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Obesity Surgery
Erschienen in: Obesity Surgery 2/2009

01.02.2009 | Review

Do Incretins Play a Role in the Remission of Type 2 Diabetes after Gastric Bypass Surgery: What are the Evidence?

verfasst von: Mousumi Bose, Blanca Oliván, Julio Teixeira, F. Xavier Pi-Sunyer, Blandine Laferrère

Erschienen in: Obesity Surgery | Ausgabe 2/2009

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Abstract

Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 diabetes (T2DM). The mechanisms by which this remission occurs are unclear. Besides weight loss and caloric restriction, the changes in gut hormones that occur after GBP are increasingly gaining recognition as key players in glucose control. Incretins are gut peptides that stimulate insulin secretion postprandially; the levels of these hormones, particularly glucagon-like peptide-1, increase after GBP in response to nutrient stimulation. Whether these changes are causal to changes in glucose homeostasis remain to be determined. The purpose of this review is to assess the evidence on incretin changes and T2DM remission after GBP, and the possible mechanisms by which these changes occur. Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated.
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Metadaten
Titel
Do Incretins Play a Role in the Remission of Type 2 Diabetes after Gastric Bypass Surgery: What are the Evidence?
verfasst von
Mousumi Bose
Blanca Oliván
Julio Teixeira
F. Xavier Pi-Sunyer
Blandine Laferrère
Publikationsdatum
01.02.2009
Verlag
Springer New York
Erschienen in
Obesity Surgery / Ausgabe 2/2009
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9696-3

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