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01.07.2015 | CHEST RADIOLOGY

Definitive intensity-modulated radiotherapy compared with definitive conventional radiotherapy in cervical oesophageal squamous cell carcinoma

verfasst von: Caineng Cao, Jingwei Luo, Li Gao, Guozhen Xu, Junlin Yi, Xiaodong Huang, Kai Wang, Shiping Zhang, Yuan Qu, Suyan Li, Jianping Xiao, Zhong Zhang

Erschienen in: La radiologia medica | Ausgabe 7/2015

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Abstract

Purpose

The authors compared definitive intensity-modulated radiotherapy (IMRT) with definitive conventional radiotherapy (2D-RT) in cervical oesophageal squamous cell carcinoma (CESCC).

Materials and methods

A total of 101 patients with CESCC treated with definitive radiotherapy from January 2001 to April 2012 were analysed. 37 patients were irradiated using 2D-RT, whereas 64 cases were treated using IMRT.

Results

The median follow-up time was 15.5 months for all the patients. For all patients, the overall 2-year local failure-free survival (LFFS), regional failure-free survival (RFFS), and overall survival (OS) rate was 67.4, 85.2 and 46.2 %, respectively. The 2-year LFFS rate and the 2-year RFFS rate in the IMRT group were higher than the 2D-RT group, although no statistically significant difference was observed in LFFS and RFFS. No statistically significant difference was observed in overall survival (OS) between the groups. Compared with 2D-RT, the rate of grade 3 dysphagia after radiotherapy was lower (6.3 vs. 8.1 %) and none had hypothyroidism requiring lifelong thyroxine replacement in the IMRT group. Matched-cases analysis did not show a statistical difference in terms of LFFS, RFFS and OS between the groups.

Conclusions

Although no statistically significant difference was observed in OS, LFFS and RFFS between the IMRT group and the 2D-RT group, the incidence of late toxicity declined using IMRT, thereby resulting in an improved therapeutic ratio for patients with CESCC.

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Titel: Definitive intensity-modulated radiotherapy compared with definitive conventional radiotherapy in cervical oesophageal squamous cell carcinoma
verfasst von: Caineng Cao
Jingwei Luo
Li Gao
Guozhen Xu
Junlin Yi
Xiaodong Huang
Kai Wang
Shiping Zhang
Yuan Qu
Suyan Li
Jianping Xiao
Zhong Zhang
Publikationsdatum: 01.07.2015
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 7/2015
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-015-0510-8

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Definitive intensity-modulated radiotherapy compared with definitive conventional radiotherapy in cervical oesophageal squamous cell carcinoma

Abstract

Purpose

Materials and methods

Results

Conclusions

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Abstract

Purpose

Materials and methods

Results

Conclusions

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