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International Urology and Nephrology
Erschienen in: International Urology and Nephrology 11/2017

21.09.2017 | Nephrology - Original Paper

Prevalence of abdominal artery calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis

verfasst von: Zhihui Yao, Congxia Wang, Qiaona Zhang, Shan Ma, Baosong Gui, Chaoyang Duan

Erschienen in: International Urology and Nephrology | Ausgabe 11/2017

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Abstract

Purpose

To systematically determine the prevalence of abdominal artery calcification (AAC) in dialysis patients with end-stage renal disease (ESRD) and identify reasons for heterogeneity.

Methods

We searched PubMed, EMBASE, and Web of Science from database inception to March 2017. Cross-sectional or cohort (only used baseline data) studies reporting estimates of AAC prevalence in dialysis adult patients with ESRD were included. We performed a random-effects meta-analysis to generate pooled prevalence estimates. Subgroup analyses were used to compare differences within categorical variables (geographic region, AAC detection instruments, dialysis methods, study design, and sample size), and meta-regression analyses to assess the impact of continuous variables (participants’ age, duration of dialysis, and male proportion).

Results

A total of 44 studies with 9883 dialysis patients were included. The pooled prevalence for AAC was 68.5% (95% CI 63–73.9%). Subgroup analyses suggested that AAC prevalence varied significantly by geographical region and AAC detection instruments, not by dialysis methods, study design and sample size. Meta-regression analysis suggested that positive correlations were found between AAC prevalence and the age of participants as well as the male proportion (r = 1.01477, P = 0.002 and r = 2.034413, P = 0.01, respectively), but not with the duration of dialysis (P = 0.576).

Conclusion

The pooled and nearest estimate of AAC prevalence among dialysis patients was as high as 65%. Geographical region, AAC detection instruments, age of participants, and male proportion potentially lead to the high variance of the reported prevalence. Considering the high AAC prevalence, effective treatment for preventing vascular calcification in these patients is badly needed.
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Metadaten
Titel
Prevalence of abdominal artery calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis
verfasst von
Zhihui Yao
Congxia Wang
Qiaona Zhang
Shan Ma
Baosong Gui
Chaoyang Duan
Publikationsdatum
21.09.2017
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 11/2017
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-017-1685-9

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