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Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography

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Abstract

The middle longitudinal fascicle (MdLF) is a major fiber connection running principally between the superior temporal gyrus and the parietal lobe, neocortical regions of great biological and clinical interest. Although one of the most prominent cerebral association fiber tracts, it has only recently been discovered in humans. In this high angular resolution diffusion imaging (HARDI) MRI study, we delineated the two major fiber connections of the human MdLF, by examining morphology, topography, cortical connections, biophysical measures, volume and length in seventy-four brains. These two fiber connections course together through the dorsal temporal pole and the superior temporal gyrus maintaining a characteristic topographic relationship in the mediolateral and ventrodorsal dimensions. As these pathways course towards the parietal lobe, they split to form separate fiber pathways, one following a ventrolateral trajectory and connecting with the angular gyrus and the other following a dorsomedial route and connecting with the superior parietal lobule. Based on the functions of their cortical affiliations, we suggest that the superior temporal-angular connection of the MdLF, i.e., STG(MdLF)AG plays a role in language and attention, whereas the superior temporal-superior parietal connection of the MdLF, i.e., STG(MdLF)SPL is involved in visuospatial and integrative audiovisual functions. Furthermore, the MdLF may have clinical implications in neurodegenerative disorders such as primary progressive aphasia, frontotemporal dementia, posterior cortical atrophy, corticobulbar degeneration and Alzheimer’s disease as well as attention-deficit/hyperactivity disorder and schizophrenia.

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Acknowledgments

This study was supported, in part, by grants from: NIDA 1R01DA027804-01 (NM), NINDS R21NS077059 (NM and BCD); the National Institute of Health (K05 MH070047 and R01 MH 50740 (MES), P50MH 080272-CIDAR award (MES and MK), R01 M074794 (MK), the Department of Veterans Affairs Merit Award (MES), the VA Schizophrenia Center Grant (MES); the National Alliance for Medical Image Computing (NA-MIC), the latter a grant supported through the National Institutes of Health Roadmap for Medical Research, Grant U54 EB005149 (MK, MES); Progetto Roberto Rocca Foundation (MGP). The authors would like to thank Dr. Lichen Liang for his contribution to this manuscript.

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Authors and Affiliations

  1. Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA, 02129, USA

    N. Makris, G. M. Papadimitriou, C. Yergatian & B. C. Dickerson

  2. Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    N. Makris, D. Wassermann, Y. Rathi, C. Yergatian, M. E. Shenton & M. Kubicki

  3. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02215, USA

    N. Makris

  4. Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milano, Italy

    M. G. Preti

  5. Magnetic Resonance Laboratory, Fondazione Don Gnocchi, Milano, Italy

    M. G. Preti

  6. From the Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA

    M. E. Shenton

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  1. N. Makris
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  2. M. G. Preti
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  7. B. C. Dickerson
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  8. M. E. Shenton
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  9. M. Kubicki
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Correspondence to N. Makris.

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M. G. Preti and D. Wassermann contributed equally to this study.

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Makris, N., Preti, M.G., Wassermann, D. et al. Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography. Brain Imaging and Behavior 7, 335–352 (2013). https://doi.org/10.1007/s11682-013-9235-2

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