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Age and gender effects on submental motor-evoked potentials

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Abstract

It is not known whether there are age- and/or gender-related differences in magnitude of motor-evoked potentials (MEPs) of the submental muscles. Knowledge of this is important in investigations of neurophysiological aspects of swallowing. Forty healthy participants (20 males, 20 females; 20 young [21–35 years], 20 old [53–88 years]) were recruited. Surface electromyography (EMG) electrodes were placed at midline underlying the submental muscle group. Age- and gender-related differences were evaluated in two neurophysiologic measures of swallowing: MEPs stimulated by single-pulse transcranial magnetic stimulation (TMS) over the motor cortex and surface electromyography (sEMG) recorded from the same submental muscle group during non-stimulated swallows. The older participants had larger MEPs during saliva swallowing than the young participants (p = 0.04, d = 0.86). Conversely, the older participants had lower amplitude submental EMG activity during non-stimulated swallows (p = 0.045, d = 0.67). Gender had no significant effect on MEP magnitude and on submental activity during saliva swallowing. There were no effects of age or gender on MEP latencies. These findings suggest deterioration in muscle function with age in a sample of healthy adults presenting with functional swallowing. We speculate that muscular decline is partially ameliorated by increased cortical activity—i.e., increased submental MEPs—so as to preserve swallowing function in healthy older subjects. These findings emphasize the need for different reference points for evaluation of submental MEPs of different age groups.

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Acknowledgments

The work was supported by a research grant from Canterbury Medical Research Foundation.

Conflict of interest

The authors declare that there are no conflicts of interest.

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Author notes

  1. Oshrat Sella

    Present address: Department of Communication Sciences and Disorders, University of Haifa, Mount Carmel, 31905, Haifa, Israel

Authors and Affiliations

  1. New Zealand Brain Research Institute, 66 Stewart St, Christchurch, 8011, New Zealand

    Oshrat Sella, Richard D. Jones & Maggie-Lee Huckabee

  2. Department of Communication Disorders, University of Canterbury, Christchurch, 8140, New Zealand

    Oshrat Sella, Richard D. Jones & Maggie-Lee Huckabee

  3. Department of Psychology, University of Canterbury, Christchurch, 8140, New Zealand

    Richard D. Jones

  4. Department of Electrical & Computer Engineering, University of Canterbury, Christchurch, 8140, New Zealand

    Richard D. Jones

  5. Department of Medical Physics and Bioengineering, Christchurch Hospital, Christchurch, 8011, New Zealand

    Richard D. Jones

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  1. Oshrat Sella
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Correspondence to Oshrat Sella.

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Sella, O., Jones, R.D. & Huckabee, ML. Age and gender effects on submental motor-evoked potentials. AGE 36, 9735 (2014). https://doi.org/10.1007/s11357-014-9735-z

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