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Nonocclusive mesenteric ischaemia: think about it

  • EMERGENCY RADIOLOGY
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Abstract

Nonocclusive mesenteric ischaemia (NOMI) is an acute mesenteric circulatory disorder that is not caused by an organic occlusion of blood vessels. It could involve all the abdominal parenchymas and viscera and the whole gastrointestinal tract (from the oesophagus to the rectum), insomuch that the involvement of the entire colon should be considered a distinctive tract in diagnosing this condition in respect of the occlusive forms of ischaemia. The aim of this article is to review the role of imaging in the diagnosis of NOMI and in particular its CT appearances. Recognition of the characteristic CT appearances and the variations associated with a reperfusion event may help in the accurate interpretation of CT in the diagnosis and management of NOMI.

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References

  1. Trompeter M, Brazda T, Remy CT et al (2002) Non-occlusive mesenteric ischemia: etiology, diagnosis, and interventional therapy. Eur Radiol 12:1179–1187

    Article  PubMed  Google Scholar 

  2. Ende N (1958) Infarction of the bowel in cardiac failure. N Engl J Med 258:879–881

    Article  CAS  PubMed  Google Scholar 

  3. Mazzei MA, Guerrini S, Cioffi Squitieri N et al (2014) Non-obstructive mesenteric ischemia after cardiovascular surgery: not so uncommon. Ann Thorac Cardiovsc Surg 20(3):253–255

  4. Kamimura K, Oosaki A, Sugahara S, Mori S (2008) Survival of three nonocclusive mesenteric ischemia patients following early diagnosis by multidetector row computed tomography and prostaglandin E1 treatment. Intern Med 47:2001–2006

    Article  PubMed  Google Scholar 

  5. Mitsuyoshi A, Obama K, Shinkura N et al (2007) Survival in nonocclusive mesenteric ischemia: early diagnosis by multidetector row computed tomography and early treatment with continuous intravenous high-dose prostaglandin E(1). Ann Surg 246:229–235

    Article  PubMed Central  PubMed  Google Scholar 

  6. Schoots IG, Koffeman GI, Legemate DA et al (2004) Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. Br J Surg 91:17–27

    Article  CAS  PubMed  Google Scholar 

  7. Reginelli A, Iacobellis F, Berritto D et al (2013) Mesenteric ischemia: the importance of differential diagnosis for the surgeon. BMC Surg 13(suppl 2):S51. doi:10.1186/1471-2482-13-S2-S51

    Article  PubMed Central  PubMed  Google Scholar 

  8. Mazzei MA, Guerrini S, Cioffi Squitieri N et al (2012) Diagnosis of acute mesenteric ischemia/infarction in the era of multislice CT. Recenti Prog Med 103:435–437

    PubMed  Google Scholar 

  9. Scaglione M, Grassi R, Pinto A et al (2004) Positive predictive value and negative predictive value of spiral CT in the diagnosis of closed loop obstruction complicated by intestinal ischemia. Radiol Med 107:69–77

    PubMed  Google Scholar 

  10. Bassiounty HS (1997) Nonocclusive mesenteric ischemia. Surg Clin North Am 77:319–326

    Article  Google Scholar 

  11. Cerqueira NF, Hussni CA, Yoshida WB (2005) Pathophysiology of mesenteric ischemia/reperfusion: a review. Acta Cir Bras 20:336–343

    PubMed  Google Scholar 

  12. Noffsinger A, Fenoglio-Preiser C, Maru D, Gilinsky N (2007) Gastrointestinal diseases. Atlas of nontumor pathology. ARP Press, Washington

    Google Scholar 

  13. Walker TG (2009) Mesenteric ischemia. Semin Interv Radiol 26:175–183. doi:10.1055/s-0029-1225662

    Article  Google Scholar 

  14. Mazzei MA, Guerrini S, Cioffi Squitieri N et al (2013) The role of US examination in the management of acute abdomen. Crit Ultrasound J 15(5 suppl 1):S6. doi:10.1186/2036-7902-5-S1-S6

    Article  Google Scholar 

  15. Mazzei MA, Cioffi Squitieri N, Guerrini S et al (2013) Sigmoid diverticulitis: US findings. Crit Ultrasound J 15(5 Suppl 1):S5. doi:10.1186/2036-7902-5-S1-S5

    Google Scholar 

  16. Kazui T, Yamasaki M, Abe K et al (2012) Non-obstructive mesenteric ischemia: a potentially lethal complication after cardiovascular surgery: report of two cases. Ann Thorac Cardiovasc Surg 18:56–60

    Article  PubMed  Google Scholar 

  17. Acosta S, Nilsson T (2012) Current status on plasma biomarkers for acute mesenteric ischemia. J Thromb Thrombolysis 33:355–361. doi:10.1007/s11239-011-0660-z

    Article  CAS  PubMed  Google Scholar 

  18. Matsumoto S, Sekine K, Funaoka H et al (2014) Diagnostic performance of plasma biomarkers in patients with acute intestinal ischaemia. Br J Surg 101:232–238. doi:10.1002/bjs.9331

    Article  CAS  PubMed  Google Scholar 

  19. Cakmaz R, Büyükaşık O, Kahramansoy N et al (2013) A combination of plasma DAO and citrulline levels as a potential marker for acute mesenteric ischemia. Libyan J Med 26(8):1–6. doi:10.3402/ljm.v8i0.20596

    Google Scholar 

  20. Evennett NJ, Petrov MS, Mittal A, Windsor JA (2009) Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World J Surg 33:1374–1383. doi:10.1007/s00268-009-0074-7

    Article  PubMed  Google Scholar 

  21. Moschetta M, Stabile Ianora AA, Pedote P et al (2009) Prognostic value of multidetector computed tomography in bowel infarction. Radiol Med 114:780–791

