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Erschienen in: Obesity Surgery 3/2012

01.03.2012 | Clinical Research

Is Laparoscopic Duodenojejunal Bypass with Sleeve an Effective Alternative to Roux En Y Gastric Bypass in Morbidly Obese Patients: Preliminary Results of a Randomized Trial

verfasst von: P. Praveen Raj, R. Kumaravel, C. Chandramaliteeswaran, S. Rajpandian, C. Palanivelu

Erschienen in: Obesity Surgery | Ausgabe 3/2012

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Abstract

Background

The incidence of obesity and related metabolic disorders in India and that of stomach carcinoma is one of the highest in the world. Hence, one requires a procedure that allows postoperative surveillance of the stomach with the best outcomes in terms of weight control and resolution of co-morbidities. Here, we compare one such procedure, duodenojejunal bypass with sleeve against the standard Roux-en Y gastric bypass.

Methods

Fifty-seven patients who were selected for a bypass procedure were randomized into two groups of laparoscopic duodenojejunal bypass with sleeve (DJB) and laparoscopic Roux en Y gastric bypass. The limb lengths were similar in both the groups, and the sleeve was done over a 36F bougie.

Results

The mean body mass index and percent excess weight loss at the end of 3, 6, and 12 months between the groups were not statistically significant. The operating times were higher in the DJB group. The rate of resolution of diabetes, hypertension, and dyslipidemias were also similar with no statistical significance. There was 100% resolution of dyslipidemias in both groups. There was one patient in the DJB group who presented with internal herniation 1 month post-op and was managed surgically. There was no mortality in both the groups.

