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01.07.2016 | ABDOMINAL RADIOLOGY

Comparison of retrospective PET and MRI-DWI (PET/MRI-DWI) image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases

verfasst von: Alessandro Stecco, Francesco Buemi, Alessia Cassarà, Roberta Matheoud, Gian Mauro Sacchetti, Alberto Arnulfo, Marco Brambilla, Alessandro Carriero

Erschienen in: La radiologia medica | Ausgabe 7/2016

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Abstract

Objectives

The aim of this study was to compare the accuracy of retrospective image fusion of PET/MRI-DWI with that of PET/CT and MRI-DWI alone in detecting metastatic lymph nodes in patients with cervical and endometrial carcinoma.

Materials and methods

Twenty-seven patients with endometrial (n = 14) and cervical (n = 13) cancer who had undergone preoperative MRI-DWI and PET/CT for staging were retrospectively evaluated. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PET/CT, MRI-DWI, and PET/MRI-DWI image fusion were calculated on a per-patient basis and on a per-node basis. Histopathological and follow-up imaging results were used as the gold standard.

Results

On a per-patient basis PET/MRI-DWI had the same sensitivity (87.5 %), specificity (84.2 %), diagnostic accuracy (85.1 %), PPV (70 %), and NPV (94.1 %) as PET-CT, but on a per-node basis PET/MRI-DWI showed better sensitivity (89 vs 70.2 %), specificity (91.6 vs 90.5 %), diagnostic accuracy (91.2 vs 87 %), PPV (68.7 vs 60.4 %), and NPV (97.6 vs 93.6 %) than PET-CT. Comparison of the areas under the ROC curves for the detection of metastatic lymph nodes demonstrated a non-significant difference (p = 0.055) between PET/CT and fused PET/MRI-DWI.

Conclusion

PET/MRI-DWI may be a valuable technique for N-staging patients with endometrial and cervical cancer, but more studies are needed to investigate its potential clinical utility.

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Titel: Comparison of retrospective PET and MRI-DWI (PET/MRI-DWI) image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases
verfasst von: Alessandro Stecco
Francesco Buemi
Alessia Cassarà
Roberta Matheoud
Gian Mauro Sacchetti
Alberto Arnulfo
Marco Brambilla
Alessandro Carriero
Publikationsdatum: 01.07.2016
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 7/2016
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-016-0626-5

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Comparison of retrospective PET and MRI-DWI (PET/MRI-DWI) image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases

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Objectives

Materials and methods

Results

Conclusion

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Objectives

Materials and methods

Results

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