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Erschienen in: Japanese Journal of Radiology 12/2016

06.10.2016 | Review

Neuroimaging findings of Zika virus infection: a review article

verfasst von: Mohammad Zare Mehrjardi, Elham Keshavarz, Andrea Poretti, Adriano N. Hazin

Erschienen in: Japanese Journal of Radiology | Ausgabe 12/2016

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Abstract

Zika virus (ZIKV) is an arbovirus from the Flaviviridae family. It is usually transmitted by mosquito bite. There have been no reports of severe symptoms caused by ZIKV infection up until the last few years. In October 2013 an outbreak was reported in French Polynesia with severe neurological complications in some affected cases. In November 2015, the Ministry of Health of Brazil attributed the increased number of neonatal microcephaly cases in northeastern Brazil to congenital ZIKV infection. The rapid spread of the virus convinced the World Health Organization to announce ZIKV infection as a “Public Health Emergency of International Concern” in February 2016. The main neuroimaging findings in congenital ZIKV infection include microcephaly which is the hallmark of the disease, other malformations of cortical development (e.g., lissencephaly, heterotopia, etc.), parenchymal calcifications, unilateral or bilateral ventriculomegaly, enlarged extra-axial CSF spaces, dysgenesis of the corpus callosum, agenesis of the cavum septum pellucidum, cerebellar and brainstem hypoplasia, and ocular abnormalities. ZIKV infection may also cause Guillain-Barré syndrome and acute disseminated encephalomyelitis in adults. Familiarity with neuroimaging findings of congenital and acquired ZIKV infection is crucial to suspect this disease in residents of endemic regions and travelers to these areas.
Literatur
2.
Zurück zum Zitat Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika virus. N Engl J Med. 2016;374(16):1552–63.CrossRefPubMed Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika virus. N Engl J Med. 2016;374(16):1552–63.CrossRefPubMed
3.
Zurück zum Zitat Singh RK, Dhama K, Malik YS, Ramakrishnan MA, Karthik K, Tiwari R, Saurabh S, Sachan S, Joshi SK. Zika virus: emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives—a comprehensive review. Vet Q. 2016;36(3):150–75.CrossRefPubMed Singh RK, Dhama K, Malik YS, Ramakrishnan MA, Karthik K, Tiwari R, Saurabh S, Sachan S, Joshi SK. Zika virus: emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives—a comprehensive review. Vet Q. 2016;36(3):150–75.CrossRefPubMed
4.
Zurück zum Zitat Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21(2):359–61.CrossRefPubMedPubMedCentral Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21(2):359–61.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Shuaib W, Stanazai H, Abazid AG, Mattar AA. Re-emergence of zika virus: a review on pathogenesis, clinical manifestations, diagnosis, treatment, and prevention. Am J Med. 2016; 129(8):879.e7–879. Shuaib W, Stanazai H, Abazid AG, Mattar AA. Re-emergence of zika virus: a review on pathogenesis, clinical manifestations, diagnosis, treatment, and prevention. Am J Med. 2016; 129(8):879.e7–879.
6.
Zurück zum Zitat Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014;44(7):302–7.CrossRefPubMed Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014;44(7):302–7.CrossRefPubMed
7.
Zurück zum Zitat Anderson KB, Thomas SJ, Endy TP. The emergence of zika virus: a narrative review. Ann Intern Med. 2016;165(3):175–83.CrossRefPubMed Anderson KB, Thomas SJ, Endy TP. The emergence of zika virus: a narrative review. Ann Intern Med. 2016;165(3):175–83.CrossRefPubMed
8.
Zurück zum Zitat Chibueze EC, Tirado V, da Silva Lopes K, Balogun OO, Takemoto Y, Swa T, et al. Zika virus infection in pregnancy: a systematic review of disease course and complications. Bull World Health Organ. E-pub: 2016. Chibueze EC, Tirado V, da Silva Lopes K, Balogun OO, Takemoto Y, Swa T, et al. Zika virus infection in pregnancy: a systematic review of disease course and complications. Bull World Health Organ. E-pub: 2016.
9.
Zurück zum Zitat Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Brazilian Medical Genetics Society—Zika Embryopathy Task Force. Possible association between Zika virus infection and microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(3):59–62.CrossRefPubMed Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Brazilian Medical Genetics Society—Zika Embryopathy Task Force. Possible association between Zika virus infection and microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(3):59–62.CrossRefPubMed
