Skip to main content
Erschienen in: Obesity Surgery 9/2010

01.09.2010 | Clinical Research

Association of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women

verfasst von: Montserrat Broch, José Manuel Gómez, Ma Teresa Auguet, Nuria Vilarrasa, Rosa Pastor, Iñaki Elio, Montserrat Olona, Antonio García-España, Cristóbal Richart

Erschienen in: Obesity Surgery | Ausgabe 9/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

Although the adipokine retinol-binding protein-4 (RBP4) has been implicated in the development of obesity-related insulin resistance, its role in human obesity is still unclear. Our objectives were to find out the effect on RBP4 systemic levels of a weight loss induced by gastric bypass surgery and to analyze RBP4 relationships with insulin resistance, parameters of body composition, lipid metabolism, and inflammation.

Methods

Sixty-three obese women were analyzed before and 12 months after surgery of systemic concentrations of RBP4, fasting glucose, insulin, lipid profile molecules, and inflammation-related proteins (C-reactive protein, tumor necrosis factor-alpha receptors 1 and 2, interleukin-18, and adiponectin), and waist and hip circumference measurements, body mass index calculation, and insulin resistance index by homeostasis model assessment were also made.

Results

We found that RBP4 levels were lower after weight reduction by gastric bypass surgery (p < 0.0001). We found RBP4 associated with triglycerides before (β = 0.37, p = 0.02) and after surgery (β = 0.59, p < 0.0001) and negatively with weight loss after surgery (β = −0.37, p = 0.003). When expressed as a percentage of change, the decrease of RBP4 was related to the reduction in the levels of triglycerides and with the increase in HDL-cholesterol (β = 0.73, p = 0.02 and β = 0.62, p = 0.04, respectively). Others parameters analyzed, including inflammatory markers, were not related to RBP4.

