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16.02.2018 | Sleep Breathing Physiology and Disorders • Original Article

Cough hypersensitivity in patients with obstructive sleep apnea hypopnea syndrome

verfasst von: Cuiqin Shi, Siwei Liang, Xianghuai Xu, Qiang Chen, Lan Wang, Li Yu, Hanjing Lv, Zhongmin Qiu

Erschienen in: Sleep and Breathing | Ausgabe 1/2019

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Abstract

Purpose

The purpose of this study was to investigate cough hypersensitivity and its potential mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods

Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers received cough sensitivity test and induced sputum cytology. Cough thresholds C2 and C5 (the minimum of capsaicin inducing ≥ 2 and ≥ 5 coughs, respectively), total cell count, cell differentials and the levels of bradykinin, histamine, prostaglandin E₂, substance P, calcitonin gene-related peptide, pepsin, and interleukin-2 in the induced sputum detected by enzyme-linked immunosorbent assay were compared. The linear correlation between lgC2 and lgC5 and apnea hypopnea index, cell differentials, and inflammatory mediators in the induced sputum was calculated in OSAHS patients.

Results

OSAHS patients presented with a significant lower C2 and C5 (P < 0.01), increased lymphocyte but decreased macrophage and neutrophil proportions in the induced sputum (P < 0.01), and higher contents of substance P, calcitonin gene-related peptide and interleukin-2 (P < 0.01) but similar levels of bradykinin, pepsin, prostaglandin E₂, and histamine (P > 0.05) in the supernatant of induced sputum, when compared with simple snoring patients and healthy volunteers. However, theses variable were comparable between simple snoring patients and healthy volunteers (P > 0.05). Finally, lgC2 or lgC5 was negatively related to apnea hypopnea index, lymphocyte percentage, and the levels of substance P, calcitonin gene-related peptide or interleukin-2 in the sputum (P < 0.01). There was a positive linear correlation between lymphocyte percentage and interleukin-2 level in the induced sputum (r = 0.63, P = 0.00).

Conclusion

OSAHS patients have a predisposition of cough hypersensitivity associated with airway inflammation.

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Titel: Cough hypersensitivity in patients with obstructive sleep apnea hypopnea syndrome
verfasst von: Cuiqin Shi
Siwei Liang
Xianghuai Xu
Qiang Chen
Lan Wang
Li Yu
Hanjing Lv
Zhongmin Qiu
Publikationsdatum: 16.02.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 1/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1641-7

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Cough hypersensitivity in patients with obstructive sleep apnea hypopnea syndrome

Abstract

Purpose

Methods

Results

Conclusion

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