Conclusion

Laparoscopic duodenojejunal with sleeve gastrectomy, a procedure which combines the principles and advantages of sleeve gastrectomy and foregut hypothesis, is a safe and effective alternative to gastric bypass in weight reduction and resolution of co-morbidities especially for Asian countries. But, long-term follow-up is required.
Literatur
1.
Zurück zum Zitat US Census Bureau. International database. 2004. US Census Bureau. International database. 2004.
2.
Zurück zum Zitat WHO. Prevalence of diabetes in the world. 2003. WHO. Prevalence of diabetes in the world. 2003.
3.
Zurück zum Zitat Beckman LM, Beckman TR, Earthman CP. Changes in gastrointestinal hormones and leptin after Roux en Y gastric bypass procedure: a review. Am Diet Assoc. 2010;110(4):571–84.CrossRef Beckman LM, Beckman TR, Earthman CP. Changes in gastrointestinal hormones and leptin after Roux en Y gastric bypass procedure: a review. Am Diet Assoc. 2010;110(4):571–84.CrossRef
4.
Zurück zum Zitat Pories WJ, Albrecht RJ. Etiology of type II diabetes mellitus: role of the foregut. World J Surg. 2001;25:527–31.PubMedCrossRef Pories WJ, Albrecht RJ. Etiology of type II diabetes mellitus: role of the foregut. World J Surg. 2001;25:527–31.PubMedCrossRef
5.
Zurück zum Zitat Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals the role of proximal small intestines in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244:741–9.PubMedCrossRef Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals the role of proximal small intestines in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244:741–9.PubMedCrossRef
6.
Zurück zum Zitat Wittgrove AC, Clark GW. Laparoscopic gastric bypass, Roux en Y-500 patients: technique and results, with 3–60 month follow up. Obes Surg. 2000;10(3):233–9.PubMedCrossRef Wittgrove AC, Clark GW. Laparoscopic gastric bypass, Roux en Y-500 patients: technique and results, with 3–60 month follow up. Obes Surg. 2000;10(3):233–9.PubMedCrossRef
7.
Zurück zum Zitat Higa KD, Boone KB, Ho T. Complications of the laparoscopic Roux en Y gastric bypass: 1040 patients—what have we learned? Obes Surg. 2000;10(6):509–13.PubMedCrossRef Higa KD, Boone KB, Ho T. Complications of the laparoscopic Roux en Y gastric bypass: 1040 patients—what have we learned? Obes Surg. 2000;10(6):509–13.PubMedCrossRef
8.
Zurück zum Zitat Higa KD, Ho T, Boone KB. Laparoscopic Roux en Y gastric bypass: technique and 3-year follow up. J Laparoendosc Adv Surg Tech A. 2001;11(6):377–82.PubMedCrossRef Higa KD, Ho T, Boone KB. Laparoscopic Roux en Y gastric bypass: technique and 3-year follow up. J Laparoendosc Adv Surg Tech A. 2001;11(6):377–82.PubMedCrossRef
9.
Zurück zum Zitat Schauer PR, Ikramuddin S, Gourash W, et al. Outcomes after laparoscopic Roux en Y gastric bypass for morbid obesity. Ann Surg. 2000;232(4):515–29.PubMedCrossRef Schauer PR, Ikramuddin S, Gourash W, et al. Outcomes after laparoscopic Roux en Y gastric bypass for morbid obesity. Ann Surg. 2000;232(4):515–29.PubMedCrossRef
10.
Zurück zum Zitat Tagaya N, Kasama K, Inamine S, et al. Evaluation of the excluded stomach by double-balloon endoscopy after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2007;17:1165–70.PubMedCrossRef Tagaya N, Kasama K, Inamine S, et al. Evaluation of the excluded stomach by double-balloon endoscopy after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2007;17:1165–70.PubMedCrossRef
11.
Zurück zum Zitat National Cancer Registry Programme (India). Consolidated report of hospital based cancer registries 2001–2003. National Cancer Registry Programme (India). Consolidated report of hospital based cancer registries 2001–2003.
12.
Zurück zum Zitat Swaminathan R, Selvakumaran R, Esmy PO, et al. Cancer pattern and survival in a rural district in South India. Cancer Epidemiol. 2009;33(5):325–31.PubMedCrossRef Swaminathan R, Selvakumaran R, Esmy PO, et al. Cancer pattern and survival in a rural district in South India. Cancer Epidemiol. 2009;33(5):325–31.PubMedCrossRef
13.
Zurück zum Zitat Sambasivaiah K, Ibrarullah M, Reddy MK, et al. Clinical profile of carcinoma stomach at a tertiary care hospital in South India. Trop Gastroenterol. 2004;25(1):21–6.PubMed Sambasivaiah K, Ibrarullah M, Reddy MK, et al. Clinical profile of carcinoma stomach at a tertiary care hospital in South India. Trop Gastroenterol. 2004;25(1):21–6.PubMed
14.
Zurück zum Zitat O’Connor EA, Carlin AM. Lack of correlation between small volume gastric pouch size and weight loss after laparoscopic Roux en Y gastric bypass. SOARD 2008;399–403. O’Connor EA, Carlin AM. Lack of correlation between small volume gastric pouch size and weight loss after laparoscopic Roux en Y gastric bypass. SOARD 2008;399–403.
15.
Zurück zum Zitat Kinra S, Bowen LJ, Lyngdoh T, et al. Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross sectional study. BMJ. 2010;341:4974.CrossRef Kinra S, Bowen LJ, Lyngdoh T, et al. Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross sectional study. BMJ. 2010;341:4974.CrossRef
16.
Zurück zum Zitat Praveen Raj P, Chandramaliteeswaran C, Senthilnathan P, et al. Bariatric to metabolic surgery: management options and experience at a tertiary centre. J Indian Med Assoc. 2010;108:645–7.PubMed Praveen Raj P, Chandramaliteeswaran C, Senthilnathan P, et al. Bariatric to metabolic surgery: management options and experience at a tertiary centre. J Indian Med Assoc. 2010;108:645–7.PubMed
17.
18.
Zurück zum Zitat Stefanidis D, Kuwada TS, Gersin KS. The importance of the limb length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21(1):119–24.PubMedCrossRef Stefanidis D, Kuwada TS, Gersin KS. The importance of the limb length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21(1):119–24.PubMedCrossRef
19.
Zurück zum Zitat Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef
