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01.05.2019 | ABDOMINAL RADIOLOGY

Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment

verfasst von: Maria Ciolina, Damiano Caruso, Domenico De Santis, Marta Zerunian, Marco Rengo, Norma Alfieri, Daniela Musio, Francesca De Felice, Antonio Ciardi, Vincenzo Tombolini, Andrea Laghi

Erschienen in: La radiologia medica | Ausgabe 5/2019

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Abstract

Purpose

To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to tumor grading and to assess their reliability in predicting pathological complete response (pCR) before neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).

Materials and methods

Forty patients (24 male; mean age, 67.3 ± 8.1 years) with histologically proven LARC who had undergone 3-Tesla DCE-MRI before (MRI_1) and after CRT (MRI_2) between August 2015 and February 2016 were included in this retrospective study. DCE-MRI parameters at MRI_1 and MRI_2 were extracted by two board certified radiologists in consensus reading with Olea Sphere 2.3 software using the extended Tofts model. Based on DCE-MRI results, patients were divided in complete responders (CR) and non-complete responders (nCR) and the perfusion parameters were correlated to tumor grading and pCR.

Results

Wash-out and K_ep at MRI_1 showed significant correlation with LARC grading (P = 0.004 and 0.01, respectively). V_e showed a significant increase between MRI_1 (0.47 ± 0.27) and MRI_2 (0.63 ± 0.23; P = 0.007). K_trans measured at MRI_1 was significantly higher in CR (0.66 ± 0.48) compared to nCR (0.53 ± 0.34, P = 0.02).

Conclusion

Wash-out and K_ep measured before CRT correlate with LARC grading. V_e changes during CRT, while K_trans measured before CRT may predict the response to therapy. Therefore, DCE-MRI parameters can predict tumor aggressiveness and CRT efficacy, playing a role as imaging biomarkers in patients with LARC.

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Titel: Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment
verfasst von: Maria Ciolina
Damiano Caruso
Domenico De Santis
Marta Zerunian
Marco Rengo
Norma Alfieri
Daniela Musio
Francesca De Felice
Antonio Ciardi
Vincenzo Tombolini
Andrea Laghi
Publikationsdatum: 01.05.2019
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 5/2019
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-018-0978-0

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Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment

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