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Journal of Natural Medicines

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01.04.2014 | Original Paper

Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances

verfasst von: Masayoshi Arai, Chisu Han, Yoshi Yamano, Andi Setiawan, Motomasa Kobayashi

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2014

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Abstract

A new aaptamine class alkaloid, designated 2-methoxy-3-oxoaaptamine (1), together with seven known aaptamines (2–8) were isolated from a marine sponge of Aaptos sp. as anti-mycobacterial substances against active and dormant bacilli. The chemical structure of 1 was determined on the basis of spectroscopic analysis. Compound 1 was anti-mycobacterial against Mycobacterium smegmatis in both active growing and dormancy-inducing hypoxic conditions with a minimum inhibitory concentration (MIC) of 6.25 μg/ml, and compounds 2, 5, 6, and 7 showed anti-mycobacterial activities under hypoxic condition selectively, with MIC values of 1.5–6.25 μg/ml.

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Titel: Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances
verfasst von: Masayoshi Arai
Chisu Han
Yoshi Yamano
Andi Setiawan
Motomasa Kobayashi
Publikationsdatum: 01.04.2014
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2014
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-013-0811-y

Springer Medizin

Abstract

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