Impact of Centralizing Gastric Cancer Surgery on Treatment, Morbidity, and Mortality
verfasst von:
S. D. Nelen, L. Heuthorst, R. H. A. Verhoeven, F. Polat, Ph. M. Kruyt, K. Reijnders, F. T. J. Ferenschild, J. J. Bonenkamp, J. E. Rutter, J. H. W. de Wilt, E. J. Spillenaar Bilgen
Centralization of gastric cancer surgery is thought to improve outcome and has been imposed in the Netherlands since 2012. This study analyzes the effect of centralization in terms of treatment outcome and survival in the Eastern part of the Netherlands.
Methods
All gastric cancer patients without distant metastases who underwent a gastrectomy in six hospitals in the Eastern part of the Netherlands between 2008 and 2011 (pre-centralization) and 2013–2016 (post-centralization) were selected from the Netherlands Cancer Registry. Patient and tumor characteristics and treatment outcomes (duration of surgery, blood loss, resection margin, lymphadenectomy, chemotherapy, postoperative complications and hospital stay, and overall and disease-free survival) were analyzed and compared between pre- and post-centralization.
Results
One hundred forty-four patients were included pre-centralization and 106 patients post-centralization. Patient and tumor characteristics were almost similar in the two periods. After centralization, more patients were treated with perioperative chemotherapy (25 vs. 42% p < 0.01). The proportion of patients treated with an adequate lymphadenectomy (21 vs. 93% p < 0.01) and laparoscopic surgery (6 vs. 40% p < 0.01) increased significantly (p < 0.01). The amount of cardiac complications (16 vs. 7.5% p < 0.05) decreased; however, complications needing a re-intervention were comparable (42 vs. 40% p = 0.79). Median hospital stay decreased from 10 to 8 days (p < 0.01). A 30-day mortality did not differ significantly (4.2 vs. 1.9%). A 1-year overall (78 vs. 80% p = 0.17) and disease-free survival (73 vs. 74% p = 0.66) remained stable.
Discussion
Centralizing gastric cancer treatment in the Eastern part of the Netherlands resulted in improved lymph node harvesting and a successful introduction of laparoscopic gastrectomies. Centralization has not translated into improved mortality, and other variables may also have led to these improved outcomes. Further research using a nationwide population-based study will be needed to confirm these data.
Hinweise
S.D. Nelen and L. Heuthorst contributed equally
Abkürzungen
NCR
Netherlands Cancer Registration
UICC
Union for International Cancer Control
TNM
Tumor, node, metastasis
CI
Confidence interval
HR
Hazard ratio
OS
Overall survival
Introduction
Centralization of gastric cancer treatment is believed to improve outcome. Performing more gastrectomies per year in one center should lead to better surgical training and more specialized oncological (perioperative) care. A study from Denmark has shown improved outcomes of gastric cancer after centralization of gastric cancer surgery, including less anastomotic leakages, a decreased 30-day mortality, and an improved lymph node harvesting.1 In the Netherlands, centralization of gastric cancer surgery has been imposed in 2012 by mandating a minimum of ten gastrectomies per hospital per year and as of 2013, to a minimum of 20 per year. In the Netherlands, the benefit of centralization of gastric cancer treatment has not yet been proven.
Previous Dutch studies that were conducted have researched the influence of surgical training and hospital volume on survival in gastric cancer.2,3 Data from the West of the Netherlands have already showed in 2009 that after standardization and surgical training, relative 5-year survival rates increased for resected gastric cancer patients (41 vs. 52% p = 0.06).2 Other data from the Netherlands Cancer Registry (NCR) showed that high hospital volume was associated with a higher amount of harvested lymph nodes during surgery and pathology, but a difference in survival after gastrectomy was not demonstrated. This was probably caused by the limited amount of gastric cancer patients that were treated before 2009 in high volume hospitals (i.e., ≥ 20 patients per year).3
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The aim of the present study was to examine the effects of centralization in terms of morbidity and mortality by comparing a cohort of surgical gastric cancer patients before (2008–2011) and after (2013–2016) centralization in the Eastern part of the Netherlands.
