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Microalbuminuria in obstructive sleep apnea syndrome

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Abstract

Objectives

Microalbuminuria is an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to intermittent hypoxemia in patients with obstructive sleep apnea syndrome (OSAS). In this study, we investigated the prevalence and relationship of microalbuminuria with clinical and physiological parameters in patients with OSAS.

Method

Ninety-eight patients with OSAS and 26 nonapneic snoring subjects upon polysomnography were included in this study. The urinary albumin-to-creatinine ratio (UACR) was calculated according to a previously described formula. The severity index of chronic diseases was evaluated by using the modified cumulative illness rating scale (MCIRS). Insulin resistance (IR) method was analyzed by homeostasis assessment model (HOMA-IR). Subjective sleepiness was assessed using the Epworth sleepiness scale (ESS).

Results

Body mass index (BMI), MCIRS, and UACR were higher in patients with OSAS than nonapneic snoring subjects. In linear regression model, there was a negative relationship between UACR and minimal O2, and there was a significantly positive relationship between UACR and desaturation index.

Conclusion

Microalbuminuria may be seen in patients with OSAS, depending on the severity of disease and hypoxemia. Microalbuminuria in patients with OSAS should be examined in regular periods for risk of cardiovascular morbidity or mortality.

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Conflict of interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Faculty of Medicine, University of Kirikkale, 71100, Kirikkale, Turkey

    Emel Bulcun, Mehmet Ekici, Aydanur Ekici & Dilay Ahat Cimen

  2. Department of Biochemistry, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey

    Ucler Kisa

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  1. Emel Bulcun
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  2. Mehmet Ekici
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  3. Aydanur Ekici
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  4. Dilay Ahat Cimen
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  5. Ucler Kisa
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Correspondence to Emel Bulcun.

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Bulcun, E., Ekici, M., Ekici, A. et al. Microalbuminuria in obstructive sleep apnea syndrome. Sleep Breath 19, 1191–1197 (2015). https://doi.org/10.1007/s11325-015-1136-8

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  • DOI: https://doi.org/10.1007/s11325-015-1136-8

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