20.
Zurück zum Zitat Pories W, Swanson M, Macdonald K, et al. Who would have thought it? An effective operation proves to be the most effective therapy for adult onset diabetes mellitus. Ann Surg. 1995;222:339–52.PubMedCrossRef Pories W, Swanson M, Macdonald K, et al. Who would have thought it? An effective operation proves to be the most effective therapy for adult onset diabetes mellitus. Ann Surg. 1995;222:339–52.PubMedCrossRef
21.
Zurück zum Zitat Rubino F, Zizzari P, Tomasetto C, et al. The role of the small bowel in the regulation of circulating Ghrelin levels and food intake in the obese Zucker rat. Endocrinology. 2005;146:1745–51.PubMedCrossRef Rubino F, Zizzari P, Tomasetto C, et al. The role of the small bowel in the regulation of circulating Ghrelin levels and food intake in the obese Zucker rat. Endocrinology. 2005;146:1745–51.PubMedCrossRef
22.
Zurück zum Zitat Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239:1–11.PubMedCrossRef Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239:1–11.PubMedCrossRef
23.
Zurück zum Zitat Pacheco D, de Luis DA, Romero A, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto–Kakizaki rats. Am J Surg. 2007;194:221–4.PubMedCrossRef Pacheco D, de Luis DA, Romero A, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto–Kakizaki rats. Am J Surg. 2007;194:221–4.PubMedCrossRef
24.
Zurück zum Zitat Wang TT, Hu SY, Gao HD, et al. Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann Surg. 2008;247:968–75.PubMedCrossRef Wang TT, Hu SY, Gao HD, et al. Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann Surg. 2008;247:968–75.PubMedCrossRef
25.
Zurück zum Zitat Lakdawala MA, Bhasker A, Mulchandani D, et al. Comparison between the results of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass in the Indian population: a retrospective 1 year study. Obes Surg. 2010;20(1):1–6. Epub 2009 Oct 3.PubMedCrossRef Lakdawala MA, Bhasker A, Mulchandani D, et al. Comparison between the results of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass in the Indian population: a retrospective 1 year study. Obes Surg. 2010;20(1):1–6. Epub 2009 Oct 3.PubMedCrossRef
26.
Zurück zum Zitat Shah SS, Todkar JS, Shah PS, et al. Diabetes remission and reduced cardiovascular risk after gastric bypass in Asian Indians with body mass index <35 kg/m(2). Surg Obes Relat Dis. 2010;6(4):332–8. Epub 2009 Sep 3.PubMedCrossRef Shah SS, Todkar JS, Shah PS, et al. Diabetes remission and reduced cardiovascular risk after gastric bypass in Asian Indians with body mass index <35 kg/m(2). Surg Obes Relat Dis. 2010;6(4):332–8. Epub 2009 Sep 3.PubMedCrossRef
27.
Zurück zum Zitat Csendes A, Burdiles P, Papapietro K, et al. Results of gastric bypass plus resection of the distal excluded gastric segment in patients with morbid obesity. J Gastrointest Surg. 2005;9(1):121–31.PubMedCrossRef Csendes A, Burdiles P, Papapietro K, et al. Results of gastric bypass plus resection of the distal excluded gastric segment in patients with morbid obesity. J Gastrointest Surg. 2005;9(1):121–31.PubMedCrossRef
28.
Zurück zum Zitat Khitin L, Roses RE, Birkett DH. Cancer in the gastric remnant after gastric bypass; a case report. Curr Surg. 2003;60(5):521–3.PubMedCrossRef Khitin L, Roses RE, Birkett DH. Cancer in the gastric remnant after gastric bypass; a case report. Curr Surg. 2003;60(5):521–3.PubMedCrossRef
29.
Zurück zum Zitat Escalona A, Guzman S, Ibanez L, et al. Gastric cancer after Roux-en-Y gastric bypass. Obes Surg. 2005;15(3):423–7.PubMedCrossRef Escalona A, Guzman S, Ibanez L, et al. Gastric cancer after Roux-en-Y gastric bypass. Obes Surg. 2005;15(3):423–7.PubMedCrossRef
30.
Zurück zum Zitat Padoin AV, Galvao Neto M, Moretto M, et al. Obese patients with type 2 diabetes submitted to banded gastric bypass: greater incidence of dumping syndrome. Obes Surg. 2009;19:1481–4.PubMedCrossRef Padoin AV, Galvao Neto M, Moretto M, et al. Obese patients with type 2 diabetes submitted to banded gastric bypass: greater incidence of dumping syndrome. Obes Surg. 2009;19:1481–4.PubMedCrossRef
31.
Zurück zum Zitat Loss AB, de Souza AA, Pitombo CA, et al. Analysis of the dumping syndrome on morbid obese patients submitted to Roux en Y gastric bypass. Rev Col Bras Cir. 2009;36(5):413–9.PubMedCrossRef Loss AB, de Souza AA, Pitombo CA, et al. Analysis of the dumping syndrome on morbid obese patients submitted to Roux en Y gastric bypass. Rev Col Bras Cir. 2009;36(5):413–9.PubMedCrossRef
32.
Zurück zum Zitat Kasama K, Tagaya N, Kanehira E, et al. Laparoscopic sleeve gastrectomy with duodenojejunal bypass: technique and preliminary results. Obes Surg. 2009;19:1341–5.PubMedCrossRef Kasama K, Tagaya N, Kanehira E, et al. Laparoscopic sleeve gastrectomy with duodenojejunal bypass: technique and preliminary results. Obes Surg. 2009;19:1341–5.PubMedCrossRef
33.
Zurück zum Zitat Navarrete SA, Leyba JL, Llopis SN. Laparoscopic sleeve gastrectomy with duodenojejunal bypass for the treatment of type 2 diabetes in non-obese patients: technique and preliminary results. Obes Surg. 2011;21(5):663–7.PubMedCrossRef Navarrete SA, Leyba JL, Llopis SN. Laparoscopic sleeve gastrectomy with duodenojejunal bypass for the treatment of type 2 diabetes in non-obese patients: technique and preliminary results. Obes Surg. 2011;21(5):663–7.PubMedCrossRef
Metadaten
Titel
Is Laparoscopic Duodenojejunal Bypass with Sleeve an Effective Alternative to Roux En Y Gastric Bypass in Morbidly Obese Patients: Preliminary Results of a Randomized Trial
verfasst von
P. Praveen Raj
R. Kumaravel
C. Chandramaliteeswaran
S. Rajpandian
C. Palanivelu
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Obesity Surgery / Ausgabe 3/2012
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0507-x

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