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Impact of CPAP treatment on cardiac biomarkers and pro-BNP in obstructive sleep apnea syndrome

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Abstract

Objective

To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function.

Methods

Thirty-three consecutive patients with sleep apnea syndrome were analysed for serum pro-BNP and cardiac markers prior to and after 6 months of CPAP therapy.

Results

Twenty five patients had normal (83.3%) while remaining five (16.7%) revealed high pro-BNP values. We did not detect any significant difference between severity of obstructive sleep apnea syndrome and serum pro-BNP levels (p = 0.534). A statistically significant difference was not observed between basal and sixth-month creatine kinase (CK), creatine kinase-MB (CK-MB), troponin I, pro-BNP, aspartate transaminase (AST), and CK levels in patients with sleep apnea syndrome (p > 0.05).

Conclusion

Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro-BNP, CK, CK-MB, troponin I, and AST levels. Markers sensitive to ischemia could be preferred to evaluate effect of obstructive sleep apnea syndrome.

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Acknowledgment

We would like to thank to Meltem Akın and Eda İkbal for statistical evaluation of the study.

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Correspondence to Meral Uyar.

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Çifçi, N., Uyar, M., Elbek, O. et al. Impact of CPAP treatment on cardiac biomarkers and pro-BNP in obstructive sleep apnea syndrome. Sleep Breath 14, 241–244 (2010). https://doi.org/10.1007/s11325-009-0306-y

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  • DOI: https://doi.org/10.1007/s11325-009-0306-y

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