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The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer

  • SI: Neuroimaging Studies of Cancer and Cancer Treatment
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Abstract

To examine relationships following adjuvant chemotherapy between circulating pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints in early stage breast cancer patients. 33 breast cancer patients who had completed initial treatment (surgery, ± radiation, 23 chemotherapy, 10 no chemotherapy) obtained resting (18)F-FDG PET/CT brain imaging at baseline and 1 year later. Pro-inflammatory cytokine markers (IL-1ra, sTNF-RII, CRP, and IL-6) and cognitive complaints were also assessed at both time points. At baseline, consistent correlations were seen between the left medial frontal and right inferior lateral anterior temporal cortices and inflammatory markers within the chemotherapy group, and not in the no chemotherapy group. After 1 year, correlations persisted in the medial frontal cortex and the temporal cortex, the latter shifting superiorly. Both of these regional correlations demonstrated the highest levels of significance when looking across the 1 year time frame (IL-1ra: peak voxel p < 0.0005; cluster size p < 0.0005, p = 0.001 after correction (medial prefrontal), p < 0.0005; cluster size p = 0.001, p = 0.029 corr. (anterior temporal), sTNF-RII: p < 0.0005; cluster size p = 0.001, p = 0.040 corr. (medial prefrontal)). Positive correlations were also seen within the chemotherapy group between baseline memory complaints and the medial frontal (p < 0.0005; cluster size p < 0.0005, p < 0.0005 corr.) and anterior temporal (p < 0.0005; cluster size p < 0.0005, p = 0.002 corr.) cortices at baseline and 1 year later. Metabolism in the medial prefrontal cortex and anterior temporal cortex was found to correlate with both memory complaints and cytokine marker levels in chemotherapy patients.

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Acknowledgments

Supported by grant NIH/NCI R01 CA 109650 and the Breast Cancer Research Foundation (PAG); R01-AG034588; R01-AG026364; R01 CA160245-01; R01-CA119159; R01 HL095799; R01 DA032922-01; P30-AG028748 to MRI; and UCLA CTSI UL1TR000124, the Cousins Center for Psychoneuroimmunology (MRI).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 200 Medical Plaza, Suite B114, Mail Code: 737024, Los Angeles, CA, 90095-7370, USA

    K. L. Pomykala, S. Mallam, I. Cheng, R. Ahn & D. H. S. Silverman

  2. Department of Health Policy & Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA

    P. A. Ganz

  3. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    P. A. Ganz

  4. Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, USA

    P. A. Ganz, J. E. Bower & L. Kwan

  5. Department of Psychology, University of California, Los Angeles, CA, USA

    J. E. Bower & M. R. Irwin

  6. Cousins Center of Psychoneuroimmunology, Semel Institute for Neuroscience, Los Angeles, CA, USA

    J. E. Bower, E. C. Breen & M. R. Irwin

  7. VA Greater Los Angeles Health Care System, Los Angeles, CA, USA

    S. A. Castellon

  8. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    S. A. Castellon, E. C. Breen & M. R. Irwin

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  1. K. L. Pomykala
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  11. D. H. S. Silverman
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Correspondence to D. H. S. Silverman.

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Pomykala, K.L., Ganz, P.A., Bower, J.E. et al. The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer. Brain Imaging and Behavior 7, 511–523 (2013). https://doi.org/10.1007/s11682-013-9243-2

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