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01.10.2008 | Natural Medicine Note

Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

verfasst von: Adil Astulla, Kazumasa Zaima, Yosuke Matsuno, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2008

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Abstract

Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

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Titel: Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities
verfasst von: Adil Astulla
Kazumasa Zaima
Yosuke Matsuno
Yusuke Hirasawa
Wiwied Ekasari
Aty Widyawaruyanti
Noor Cholies Zaini
Hiroshi Morita
Publikationsdatum: 01.10.2008
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2008
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-008-0259-7

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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