Abstract
Purpose
Drug-induced sleep endoscopy (DISE) allows for direct airway observation in patients with obstructive sleep apnea. This study compared the safety profiles and efficacies of three regimens for DISE.
Methods
Sixty-six patients were randomly assigned to receive propofol alone (n = 22), a propofol-remifentanil combination (n = 22), or a dexmedetomidine-remifentanil combination (n = 22). Remifentanil was infused at a concentration of 1.5 ng·ml−1 in the propofol-remifentanil and dexmedetomidine-remifentanil groups, whereas saline was infused in the propofol group. The propofol and propofol-remifentanil groups received propofol at a starting concentration of 1.0 μg·ml−1, then 0.1 μg·ml−1 increments at 5 min intervals. The dexmedetomidine-remifentanil group received 1.0 μg·kg−1 loading dose of dexmedetomidine for 10 min and then 0.2 μg·kg−1·h−1 increments at 5 min intervals.
Results
The incidence of oxygen desaturation was significantly higher in the propofol-remifentanil group compared with that of the dexmedetomidine-remifentanil group (77 vs. 45 %, respectively, P = 0.024). Even with a maximum dose of dexmedetomidine (1.4 μg·kg−1·h−1), 50 % of the dexmedetomidine-remifentanil group did not reach sufficient sedation and required additional propofol. Cough reflex occurred in five patients of propofol group and in neither of the other groups (P = 0.004).
Conclusions
The propofol-remifentanil combination was associated with a higher incidence of desaturation. The dexmedetomidine-remifentanil combination was associated with inadequate sedation in one half of the patients, even though it produced less respiratory depression. Addition of remifentanil reduced the cough reflex.
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Cho, J.S., Soh, S., Kim, E.J. et al. Comparison of three sedation regimens for drug-induced sleep endoscopy. Sleep Breath 19, 711–717 (2015). https://doi.org/10.1007/s11325-015-1127-9
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DOI: https://doi.org/10.1007/s11325-015-1127-9