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Erschienen in: Forensic Toxicology 2/2017

24.03.2017 | Short Communication

Preventing misidentification of 25I-NBOH as 2C-I on routine GC–MS analyses

verfasst von: José Coelho Neto, Ana Flávia B. Andrade, Rogério Araújo Lordeiro, Yuri Machado, Mathieu Elie, Ettore Ferrari Júnior, Luciano Chaves Arantes

Erschienen in: Forensic Toxicology | Ausgabe 2/2017

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Abstract

25I-NBOH is a novel psychoactive substance (NPS) recently reported to have been found on blotter paper samples seized on the streets of Brazil, and used as a replacement for the NBOMes now scheduled in many countries. The presence of this NPS on the street market may go undetected, because the most widely and routinely utilised analytical technique for drug sample analyses is gas chromatography–mass spectrometry (GC–MS), which can misidentify 25I-NBOH (and indeed the other members of the NBOH series), because of its degradation into 2C-I (and corresponding 2C for the other members of the series) within the injector, unless a derivatization procedure is employed, which is often non-standard. While direct detection of 25I-NBOH under routine GC–MS conditions is still achieved, a slight adjustment in the standard GC–MS method, including shortening of the solvent delay window, was found to enable the detection of an additional peak due to 25I-NBOH degradation. Consequently, the presence of this secondary early chromatographic peak allowed for the distinction between 25I-NBOH and 2C-I using routine GC–MS without resorting to derivatization (or other analytical processes), thus preventing misidentification of 25I-NBOH as 2C-I.
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Metadaten
Titel
Preventing misidentification of 25I-NBOH as 2C-I on routine GC–MS analyses
verfasst von
José Coelho Neto
Ana Flávia B. Andrade
Rogério Araújo Lordeiro
Yuri Machado
Mathieu Elie
Ettore Ferrari Júnior
Luciano Chaves Arantes
Publikationsdatum
24.03.2017
Verlag
Springer Japan
Erschienen in
Forensic Toxicology / Ausgabe 2/2017
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-017-0362-0

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