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28.06.2018 | Research Article

Near-Infrared Spatially Resolved Spectroscopy as an Indirect Technique to Assess Brown Adipose Tissue in Young Women

verfasst von: Francisco M. Acosta, Jörn Berchem, Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Juan M. A. Alcantara, Lourdes Ortiz-Alvarez, Takafumi Hamaoka, Jonatan R. Ruiz

Erschienen in: Molecular Imaging and Biology | Ausgabe 2/2019

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Abstract

Purpose

Near-infrared spectroscopy (NIRS) has recently been proposed as an indirect technique to assess brown adipose tissue (BAT) in young men. NIRS arises as a novel technique to avoid the limitations of the “gold-standard” 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]DG) positron emission tomography combined with X-ray computed tomography (PET/CT). The aim of this study was to examine the association between near-infrared spatially resolved spectroscopy (NIR_SRS) parameters and BAT volume and activity estimated by [¹⁸F]DG-PET/CT in 18 young healthy women.

Procedures

NIR_SRS parameters [tissue saturation index and concentrations of total haemoglobin, oxy-haemoglobin, and deoxy-haemoglobin] were continuously measured in the supraclavicular and forearm regions, in both warm and cold (2 h of personalised cold exposure) conditions. Then, the NIR_SRS data were analysed as an average of 5 min in 4 different periods: (i) warm period as the baseline record, (ii) cold period I, (iii) cold period II, and (iv) cold period III. The data were then correlated with BAT volume and activity (SUV_mean and SUV_peak) estimated by [¹⁸F]DG-PET/CT.

Results

There was no association between the NIR_SRS parameters in the supraclavicular region in warm conditions (no previous cold exposure) and BAT volume and activity (P > 0.05). Similarly, the cold-induced changes of the NIR_SRS parameters in the supraclavicular region were not associated with BAT volume and activity (P > 0.05).

Conclusions

NIR_SRS does not seem to be a valid technique to indirectly assess BAT in young healthy women. Further research is needed to validate this technique against other methods such as PET/CT using different radiotracers or magnetic resonance imaging.

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Titel: Near-Infrared Spatially Resolved Spectroscopy as an Indirect Technique to Assess Brown Adipose Tissue in Young Women
verfasst von: Francisco M. Acosta
Jörn Berchem
Borja Martinez-Tellez
Guillermo Sanchez-Delgado
Juan M. A. Alcantara
Lourdes Ortiz-Alvarez
Takafumi Hamaoka
Jonatan R. Ruiz
Publikationsdatum: 28.06.2018
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 2/2019
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-018-1244-5

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Near-Infrared Spatially Resolved Spectroscopy as an Indirect Technique to Assess Brown Adipose Tissue in Young Women

Abstract

Purpose

Procedures

Results

Conclusions

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Conclusions

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