Conclusions

This study shows that, in obese women and after a substantial weight loss due to bariatric surgery, RBP4 was related to weight status and lipid parameters rather than to insulin sensitivity or inflammatory markers.
Literatur
1.
Zurück zum Zitat Jensen MD. Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008;93:S57–63.CrossRefPubMed Jensen MD. Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008;93:S57–63.CrossRefPubMed
2.
Zurück zum Zitat Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008;93:S64–73.CrossRefPubMed Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008;93:S64–73.CrossRefPubMed
3.
Zurück zum Zitat Kloting N, Graham TE, Berndt J, et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metabolism. 2007;6:79–87.CrossRefPubMed Kloting N, Graham TE, Berndt J, et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metabolism. 2007;6:79–87.CrossRefPubMed
4.
Zurück zum Zitat Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–62.CrossRefPubMed Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–62.CrossRefPubMed
5.
Zurück zum Zitat Takashima N, Tomoike H, Iwai N. Retinol-binding protein 4 and insulin resistance. N Engl J Med. 2006;355:1392–5.CrossRefPubMed Takashima N, Tomoike H, Iwai N. Retinol-binding protein 4 and insulin resistance. N Engl J Med. 2006;355:1392–5.CrossRefPubMed
6.
Zurück zum Zitat Stefan N, Hennige AM, Staiger H, et al. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care. 2007;30:1173–8.CrossRefPubMed Stefan N, Hennige AM, Staiger H, et al. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care. 2007;30:1173–8.CrossRefPubMed
7.
Zurück zum Zitat Broch M, Vendrell J, Ricart W, et al. Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and non-obese subjects. Diabetes Care. 2007;30:1802–6.CrossRefPubMed Broch M, Vendrell J, Ricart W, et al. Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and non-obese subjects. Diabetes Care. 2007;30:1802–6.CrossRefPubMed
8.
Zurück zum Zitat Von Eynatten M, Lepper PM, Liu D, et al. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia. 2007;50:1930–7.CrossRef Von Eynatten M, Lepper PM, Liu D, et al. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia. 2007;50:1930–7.CrossRef
9.
Zurück zum Zitat Qi Q, Yu Z, Ye X, et al. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007;92:4827–34.CrossRefPubMed Qi Q, Yu Z, Ye X, et al. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007;92:4827–34.CrossRefPubMed
10.
Zurück zum Zitat Haider DG, Schindler K, Prager G, et al. Serum retinol-binding protein-4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrin Metab. 2007;92:1168–71.CrossRef Haider DG, Schindler K, Prager G, et al. Serum retinol-binding protein-4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrin Metab. 2007;92:1168–71.CrossRef
11.
Zurück zum Zitat Gomez-Ambrosi J, Rodriguez A, Catalán V, et al. Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass. Clin Endocrinol. 2008;69:208–15.CrossRef Gomez-Ambrosi J, Rodriguez A, Catalán V, et al. Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass. Clin Endocrinol. 2008;69:208–15.CrossRef
12.
Zurück zum Zitat Balagopal P, Graham TE, Kahn BB, et al. Reduction of elevated serum retinol binding protein (RBP4) in obese children by lifestyle intervention: association with sub-clinical inflammation. J Clin Endocrinol Metab. 2007;92:1971–4.CrossRefPubMed Balagopal P, Graham TE, Kahn BB, et al. Reduction of elevated serum retinol binding protein (RBP4) in obese children by lifestyle intervention: association with sub-clinical inflammation. J Clin Endocrinol Metab. 2007;92:1971–4.CrossRefPubMed
13.
Zurück zum Zitat Vitkota M, Klimcakova E, Kovacikova M, et al. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab. 2007;92:2330–5.CrossRef Vitkota M, Klimcakova E, Kovacikova M, et al. Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab. 2007;92:2330–5.CrossRef
14.
Zurück zum Zitat Ng TW, Watts GF, Barret PH, et al. Effect of weight loss on LDL and HDL kinetics in the metabolic syndrome. Diabetes Care. 2007;30:2945–50.CrossRefPubMed Ng TW, Watts GF, Barret PH, et al. Effect of weight loss on LDL and HDL kinetics in the metabolic syndrome. Diabetes Care. 2007;30:2945–50.CrossRefPubMed
15.
Zurück zum Zitat Lee JW, Lee HR, Shim JY, et al. Abdominal visceral fat reduction is associated with favorable changes of retinol binding protein-4 in nondiabetic subjects. Endocr J. 2008;55:811–8.CrossRefPubMed Lee JW, Lee HR, Shim JY, et al. Abdominal visceral fat reduction is associated with favorable changes of retinol binding protein-4 in nondiabetic subjects. Endocr J. 2008;55:811–8.CrossRefPubMed
16.
Zurück zum Zitat Reinehr T, Stoffel-Wagner B, Roth CL. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab. 2008;93:2287–93.CrossRefPubMed Reinehr T, Stoffel-Wagner B, Roth CL. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab. 2008;93:2287–93.CrossRefPubMed
17.
Zurück zum Zitat Janke J, Engeli S, Boschmann M, et al. Retinol-binding protein in human obesity. Diabetes. 2006;55:2805–10.CrossRefPubMed Janke J, Engeli S, Boschmann M, et al. Retinol-binding protein in human obesity. Diabetes. 2006;55:2805–10.CrossRefPubMed
18.
Zurück zum Zitat Yang RZ, Lee MJ, Hu H. Retinol binding protein 4: serum concentrations, adipose secretion, and its relationship to obesity. Diabetes. 2006;55:87A. Abstract. Yang RZ, Lee MJ, Hu H. Retinol binding protein 4: serum concentrations, adipose secretion, and its relationship to obesity. Diabetes. 2006;55:87A. Abstract.
19.
Zurück zum Zitat Capella RF, Capella JF. Reducing early technical complications in gastric by-pass surgery. Obes Surg. 1997;7:149–57.CrossRefPubMed Capella RF, Capella JF. Reducing early technical complications in gastric by-pass surgery. Obes Surg. 1997;7:149–57.CrossRefPubMed
20.
Zurück zum Zitat Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med. 1998;15:539–53.CrossRefPubMed Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med. 1998;15:539–53.CrossRefPubMed
21.
Zurück zum Zitat Friedewald WT, Levi RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the ultracentrifuge. Clin Chem. 1972;18:499–502.PubMed Friedewald WT, Levi RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the ultracentrifuge. Clin Chem. 1972;18:499–502.PubMed