Methods
Primary data were obtained from the population-based Netherlands Cancer Registry (NCR). This registry serves the total Dutch population of almost 17 million inhabitants. The NCR is based on notification of all newly diagnosed malignancies in the Netherlands by the national automated pathological archive (PALGA). Additional sources are the national registry of hospital discharge and radiotherapy institutions. Specially trained data managers of the NCR routinely extract information on diagnosis, staging, and treatment from the medical records. The information on vital status is obtained by an annual linkage with the Municipal Administrative Databases, which register all deceased and emigrated persons in the Netherlands. Tumor staging was performed according to the 6th and 7th UICC TNM classification. In order to reduce the influence of differences between the different TNM versions, the 7th UICC TNM classification was recoded into the 6th UICC TNM classification. Due to the fact that the 7th version of the UICC TNM classification is more specific than the 6th version, it was impossible to recode the 6th version into the 7th version of the UICC TNM classification. Tumor site within the stomach was coded based on the International Classification of Diseases for Oncology: proximal/middle (cardia, fundus, corpus, and lesser and greater curvature (C16.0, C16.1, C16.2, C16.5, C16.6)), pyloric and antrum (C16.3, C16.4), and overlapping or not otherwise specified (C16.8, C16.9).4 Tumor histology was coded according the Lauren classification.5
Additional data on comorbidity and complications were retrospectively registered by a data manager. Patient history, comorbidities, and American Society of Anesthesiologists (ASA)-classification were extracted from the preoperative anesthesiology report. Seven different comorbidities were registered: diabetes mellitus, immune compromising diseases, pulmonary disease, kidney failure, liver failure, cardiovascular disease, and/or gastrointestinal disease. Time between diagnosis and treatment was defined as the time between the diagnostic biopsy result and the first treatment (neoadjuvant chemotherapy or surgery).
The occurrence of postoperative complications and reinterventions were extracted from medical records. Complications were defined as any unwanted effect of primary treatment leading to reintervention within 30 days after surgery. Postoperative complications consist of anastomotic leakage, intra-abdominal abscess, wound infection, postoperative bleeding, pneumonia, urinary tract infection, and cardiac complications and were ranked according to the Clavien-Dindo classification.6 Postoperative reinterventions were defined as surgical-, radiological, endoscopic measures or antibiotic therapy within 30 days after surgery. Tumor recurrence was registered when patients had histologically proven recurrent gastric cancer or a strong suggestion on computed tomography and/or gastroscopy.
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Before 2012, gastric cancer surgery in the Eastern part of the Netherlands was performed in six hospitals by 16 gastrointestinal surgeons of which only one surgeon performed laparoscopic surgery. After 2012, the gastric cancer surgery was centralized into one hospital (Rijnstate hospital) and was done by two teams with two gastrointestinal surgeons each. These four surgeons all performed laparoscopic gastrectomy. 2012 was a transitional year in which centralization was partly adopted and was therefore excluded from further analysis. For this study, we selected all patients with gastric cancer without distant metastases operated in the Eastern part of the Netherlands between January 2008 and December 2011 (pre-centralization) and patients who underwent gastrectomy in the Rijnstate hospital between January 2013 and June 2016 (post-centralization). In both pre- and post-centralization period, surgeons were well trained in laparoscopic surgery, and in the entire study period all patients were discussed in a multidisciplinary team meeting.
Statistical Analysis
Descriptive statistics were used to characterize the patients before and after centralization; significance was calculated by means of chi-square or Mann-Whitney test. Treatment modalities and outcome of treatment in terms of postoperative complications and hospital stay were compared by chi-square or Mann-Whitney test.
Survival time was defined as time from surgery to death or until January 1, 2016 for patients who were still alive. With exception for patients who underwent surgery in 2016, for these patients, survival time was defined as time from surgery to death or until the last hospital visit registered in the medical file in December 2016. Disease-free survival was defined as time from surgery to tumor recurrence (regardless of the location of recurrence) or until the last hospital visit registered in the medical file in December 2016 in which there was no evidence on tumor recurrence. Kaplan-Meier curves were generated to examine the overall- and disease-free survival and compared by log-rank test. Multivariable Cox regression analyses were performed to investigate the prognostic impact of centralization on overall survival after adjustment for patient and tumor characteristics. To prevent over fitting due to limited amount of events in our study population, multivariable analysis was limited to five variables. Results from survival analyses using Cox regression analyses were reported as hazard ratios (HR) and 95% confidence interval (CI). Reported p values of < 0.050 were considered statistically significant. All analyses were conducted using IBM SPSS Statistics Version 23 (International Business Machines Statistical Package for the Social Sciences).
