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Journal of Natural Medicines

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01.01.2011 | Original Paper

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

verfasst von: Tomoko Akase, Tsutomu Shimada, Susumu Terabayashi, Yukinobu Ikeya, Hiromi Sanada, Masaki Aburada

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2011

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Abstract

Kaempferia parviflora Wall. Ex Baker (KP) has been used as a folk medicine in Laos and Thailand to lower blood glucose levels, improve blood flow, and increase vitality. This study investigated the preventive effects of KP on obesity and its downstream symptoms (various metabolic disorders) using Tsumura, Suzuki, Obese Diabetes (TSOD) mice, a multifactorial genetic disease animal model in which metabolic diseases develop spontaneously, similar to metabolic syndrome in humans, and Tsumura, Suzuki, Non-Obesity (TSNO) mice as the corresponding control mice. When feed that was mixed with KP (1 or 3%) was given ad libitum to TSOD and TSNO mice for 8 weeks, body weight increase, visceral fat accumulation, lipid metabolism abnormalities, hyperinsulinemia, glucose intolerance, insulin resistance, hypertension, and peripheral neuropathy were suppressed in TSOD mice, but no marked differences were observed in TSNO mice. Because KP had preventive effects on metabolic diseases, including antiobesity effects, only in obese animals, we propose that KP will be extremely valuable as a medicine or component of food in alternative health care.

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Titel: Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
verfasst von: Tomoko Akase
Tsutomu Shimada
Susumu Terabayashi
Yukinobu Ikeya
Hiromi Sanada
Masaki Aburada
Publikationsdatum: 01.01.2011
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2011
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-010-0461-2

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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