
P value | Multivariate HR (95% CI) |
---|---|---|---|---|
Nayan et al. | OS, CSS | OS: 0.99 (0.78–1.25) | OS: 1.09 (0.85–1.40) | |
CSS: 1.12 (0.80–1.55) | CSS: 1.25 (0.88–1.77) | |||
Hamieh et al. | OS, PFS | OS: 0.771 (0.566–1.049)a
| 0.098 | |
OS: 1.053 (0.837–1.324)b
| 0.6606 | |||
PFS: 0.905 (0.682–1.199)a
| 0.4858 | |||
PFS: 0.979 (0.806–1.189)b
| 0.8274 | |||
Nayan et al. | OS, CSS, DFS | OS: 0.86 (0.40–1.85) | 0.07 | |
CSS: 0.38 (0.08–1.86) | 0.23 | |||
DFS: 0.99 (0.36–2.74) | 0.98 | |||
Keizman et al. | OS, PFS | OS: 0.42 (0.26–0.69) | 0.001 | |
PFS: 0.71 (0.47–1.08) | 1 | |||
Cheng et al. | CSS, DFS | CSS: 0.23 (0.09–0.61) | 0.0028 | |
DFS: 0.47 (0.27–0.81) | 0.0058 | |||
Cheng et al. | CSS | CSS: 0.78 (0.50–1.23) | 0.29 | |
Psutka et al. | OS, CSS, DFS | OS: 0.58 (0.38–0.87) | 0.01 | |
CSS: 0.62 (0.32–1.21) | 0.16 | |||
DFS: 0.87 (0.51–1.48) | 0.6 | |||
Hakimi et al. | CSS, DFS | CSS: 0.76 (0.21–2.70) | 0.7 | |
DFS: 1.02 (0.59–1.74) | 1 | DFS: 1.22 (0.66–2.27) | ||
Tseng et al. | OS | OS: 0.279 (0.254–0.307) | <0.0001 |