Erschienen in:
01.11.2014 | Original Article
Prognosis of patients with intermediate-stage hepatocellular carcinomas based on the Child-Pugh score: subclassifying the intermediate stage (Barcelona Clinic Liver Cancer stage B)
verfasst von:
Koichiro Yamakado, Shiro Miyayama, Shozo Hirota, Kimiyoshi Mizunuma, Kenji Nakamura, Yoshitaka Inaba, Satoshi Yamamoto, Kunihiro Matsuo, Norifumi Nishida, Takeshi Aramaki, Hiroshi Anai, Shinichi Kora, Shigeo Oikawa, Ken Watanabe, Taku Yasumoto, Kinya Furuichi, Masato Yamaguchi
Erschienen in:
Japanese Journal of Radiology
|
Ausgabe 11/2014
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Abstract
Purpose
Retrospective evaluation of intermediate-stage hepatocellular carcinoma (HCC) patient survival after undergoing chemoembolization based on the Child-Pugh score.
Materials and methods
Data of intermediate-stage HCC patients undergoing chemoembolization were gathered from 43 centers in Japan. Overall survival rates were compared with Child-Pugh scores.
Results
Of the 329 patients examined in this study, Child-Pugh scores were 5 (CP-5) in 136 patients (41.3 %), 6 (CP-6) in 101 patients (30.7 %), 7 (CP-7) in 58 (17.7 %), 8 (CP-8) in 22 (6.7 %), and 9 (CP-9) in 12 (3.6 %). Two-year survival rates were 77.5 % in CP-5 patients (p = 0.047 vs. CP-6), 65.1 % in CP-6 patients (p = 0.038 vs. CP-7), 51.3 % in CP-7 patients (p = 0.30 vs. CP-8, p = 0.034 vs. CP-9), 50.3 % in CP-8 patients (p = 0.0065 vs. CP-9), and 16.7 % in CP-9 patients. Two-year survival rates were 77.2 % in 139 patients meeting the 4 tumors of 7 cm criterion with Child-Pugh class A (B1) (p < 0.0001 vs. B2), 59.5 % in 178 patients other than B1 and B3 (B2) (p = 0.0014 vs. B3), and 16.7 % in 12 patients with Child-Pugh score 9 (B3).
Conclusion
The Child-Pugh score is a useful prognostic factor to stratify intermediate-stage HCC patients.