Results
A total of 250 gastric cancer patients without distant metastasis who underwent gastric surgery were included. Before centralization, 144 patients (median follow-up time 43 months) were treated and 106 patients were treated post-centralization (median follow-up time 15 months, p < 0.01). Apart from variation in ASA-classification (p < 0.01), all other patient and tumor characteristics were comparable between both study populations (Table 1).
Table 1
Patient and tumor characteristics according to centralization status: pre-centralization 2008–2011 and post-centralization 2013–2016
Pre-centralization (N = 144)
Percent
Post-centralization (N = 106)
Percent
Significance
Follow-up (months)
Median 43 IQR 48 (15–63)
Median 15 IQR 17 (7–24)
< 0.01*
Age in years
< 70
65
45
47
44
0.90a
≥ 70
79
55
59
56
Gender
Male
90
63
60
57
0.35a
Female
54
38
46
43
BMI
Mean 25.1 (SD 4.0)
Mean 25.4 (SD 4.0)
0.27*
ASA-classification
I
17
12
7
6.6
<0.02a
II
81
56
74
70
III
35
24
21
20
IV
2
1.4
4
3.8
Unknown
9
6.3
0
0
Comorbidity
0
44
31
31
29
0.79a
1
63
44
45
43
≥ 2
36
25
30
28
Unknown
1
0.7
0
0
Previous abdominal surgery
Yes
54
38
33
31
0.38a
No
89
62
73
69
Unknown
1
0.7
0
0
Yes
12
8.3
6
5.7
0.49a
No
131
91
100
94
Unknown
1
0.7
0
0
Previous malignancy
Yes
20
14
20
19
0.40a
No
123
85
86
81
Unknown
1
0.7
0
0
pT-stage
0/×
10
6.9
9
9
0.36a
1
29
20
23
22
2A
17
12
20
19
2B
55
38
38
36
3
27
19
15
14
4
6
4.2
1
0.9
pN-stage
Nx
9
6.3
2
1.9
0.11a
0
78
54
51
48
1
43
30
34
32
2
13
9
15
14
3
1
0.7
4
3.8
Tumor topography
Proximal/middle
43
30
33
31
0.30a
Pyloric/antrum
62
43
53
50
Overlapping/not specified
39
27
20
19
Tumor grade
Well differentiated
8
5.6
4
3.8
0.12a
Moderately differentiated
16
11
22
21
Poorly/undifferentiated
68
47
39
37
Unknown
52
36
41
39
Type (Lauren classification)
Intestinal type
92
64
52
49
0.05a
Diffuse type
45
31
49
46
Indeterminate type
7
4.9
5
4.7
*Mann-Whitney test
aPearson chi square
Treatment
Centralization did not significantly affect time between diagnosis and start of treatment (Table 2). The amount of partial gastrectomies increased non-significantly, 68% between 2008 and 2011 and 74% between 2013 and 2016 (p = 0.34), and there was no significant increase in the number of microscopically radical resections (R0), 79% before centralization, and 87% after centralization (p = 0.16) (Table 2).