22.
Zurück zum Zitat Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.CrossRefPubMed Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.CrossRefPubMed
23.
Zurück zum Zitat Fernández-Real JM, Molina A, Broch M, et al. Tumor necrosis factor system activity is associated with insulin resistance and dyslipemia in myotonic dystrophy. Diabetes. 1999;48:1108–12.CrossRefPubMed Fernández-Real JM, Molina A, Broch M, et al. Tumor necrosis factor system activity is associated with insulin resistance and dyslipemia in myotonic dystrophy. Diabetes. 1999;48:1108–12.CrossRefPubMed
24.
Zurück zum Zitat Ross R, Janiszewski PM. Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction? Can J Cardiol. 2008;24:25D–31D.PubMed Ross R, Janiszewski PM. Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction? Can J Cardiol. 2008;24:25D–31D.PubMed
25.
Zurück zum Zitat Cho YM, Youn BS, Lee H, et al. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care. 2006;29:2457–61.CrossRefPubMed Cho YM, Youn BS, Lee H, et al. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care. 2006;29:2457–61.CrossRefPubMed
26.
Zurück zum Zitat Gavi S, Stuart LM, Kelly P, et al. Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes. J Clin Endocrinol Metab. 2007;92:1886–90.CrossRefPubMed Gavi S, Stuart LM, Kelly P, et al. Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes. J Clin Endocrinol Metab. 2007;92:1886–90.CrossRefPubMed
27.
Zurück zum Zitat Giannessi D, Maltinti M, Del Ry S. Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk. Pharmacol Res. 2007;56:459–67.CrossRefPubMed Giannessi D, Maltinti M, Del Ry S. Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk. Pharmacol Res. 2007;56:459–67.CrossRefPubMed
28.
Zurück zum Zitat Ghraham TE, Wason CJ, Blüher M, et al. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50:814–23.CrossRef Ghraham TE, Wason CJ, Blüher M, et al. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50:814–23.CrossRef
29.
Zurück zum Zitat Antuna-Puente B, Faraj M, Karelis AD, et al. HOMA or QUICKI: is it useful to test the reproducibility of formulas? Diabetes Metab. 2008;34:294–6.CrossRefPubMed Antuna-Puente B, Faraj M, Karelis AD, et al. HOMA or QUICKI: is it useful to test the reproducibility of formulas? Diabetes Metab. 2008;34:294–6.CrossRefPubMed
30.
Zurück zum Zitat Munkhtulga L, Nakayama K, Utsumi N, et al. Identification of a 409 regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia. Hum Genet. 2007;120:879–88.CrossRefPubMed Munkhtulga L, Nakayama K, Utsumi N, et al. Identification of a 409 regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia. Hum Genet. 2007;120:879–88.CrossRefPubMed
31.
Zurück zum Zitat Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338–44.CrossRefPubMed Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338–44.CrossRefPubMed
32.
Zurück zum Zitat Kovacs P, Geyer M, Berndt J, et al. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. Diabetes. 2007;56:3095–100.CrossRefPubMed Kovacs P, Geyer M, Berndt J, et al. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. Diabetes. 2007;56:3095–100.CrossRefPubMed
33.
Zurück zum Zitat van Hoek M, Dehghan A, Zillikens MC, et al. An RBP4 promoter polymorphism increases risk of type 2 diabetes. Diabetologia. 2008;51:1423–8.CrossRefPubMed van Hoek M, Dehghan A, Zillikens MC, et al. An RBP4 promoter polymorphism increases risk of type 2 diabetes. Diabetologia. 2008;51:1423–8.CrossRefPubMed
34.
Zurück zum Zitat Ribel-Madsen R, Friedrichsen M, Vaag A, et al. Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action. Diabetes. 2009;58:54–60.CrossRefPubMed Ribel-Madsen R, Friedrichsen M, Vaag A, et al. Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action. Diabetes. 2009;58:54–60.CrossRefPubMed
35.
Zurück zum Zitat Gerber LE, Erdman JW. Retinoic acid and hipertriglyceridemia. Ann N Y Acad Sci. 1981;359:391–2.CrossRefPubMed Gerber LE, Erdman JW. Retinoic acid and hipertriglyceridemia. Ann N Y Acad Sci. 1981;359:391–2.CrossRefPubMed
36.
37.
Zurück zum Zitat Shea JL, Loredo-Osti CL, Sun G. Association of RBP4 gene variants and serum HDL cholesterol levels in the Newfoundland population. Obesity. 2009;5:398–403. Shea JL, Loredo-Osti CL, Sun G. Association of RBP4 gene variants and serum HDL cholesterol levels in the Newfoundland population. Obesity. 2009;5:398–403.
38.
Zurück zum Zitat Wu Y, Li H, Loos RJ, et al. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res. 2009;50:1479–86.CrossRefPubMed Wu Y, Li H, Loos RJ, et al. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res. 2009;50:1479–86.CrossRefPubMed
39.
Zurück zum Zitat Broch M, Auguet MT, Ramírez R, et al. Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects. Eur J Endocrinol. 2009;161:87–94.CrossRefPubMed Broch M, Auguet MT, Ramírez R, et al. Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects. Eur J Endocrinol. 2009;161:87–94.CrossRefPubMed
40.
Zurück zum Zitat Soprano DR, Soprano KJ, Goodman DS. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. J Lipid Res. 1986;27:166–71.PubMed Soprano DR, Soprano KJ, Goodman DS. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. J Lipid Res. 1986;27:166–71.PubMed
41.
Zurück zum Zitat Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev. 1989;10:308–16.CrossRefPubMed Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev. 1989;10:308–16.CrossRefPubMed
42.
Zurück zum Zitat Suhara A, Kato M, Kanai M. Ultrastructural localization of plasma retinol-binding protein in rat liver. J Lipid Res. 1990;31:1669–81.PubMed Suhara A, Kato M, Kanai M. Ultrastructural localization of plasma retinol-binding protein in rat liver. J Lipid Res. 1990;31:1669–81.PubMed
Metadaten
Titel
Association of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women
verfasst von
Montserrat Broch
José Manuel Gómez
Ma Teresa Auguet
Nuria Vilarrasa
Rosa Pastor
Iñaki Elio
Montserrat Olona
Antonio García-España
Cristóbal Richart
Publikationsdatum
01.09.2010
Verlag
Springer-Verlag
Erschienen in
Obesity Surgery / Ausgabe 9/2010
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-010-0200-5

Weitere Artikel der Ausgabe 9/2010

Obesity Surgery 9/2010 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.