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β-Cell Mass Imaging with DTBZ Positron Emission Tomography: Is it Possible?

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References

  1. Ichise M, Harris PE (2010) Imaging of beta-cell mass and function. J Nucl Med 51:1001–1004

    Article  PubMed  CAS  Google Scholar 

  2. Singhal T, Ding YS, Weinzimmer D et al (2011) Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol 13:973–984

    Article  PubMed  Google Scholar 

  3. Goland R, Freeby M, Parsey R et al (2009) 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med 50:382–389

    Article  PubMed  CAS  Google Scholar 

  4. Normandin MD, Petersen KF, Ding YS et al (2012) In vivo imaging of endogenous pancreatic beta-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J Nucl Med 53(6):908–916

    Article  PubMed  CAS  Google Scholar 

  5. Blomberg BA, Moghbel MC, Alavi A (2012) PET imaging of beta-cell mass: is it feasible? Diabetes Metab Res Rev doi: 10.1002/dmrr.2314

  6. Kwee TC, Basu S, Saboury B et al (2011) Beta-cell imaging: opportunities and limitations. J Nucl Med 52:493

    Article  PubMed  Google Scholar 

  7. Basu S, Zaidi H, Houseni M et al (2007) Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states. Semin Nucl Med 37:223–239

    Article  PubMed  Google Scholar 

  8. Philippe MF, Benabadji S, Barbot-Trystram L et al (2011) Pancreatic volume and endocrine and exocrine functions in patients with diabetes. Pancreas 40:359–363

    Article  PubMed  CAS  Google Scholar 

  9. Alavi A, Newberg AB, Souder E, Berlin JA (1993) Quantitative analysis of PET and MRI data in normal aging and Alzheimer's disease: atrophy weighted total brain metabolism and absolute whole brain metabolism as reliable discriminators. J Nucl Med 34:1681–1687

    PubMed  CAS  Google Scholar 

  10. Fagerholm V, Mikkola KK, Ishizu T et al (2010) Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas. J Nucl Med 51:1439–1446

    Article  PubMed  CAS  Google Scholar 

  11. Tsao HH, Skovronsky DM, Lin KJ et al (2011) Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas. Nucl Med Biol 38:1029–1034

    Article  PubMed  CAS  Google Scholar 

  12. Eriksson O, Jahan M, Johnstrom P et al (2010) In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass. Nucl Med Biol 37:357–363

    Article  PubMed  CAS  Google Scholar 

  13. Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Krohn KA (2004) Non-invasive imaging of beta cell mass: a quantitative analysis. Diabetes Technol Ther 6:652–659

    Article  PubMed  Google Scholar 

  14. Cline GW, Zhao X, Jakowski AB, Soeller WC, Treadway JL (2011) Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic beta-cell mass. Biochem Biophys Res Commun 412:413–418

    Article  PubMed  CAS  Google Scholar 

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The authors declare that they have no conflict of interest.

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Correspondence to Abass Alavi.

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Blomberg, B.A., Eriksson, O., Saboury, B. et al. β-Cell Mass Imaging with DTBZ Positron Emission Tomography: Is it Possible?. Mol Imaging Biol 15, 1–2 (2013). https://doi.org/10.1007/s11307-012-0593-8

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  • DOI: https://doi.org/10.1007/s11307-012-0593-8

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