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P2 receptor-mediated signaling in mast cell biology

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Abstract

Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.

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Abbreviations

ART:

ADP-ribosyltransferase

BMMC:

Bone marrow-derived mast cell

CBMC:

Cord blood mast cell

CNS:

Central nervous system

HLMC:

Human lung mast cell

IL:

Interleukin

MIP:

Macrophage inflammatory protein

NAD:

Nicotinamide adenine dinucleotide

NGF:

Nerve growth factor

oATP:

Oxidized ATP

OVA:

Ovalbumin

PAMPS:

Pathogen-associated molecular patterns

PKC:

Protein kinase C

RBL:

Rat basophilic leukemia

RANTES:

Regulated on activation, normal T cell expressed and secreted

SCF:

Stem cell factor

SP:

Substance P

TNFα:

Tumor necrosis factor α

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Acknowledgments

We are grateful to Dr. Zane Orinska for critical reading of the manuscript and to Annette Wallisch for editorial assistance.

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  1. Department of Immunology and Cell Biology, Research Center Borstel, 23845, Borstel, Germany

    Elena Bulanova & Silvia Bulfone-Paus

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  1. Elena Bulanova
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Correspondence to Elena Bulanova.

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Bulanova, E., Bulfone-Paus, S. P2 receptor-mediated signaling in mast cell biology. Purinergic Signalling 6, 3–17 (2010). https://doi.org/10.1007/s11302-009-9173-z

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