10.
Zurück zum Zitat de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort R, Jr. Ocular findings in infants with microcephaly associated with presumed zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016. de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort R, Jr. Ocular findings in infants with microcephaly associated with presumed zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016.
11.
Zurück zum Zitat Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F. Zika virus infection complicated by Guillain-Barré syndrome — case report, French Polynesia, December 2013. Euro Surveill. 2014;19:20720.CrossRefPubMed Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F. Zika virus infection complicated by Guillain-Barré syndrome — case report, French Polynesia, December 2013. Euro Surveill. 2014;19:20720.CrossRefPubMed
12.
Zurück zum Zitat Simões E, Silva AC, Moreira JM, Romanelli RM, Teixeira AL. Zika virus challenges for neuropsychiatry. Neuropsychiatr Dis Treat. 2016;12:1747–60.CrossRef Simões E, Silva AC, Moreira JM, Romanelli RM, Teixeira AL. Zika virus challenges for neuropsychiatry. Neuropsychiatr Dis Treat. 2016;12:1747–60.CrossRef
13.
Zurück zum Zitat Faye O, Faye O, Diallo D, Diallo M, Weidmann M, Sall AA. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes. Virol J. 2013;22(10):311.CrossRef Faye O, Faye O, Diallo D, Diallo M, Weidmann M, Sall AA. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes. Virol J. 2013;22(10):311.CrossRef
14.
Zurück zum Zitat Update: interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure—United States, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65:122–127. Update: interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure—United States, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65:122–127.
15.
Zurück zum Zitat Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ. 2016;352:i657-i657. Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ. 2016;352:i657-i657.
16.
Zurück zum Zitat Tong A, Flemming K, McInnes E, Oliver S, Craig J. Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Med Res Methodol. 2012;12:181.CrossRefPubMedPubMedCentral Tong A, Flemming K, McInnes E, Oliver S, Craig J. Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Med Res Methodol. 2012;12:181.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet. 2016;387(10033):2125–32.CrossRefPubMedPubMedCentral Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet. 2016;387(10033):2125–32.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Oliveira Melo AS, Malinger G, Ximenes R, et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol. 2016;47:6–7.CrossRefPubMed Oliveira Melo AS, Malinger G, Ximenes R, et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol. 2016;47:6–7.CrossRefPubMed
19.
Zurück zum Zitat Brasil P, Pereira JP Jr, Raja Gabaglia C, et al. Zika virus infection in pregnant women in Rio de Janeiro—preliminary report. N Engl J Med. doi: 10.1056/NEJMoa1602412. Brasil P, Pereira JP Jr, Raja Gabaglia C, et al. Zika virus infection in pregnant women in Rio de Janeiro—preliminary report. N Engl J Med. doi: 10.​1056/​NEJMoa1602412.
20.
Zurück zum Zitat Guillemette-Artur P, Besnard M, Eyrolle-Guignot D, et al. Prenatal brain MRI of fetuses with Zika virus infection. Pediatr Radiol. 2016;46:1032.CrossRefPubMed Guillemette-Artur P, Besnard M, Eyrolle-Guignot D, et al. Prenatal brain MRI of fetuses with Zika virus infection. Pediatr Radiol. 2016;46:1032.CrossRefPubMed
21.
Zurück zum Zitat Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, Rosenberg A, et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med. 2016;374(22):2142–51.CrossRefPubMed Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, Rosenberg A, et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med. 2016;374(22):2142–51.CrossRefPubMed
22.
Zurück zum Zitat Franca GV, Schuler-Faccini L, Oliveira WK, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 live births with complete investigation. Lancet. 2016; Epub June 29. Franca GV, Schuler-Faccini L, Oliveira WK, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 live births with complete investigation. Lancet. 2016; Epub June 29.
23.