Table 2
Surgery and hospital stay according to centralization status: pre-centralization 2008–2011 and post-centralization 2013–2016
Pre-centralization N = 144
Post-centralization N = 106
Percent
Percent
Significance
Time between diagnosis and treatment (days)
Median 35.50 IQR 23 (27–50)
Median 34.00 IQR 17 (28–45)
0.94*
Type of chemotherapy
None
68
47
47
44
0.65a
Only neoadjuvant
37
26
14
13
0.02a
Only adjuvant
3
2.1
1
0.9
0.44a
Peri-operative
36
25
44
42
<0.01a
Type of resection
Partial gastrectomy
98
68
78
74
0.34a
Total gastrectomy
46
32
28
26
Resection method
Laparotomy
133
92
62
59
<0.01a
Laparoscopic
8
5.6
42
40
Unknown
3
2.1
2
1.9
Duration surgery (minutes)
Median 147 IQR 69 (116–185)
Median 180 IQR 74 (154–228)
<0.01*
Blood loss (ml)
Median 300 IQR 488 (200–688)
Median 200 IQR 313 (100–413)
<0.01*
Lymphnodes harvested
< 15
114
79
8
8
<0.01a
≥ 15
30
21
98
93
Tumor residue
R0
115
79
92
87
0.16a
R1
22
15
13
12
Unknown
7
4.9
1
0.9
Hospital stay (days)
Median 10 IQR 7 (7–14)
Median 8 IQR 4 (7–11)
<0.01*
*Mann-Whitney test
aPearson chi square
After centralization, there was a significant increase in the use of perioperative chemotherapy (25 vs. 42%, p < 0.01); patients receiving no chemotherapy remained almost equal (47 vs. 44% p = 0.65), and the amount of patients receiving only neo-adjuvant treatment decreased significantly (26 vs. 13% p = 0.02). More patients were treated laparoscopically; respectively, 5.6 and 40% of all patients received a laparoscopic gastrectomy before and after centralization (p < 0.01). Median duration of surgery increased (147 vs. 180 min (p < 0.01), and the median amount of peroperative blood loss decreased (300 vs. 200 ml (p < 0.01). There was a significant increase of patients who had an adequate amount of more than 15 lymph nodes harvested during surgery from 21 towards 93% after centralization (p < 0.01). The median hospital stay decreased with 2 days after centralization (10 vs. 8 days p < 0.01) (Table 2.)
Complications
No significant difference was seen in the amount and grade of postoperative complications (Table 3). The amount of anastomotic leakages did not decrease significantly, 9.0% between 2008 and 2011 and 6.6% between 2012 and 2016 (p = 0.49). The occurrence of an intra-abdominal abscess did not decrease after centralization (2.8 vs. 6.6% p = 0.15). However, the amount of patients with cardiac complications (16 vs. 7.5% p < 0.05) decreased significantly after centralization (Table 4).
Table 3
Postoperative complications according the Clavien-Dindo classification of surgical complications
Pre-centralization (N = 144)
Post-centralization (N = 106)
p value
Number
Percent
Number
Percent
< II
84
58
65
61
0.51
II
32
22
23
22
III
10
7
11
10
IV
11
8
5
5
V
7
5
2
2
Table 4
Postoperative complications in 30 days after surgery according to centralization status: pre-centralization 2008–2011 and post-centralization 2013–2016
Pre-centralization (N = 144)
Post-centralization (N = 106)
p value
Number
Percent
Number
Percent
Postoperative complications
60
42
42
40
0.75
Anastomotic leakage
13
9.0
7
6.6
0.49
Intra-abdominal abscess
4
2.8
7
6.6
0.15
Wound infection
5
3.5
2
1.9
0.45
Postoperative bleeding
6
4.2
3
2.8
0.58
Pneumonia
29
20
19
18
0.66
Urinary tract infection
5
3.5
0
0
0.05
Cardiac complications
23
16
8
7.5
< 0.05
Additional analysis on the influence of type of surgery (i.e., laparoscopy vs. laparotomy) showed no significant difference in the amount of postoperative morbidity (39 vs. 42% p = 0.76).
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There were no statistically significant differences in the amount of re-interventions between both study populations (Table 5). In both study periods, 12% of all patients underwent a postoperative surgical re-intervention. This was mainly caused by (a suspicion of) a failure of the gastrojejunostomy (pre-centralization 6.9% and post-centralization 6.6%). A 30-day mortality was 4.2 and 1.9%, respectively, (p = 0.17) before and after centralization. No statistically significant difference was seen in the 30-day mortality for both types of surgery (i.e., laparoscopy vs. laparotomy (2.0 vs. 3.6% p = 0.56).
