Abstract
Purpose
Advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic vascular complications. Recently, growing evidence has shown that AGEs could be involved in the pathogenesis of insulin resistance. It has also been suggested that circulating AGE are associated with insulin resistance in nondiabetic patients. This study investigated whether serum AGEs levels are associated with insulin resistance in nondiabetic patients with obstructive sleep apnea (OSA).
Methods
A total of 139 male nondiabetic patients with OSA were recruited for participation in the study. Serum AGE levels were examined using an enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR).
Results
There was a significant correlation between serum AGEs and the apnea-hypopnea index (AHI) (r = 0.281, p = 0.014), duration of SaO2 < 90 % (r = 0.267, p = 0.018), minimum SaO2 (r = −0.188, p = 0.046), high-sensitivity C-reactive protein (hsCRP) (r = 0.274, p = 0.012), and HOMA-IR (r = 0.303, p < 0.001). Multiple regression analysis showed that serum AGEs (p = 0.011), AHI (p = 0.024), waist circumference (p = 0.040), and hsCRP (p = 0.046) were independently associated with HOMA-IR (R 2 = 0.392). In addition, the strength of the correlation between serum AGEs and HOMA-IR was related to the severity of OSA.
Conclusions
The present study indicated that serum AGE levels were associated with insulin resistance in male nondiabetic patients with OSA. These findings suggest that AGEs may play a role in insulin resistance in OSA and may also be a biomarker for patients with OSA with high risk of developing type 2 diabetes.
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Acknowledgments
The authors would like to thank all patients who participated in this study. The study was supported by grants from the National Natural Science Funds of China (no. 81160105, 81360017) and the Jiangxi Provincial Natural Science Funds of China (no. 2010GZY0325, 20114BAB205006).
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The authors declare that they have no conflict of interest.
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Ji-xiong Xu and Wei Cai contributed equally to this work.
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Xu, Jx., Cai, W., Sun, Jf. et al. Serum advanced glycation end products are associated with insulin resistance in male nondiabetic patients with obstructive sleep apnea. Sleep Breath 19, 827–833 (2015). https://doi.org/10.1007/s11325-014-1100-z
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DOI: https://doi.org/10.1007/s11325-014-1100-z