Zurück zum Zitat Tarrant A, Garel C, Germanaud D, et al. Microcephaly: a radiological review. Pediatr Radiol. 2009;39:772–80.CrossRefPubMed Tarrant A, Garel C, Germanaud D, et al. Microcephaly: a radiological review. Pediatr Radiol. 2009;39:772–80.CrossRefPubMed
24.
Zurück zum Zitat Hazin AN, Poretti A, Cruz DDCS, et al. Computed tomographic findings in microcephaly associated with Zika virus. N Engl J Med. 2016;374:2193–5.CrossRefPubMed Hazin AN, Poretti A, Cruz DDCS, et al. Computed tomographic findings in microcephaly associated with Zika virus. N Engl J Med. 2016;374:2193–5.CrossRefPubMed
25.
Zurück zum Zitat De Fatima Vasco Aragao M, van der Linden V, Brainer-Lima AM, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. The BMJ. 2016; 353:i1901. De Fatima Vasco Aragao M, van der Linden V, Brainer-Lima AM, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. The BMJ. 2016; 353:i1901.
26.
Zurück zum Zitat Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MD, Moron A, Lederman HM. Microcephaly and Zika virus: neonatal neuroradiological aspects. Childs Nerv Syst. 2016;32(6):1057–60.CrossRefPubMedPubMedCentral Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MD, Moron A, Lederman HM. Microcephaly and Zika virus: neonatal neuroradiological aspects. Childs Nerv Syst. 2016;32(6):1057–60.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Baptista T, Quaghebeur G, Alarcon A. Neuroimaging findings of babies with microcephaly and presumed congenital Zika virus infection. The BMJ. 2016;353:i2194.CrossRefPubMed Baptista T, Quaghebeur G, Alarcon A. Neuroimaging findings of babies with microcephaly and presumed congenital Zika virus infection. The BMJ. 2016;353:i2194.CrossRefPubMed
28.
Zurück zum Zitat Fontes CA, Dos Santos AA, Marchiori E. Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection. Neuroradiology. Published online April 11, 2016. Fontes CA, Dos Santos AA, Marchiori E. Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection. Neuroradiology. Published online April 11, 2016.
29.
Zurück zum Zitat Hynson JL, Kornberg AJ, Coleman LT, et al. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001;56(10):1308–12.CrossRefPubMed Hynson JL, Kornberg AJ, Coleman LT, et al. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001;56(10):1308–12.CrossRefPubMed
30.
Zurück zum Zitat Young NP, Weinshenker BG, Lucchinetti CF. Acute disseminated encephalomyelitis: current understanding and controversies. Semin Neurol. 2008;28(1):84–94.CrossRefPubMed Young NP, Weinshenker BG, Lucchinetti CF. Acute disseminated encephalomyelitis: current understanding and controversies. Semin Neurol. 2008;28(1):84–94.CrossRefPubMed
31.
Zurück zum Zitat Adibi JJ, Marques ET Jr, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet. 2016;387(10027):1587–90.CrossRefPubMed Adibi JJ, Marques ET Jr, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet. 2016;387(10027):1587–90.CrossRefPubMed
32.
Zurück zum Zitat Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, et al. Zika virus associated with microcephaly. N Engl J Med. 374:951–958. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, et al. Zika virus associated with microcephaly. N Engl J Med. 374:951–958.
33.
Zurück zum Zitat Garcez PP, Loiola EC, Madeiro da Costa R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016;352:816–8.CrossRefPubMed Garcez PP, Loiola EC, Madeiro da Costa R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016;352:816–8.CrossRefPubMed
34.
Zurück zum Zitat Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. 2016;18:587–90.CrossRefPubMed Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. 2016;18:587–90.CrossRefPubMed
35.
Zurück zum Zitat Qian X, Nguyen HN, Song MM, et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell. 2016;165:1238–54.CrossRefPubMed Qian X, Nguyen HN, Song MM, et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell. 2016;165:1238–54.CrossRefPubMed
36.
Zurück zum Zitat Kornienko VN, Pronin IN. Diagnostic neuroradiology. New York: Springer; 2009. Kornienko VN, Pronin IN. Diagnostic neuroradiology. New York: Springer; 2009.
Metadaten
Titel
Neuroimaging findings of Zika virus infection: a review article
verfasst von
Mohammad Zare Mehrjardi
Elham Keshavarz
Andrea Poretti
Adriano N. Hazin
Publikationsdatum
06.10.2016
Verlag
Springer Japan
Erschienen in
Japanese Journal of Radiology / Ausgabe 12/2016
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-016-0588-5

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