Table 5
Postoperative re-interventions in 30 days after surgery according to centralization status: pre-centralization 2008–2011 and post-centralization 2013–2016
Pre-centralization (N = 144)
Post-centralization (N = 106)
p value
Number
Percent
Number
Percent
Surgical intervention
17
12
13
12
0.91
Radiological intervention
11
7.6
3
2.8
0.10
Endoscopic intervention
2
1.4
3
2.8
0.42
Antibiotic therapy
48
33
36
34
0.92
Recurrence and Survival
There were no statistically significant differences in disease-free and overall survival between patients treated before and after centralization in univariable and multivariable analysis. Kaplan-Meier survival analyses showed that a 1-year disease-free survival was 73% before and 74% after centralization (Fig. 1, p = 0.66). A 1-year overall survival of all patients treated before centralization was 78% and after centralization 80%; A 2-year overall survival was 62 versus 70% (Fig. 2, p = 0.17). Additional Kaplan-Meier survival analysis to examine the 2-year overall survival for both types of surgery (i.e., laparoscopy vs. laparotomy), showed no significant difference (Figure not shown, p = 0.35). Multivariable cox regression analysis showed no significant effect of centralization on overall survival (Table 6, HR = 0.6 95% C.I. 0.4–1.1 p = 0.08). However, an impact was seen of tumor stage on overall survival (Table 6, HR = 9.6 95% C.I. 4.6–19.7 p < 0.01).
Fig. 1
Kaplan-Meier 2-year disease-free survival curve. Patients grouped by centralization status. p = 0.66 (Log Rank test)
Fig. 2
Kaplan-Meier 2-year overall survival curve. Patients grouped by centralization status. p = 0.17 (Log Rank test)
Table 6
Cox regression analyses. The influence of different clinicopathological factors on survival
This is the first study showing improved treatment outcome after centralization of gastric cancer treatment in the Netherlands since centralization had been effectuated in 2012. Gastric cancer patients significantly more often received perioperative chemotherapy and laparoscopic gastrectomy; the amount of perioperative blood loss significantly decreased and more patients received an adequate lymphadenectomy. After surgery, patients remained hospitalized for a significantly shorter period of time. Also after centralization, patients had significantly less postoperative cardiac complications, which might be caused by improved preoperative optimalization and perioperative monitoring.3,7 On the other hand, 30-day mortality, disease-free and overall survival did not improve significantly after centralization of gastric cancer treatment in the Eastern part of the Netherlands.
The introduction of laparoscopic gastrectomy in this region of the Netherlands, makes this study more difficult to interpret. It is suggested that laparoscopic gastrectomy causes less perioperative blood loss, fewer postoperative complications, shorter hospital stay, but equal surgical oncological results (i.e., tumor residue, lymph nodes harvest), and postoperative mortality.8–10 The abovementioned improved results of gastric cancer treatment after centralization could thus also be due to the introduction of laparoscopic surgery. However, introduction and performance of laparoscopic gastrectomy requires a certain number of resection per surgeon per time period. Therefore, it is safer and easier to perform laparoscopic gastric surgery in one high volume hospital than in six low volume centers. Various studies suggest that the learning curve of a laparoscopic gastrectomy is considered complete after more than 50 gastrectomies.11,12 This study showed that in our region, less than 40 gastrectomies are being performed per year. Dividing these cases over several hospitals, would have extended the surgeons learning curve for laparoscopic gastrectomy over several years.
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The importance of centralizing low frequent and complex cancer care into high volume hospitals is endorsed globally1,3,13–15. Nevertheless, for gastric cancer, the benefit of centralizing treatment has not been proven beyond doubt; studies on centralization of gastric cancer care are often heterogeneous and occasionally conflicting.16–19 In recent years, several studies on centralization of gastric cancer care in the UK have been published.17–19 In those studies, both esophagus and gastric cancer are combined despite well-known differences in treatment, survival, and impact of centralization.20 Chan et al. reported decreased morbidity, mortality, and length of hospital stay after centralization.17 Next to that, the rate of patients treated with curative intent increased from 21 to 36%. However, another UK study in which survival was shown separately for gastric and esophagus cancer, showed no significant improvement of median survival after centralization for gastric cancer.18 Recently, a study by Mamidanna et al. demonstrated that mortality after gastrectomy was lower for surgeons with higher volumes.15 This study, done in over 12,000 patients showed that for each additional gastrectomy per year, 30-day mortality decreased significantly.15
After centralization of gastric cancer in the Eastern part of the Netherlands, there was a decrease in the incidence of surgically treated gastric cancer patients (N = 144 patients vs. N = 106 patients). Apart from the difference in the length of both study periods, this could be caused by the decreasing incidence of curative treatable gastric cancer.21 Furthermore, it could be possible that centralized hospitals perform a more critical preoperative selection, causing more patients to be excluded from surgical intervention.
