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Evaluation of Basis Function and Linear Least Squares Methods for Generating Parametric Blood Flow Images Using 15O-Water and Positron Emission Tomography

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Abstract

Purpose

Parametric analysis of 15O-water positron emission tomography (PET) studies allows determination of blood flow (BF), perfusable tissue fraction (PTF), and volume of distribution (V d) with high spatial resolution. In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated.

Procedures

Monte Carlo simulations were performed using typical perfusion values for brain, tumor, and heart. Clinical evaluation was performed using seven cerebral and 10 myocardial 15O-water PET studies. Basis function (BFM), linear least squares (LLS), and generalized linear least squares (GLLS) methods were used to calculate BF, PTF, or V d.

Results

Monte Carlo simulations and human studies showed that, for low BF values (<1 ml/min/ml), BF, PTF, and V d were calculated with accuracies better than 5% for all methods tested. For high BF (>2 ml/min/ml), use of BFM provided more accurate V d compared with (G)LLS.

Conclusions

In general, BFM provided the most accurate estimates of BF, PTF, and V d.

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Acknowledgements

The authors would like to thank the staff of the Department of Nuclear Medicine and PET Research involved in the production of 15O-water and acquisitions of the scans.

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Authors and Affiliations

  1. Department of Nuclear Medicine and PET Research, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands

    Ronald Boellaard PhD, Gert J. J. Luurtsema & Adriaan A. Lammertsma PhD

  2. Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands

    Paul Knaapen MD

  3. Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands

    Abraham Rijbroek MD

Authors
  1. Ronald Boellaard PhD
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  2. Paul Knaapen MD
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  3. Abraham Rijbroek MD
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  4. Gert J. J. Luurtsema
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  5. Adriaan A. Lammertsma PhD
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Correspondence to Ronald Boellaard PhD.

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Boellaard, R., Knaapen, P., Rijbroek, A. et al. Evaluation of Basis Function and Linear Least Squares Methods for Generating Parametric Blood Flow Images Using 15O-Water and Positron Emission Tomography. Mol Imaging Biol 7, 273–285 (2005). https://doi.org/10.1007/s11307-005-0007-2

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  • DOI: https://doi.org/10.1007/s11307-005-0007-2

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