Erschienen in:
01.11.2015 | Original Research
Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans
verfasst von:
Corrine I. Voils, PhD, Cynthia J. Coffman, PhD, Janet M. Grubber, MSPH, David Edelman, MD, MHS, Azita Sadeghpour, Ph.D., MS, Matthew L. Maciejewski, PhD, Jamiyla Bolton, MS, Alex Cho, MD, MBA, Geoffrey S. Ginsburg, MD, PhD, William S. Yancy Jr., MD, MHS
Erschienen in:
Journal of General Internal Medicine
|
Ausgabe 11/2015
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Abstract
Objective
We examined the clinical utility of supplementing type 2 diabetes mellitus (DM) risk counseling with DM genetic test results and counseling.
Research Design and Methods
In this randomized controlled trial, non-diabetic overweight/obese veteran outpatients aged 21 to 65 years received DM risk estimates for lifetime risk, family history, and fasting plasma glucose, followed by either genetic test results (CR+G; N = 303) or control eye disease counseling (CR+EYE; N = 298). All participants received brief lifestyle counseling encouraging weight loss to reduce the risk of DM.
Results
The mean age was 54 years, 53% of participants were black, and 80% were men. There was no difference between arms in weight (estimated mean difference between CR+G vs. CR+EYE at 3 months = 0.2 kg, 95% CI: −0.3 to 0.7; at 6 months = 0.4 kg, 95 % CI: −0.3 to 1.1), insulin resistance, perceived risk, or physical activity at 3 or 6 months. Calorie and fat intake were lower in the CR+G arm at 3 months (p’s ≤ 0.05) but not at 6 months (p’s > 0.20).
Conclusions
Providing patients with genetic test results was not more effective in changing patient behavior to reduce the risk of DM compared to conventional risk counseling.