Also an increased use of perioperative chemotherapy was shown in this study. One possible explanation for the increased use perioperative chemotherapy could be that centralization has led to stricter compliance of the Dutch guidelines for gastric cancer treatment which is introduced in May 2009. This guideline recommends perioperative chemotherapy with an epirubicin, cisplatin and/or fluorouracil based regime in patients with stage II and III gastric cancer. The guidelines were recently further expanded but recommendations considering perioperative chemotherapy remained similar.22 Besides that, the increased hospital volume after centralization has probably led to more experience in treating (high-risk) patients with perioperative chemotherapy and thereby better awareness of the possibilities, risks, and benefits of perioperative chemotherapy.
In this study, the increased use of perioperative chemotherapy was mainly due to increased use of adjuvant chemotherapy. A possible explanation for this is that patients in the post-centralization group had a shorter and/or better recovery after surgery (i.e., decreased hospital stay, less blood loss, and less postoperative complications). Postoperative complications are one of the main reasons for not starting postoperative chemotherapy.16 Completion of perioperative chemotherapy is able to improve 5-year overall and disease-free survival with more than 10%.23,24 However, in this retrospective study, the increased use of perioperative chemotherapy post-centralization did not result into an increased survival benefit. This is in line with the suggestion that adjuvant chemotherapy offers limited additional survival benefit for patients with curatively resected gastric cancer25,26.
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The increased amount of harvested lymph nodes might be the effect of more experienced and trained surgeons in performing an adequate lymphadenectomy, but also due to the diligence and effort put in these time-consuming examinations by pathology departments.27 An adequate lymphadenectomy is especially relevant in order to predict prognosis, by assessing an adequate and reliable UICC TNM N-stage.28 But evidence also suggests that resection of 15 or more lymph nodes resulted in an improvement of 10-year disease-specific survival with more than 15%.29–31 In the present study, a survival benefit due to the improved lymphadenectomy could not be demonstrated. This might be caused due to the suggestion that surgical lymphadenectomy before and after centralization remained equal, but harvesting of lymph nodes by pathology department improved after centralization. Variation in evaluated lymph nodes between pathology departments has been studied before in the Netherlands.27 Lemmens et al. investigated the median-evaluated lymph nodes in six different pathology departments between 1999 and 2007 and showed a variation between 5 and 9 median evaluated nodes.27 Another explanation for the lack of survival benefit after centralization might be the low number of patients.
This study showed no significant improvement in the 30-day mortality and the 1-year overall survival. Before centralization, 30-day mortality (4.2%) was already lower than the nationwide average of 6.9%.32 Mortality rates after gastric surgery in the Eastern part of the Netherlands were also among the lowest compared to various European countries, ranging from 3.5 to 6.9%32 and only slightly higher than in the Danish study after their national centralization (2.4%).1 This relatively good outcome would be difficult to improve significantly after centralization. Moreover, producing a statistically significant difference in overall survival before and after centralization will probably require a larger study population and a longer follow-up. Possibly with a lager study population, the 40% risk reduction in multivariate analysis of the current study could result in statistical significance. Nevertheless, a postoperative mortality after centralization of 1.8% is a very satisfying outcome.
To conclude, this is the first retrospective cohort study to show a positive effect of centralizing gastric cancer treatment in the Netherlands. More perioperative chemotherapy, more harvested lymph nodes during surgery and/or pathology, less peroperative blood loss, and less postoperative cardiac complications, have however not yet led to a significant improvement of overall or disease-free survival. This is probably due to the small study population. A nationwide population based study will be needed to show a significant improvement in overall survival.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
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Impact of Centralizing Gastric Cancer Surgery on Treatment, Morbidity, and Mortality
verfasst von
S. D. Nelen L. Heuthorst R. H. A. Verhoeven F. Polat Ph. M. Kruyt K. Reijnders F. T. J. Ferenschild J. J. Bonenkamp J. E. Rutter J. H. W. de Wilt E. J. Spillenaar Bilgen
Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
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