    Article  CAS  PubMed  Google Scholar 

  22. Reginelli A, Genovese E, Cappabianca S et al (2013) Intestinal ischemia: US-CT findings correlations. Crit Ultrasound J 15(5 Suppl 1):S7. doi:10.1186/2036-7902-5-S1-S7

    Article  Google Scholar 

  23. Furukawa A, Kanasaki S, Kono N et al (2009) CT diagnosis of acute mesenteric ischemia from various causes. AJR Am J Roentgenol 192:408–416

    Article  PubMed  Google Scholar 

  24. Mazzei MA, Mazzei FG, Marrelli D et al (2012) Computed tomographic evaluation of mesentery: diagnostic value in acute mesenteric ischemia. J Comput Assist Tomogr 36:1–7

    Article  PubMed  Google Scholar 

  25. Grassi R, Di Mizio R, Pinto A et al (2004) Serial plain abdominal film findings in the assessment of acute abdomen: spastic ileus, hypotonic ileus, mechanical ileus and paralytic ileus. Radiol Med 108:56–70

    PubMed  Google Scholar 

  26. Grassi R, Pinto A, Romano L et al (1997) Twenty-six consecutive patients with acute superior mesenteric infarction. Comparison of conventional radiology, ultrasonography, and computerized tomography. Radiol Med 93:699–703

    CAS  PubMed  Google Scholar 

  27. Siegelman SS, Sprayregen S, Boley SJ (1974) Angiographic diagnosis of mesenteric arterial vasoconstriction. Radiology 112:533–542

    Article  CAS  PubMed  Google Scholar 

  28. Boley SJ, Sprayregan S, Siegelman SS, Veith FJ (1977) Initial results from an aggressive roentgenological and surgical approach to acute mesenteric ischemia. Surgery 82:848–855

    CAS  PubMed  Google Scholar 

  29. Woodhams R, Nishimaki H, Fujii K et al (2010) Usefulness of multidetector-row CT (MDCT) for the diagnosis of non-occlusive mesenteric ischemia (NOMI): assessment of morphology and diameter of the superior mesenteric artery (SMA) on multi-planar reconstructed (MPR) images. Eur J Radiol 76:96–102

    Article  PubMed  Google Scholar 

  30. Nakamura Y, Urashima M, Toyota N et al (2013) Non-occlusive mesenteric ischemia (NOMI): utility of measuring the diameters of the superior mesenteric artery and superior mesenteric vein at multidetector CT. Jpn J Radiol. (Epub ahead of print)

  31. Oliva IB, Davarpanah AH, Rybicki FJ et al (2013) ACR appropriateness criteria® imaging of mesenteric ischemia. Abdom Imaging 38:714–719. doi:10.1007/s00261-012-9975-2

    Article  PubMed  Google Scholar 

  32. Lassandro F, di Santo Stefano ML, Maria Porto A, Grassi R, Scaglione M, Rotondo A (2010) Intestinal pneumatosis in adults: diagnostic and prognostic value. Emerg Radiol. (Epub ahead of print)

  33. Somma F, Berritto D, Iacobellis F et al (2013) 7T μMRI of mesenteric venous ischemia in a rat model: timing of the appearance of findings. Magn Reson Imaging 31:408–413. doi:10.1016/j.mri.2012.08.003

    Article  PubMed  Google Scholar 

  34. Balthazar EJ, Yen BC, Gordon RB (1999) Ischemic colitis: CT evaluation of 54 cases. Radiology 211:381–388

    Article  CAS  PubMed  Google Scholar 

  35. Mazzei MA, Guerrini S, Cioffi Squitieri N et al (2013) Magnetic resonance imaging: is there a role in clinical management for acute ischemic colitis? World J Gastroenterol 19:1256–1263. doi:10.3748/wjg.v19.i8.1256

    Article  PubMed Central  PubMed  Google Scholar 

  36. Saba L, Berritto D, Iacobellis F et al (2013) Acute arterial mesenteric ischemia and reperfusion: macroscopic and MRI findings, preliminary report. World J Gastroenterol 19:6825–6833. doi:10.3748/wjg.v19.i40.6825

    Article  PubMed Central  PubMed  Google Scholar 

  37. Berritto D, Somma F, Landi N et al (2011) Seven-Tesla micro-MRI in early detection of acute arterial ischaemia: evolution of findings in an in vivo rat model. Radiol Med 116:829–841

    Article  CAS  PubMed  Google Scholar 

  38. Romano S, Scaglione M, Gatta G et al (2004) Association of splenic and renal infarctions in acute abdominal emergencies. Eur J Radiol 50:48–58

    Article  PubMed  Google Scholar 

  39. Lassandro F, Scaglione M, Rossi G et al (2002) Portomesenteric vein gas: diagnostic and prognostic value. Emerg Radiol 9:96–99

    Article  PubMed  Google Scholar 

  40. Moschetta M, Telegrafo M, Rella L et al (2014) Multi-detector CT features of acute intestinal ischemia and their prognostic correlations. World J Radiol 6:130–138

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

The authors thank Ms. Julia Hassall for reviewing the English language, Dr. Susanna Guerrini for editorial assistance in the manuscript preparation and Dr. Nevada Cioffi Squitieri, Dr. Giusi Imbriaco and Dr. Francesco Giuseppe Mazzei for collecting the case history data.

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The authors declare no conflict of interest.

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Correspondence to Maria Antonietta Mazzei.

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Mazzei, M.A., Volterrani, L. Nonocclusive mesenteric ischaemia: think about it. Radiol med 120, 85–95 (2015). https://doi.org/10.1007/s11547-014-0460-6

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  • DOI: https://doi.org/10.1007/s11547-014-0460-6

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