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Standardized Uptake Value Atlas: Characterization of Physiological 2-Deoxy-2-[18F]fluoro-d-glucose Uptake in Normal Tissues

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Abstract

Purpose

The purpose of this study was to map the distribution of 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake in organs of patients with no known abnormalities in those tissues.

Procedures

We measured maximum and mean standardized uptake values (SUV) from FDG-positron emission tomography (PET)/computed tomography (CT) obtained from 98 patients (48 males and 50 females).

Results

Significant uptake (mean SUVmean > 2.5) was visualized in the cerebellum (8.0 ± 2.2), soft palate (2.92 ± 0.86), palatine tonsils (3.45 ± 1.4), lingual tonsils (3.08 ± 1.05), sublingual glands (3.3 ± 1.5), and testes (2.57 ± 0.56). Negative correlation for FDG uptake versus age was observed for the palatine tonsils, sublingual glands, and lungs (P < 0.001).

Conclusion

Better understanding of physiological uptake throughout the body is valuable for improved interpretive accuracy and should be useful for future semi-automated comparisons to a normal SUV database.

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Authors and Affiliations

  1. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, CA, USA

    Yingbing Wang, Edison Chiu, Jarrett Rosenberg & Sanjiv Sam Gambhir

  2. Department of Bioengineering, Stanford University, Stanford, CA, USA

    Sanjiv Sam Gambhir

  3. Bio-X Program, Department of Bioengineering, The James H. Clark Center, Stanford University School of Medicine, 318 Campus Drive, Clark E150, Stanford, CA, 94305-5427, USA

    Sanjiv Sam Gambhir

Authors
  1. Yingbing Wang
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  2. Edison Chiu
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  3. Jarrett Rosenberg
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  4. Sanjiv Sam Gambhir
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Correspondence to Sanjiv Sam Gambhir.

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Wang, Y., Chiu, E., Rosenberg, J. et al. Standardized Uptake Value Atlas: Characterization of Physiological 2-Deoxy-2-[18F]fluoro-d-glucose Uptake in Normal Tissues. Mol Imaging Biol 9, 83–90 (2007). https://doi.org/10.1007/s11307-006-0075-y

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  • DOI: https://doi.org/10.1007/s11307-006-0075-y

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