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Effects of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on Weight Loss and Biomarker Parameters in Morbidly Obese Patients: A 12-Month Follow-Up

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Abstract

Background

Laparoscopic Roux-en-Y gastric bypass (LRYGB) is suggested as the gold standard of the surgical techniques for morbid obesity treatment. The aim of this study was to evaluate the weight loss and biomarker parameter changes over a 1-year period following LRYGB in Iranian morbidly obese patients.

Methods

Sixty patients who had undergone LRYGB from June 2006 to August 2008 were followed up. Complication rates and changes in anthropometric indices, metabolic parameters, and obesity-related comorbidities were evaluated.

Results

During the mean follow-up duration of 27.2 ± 9.4 months, the mean weight reduced from 128.8 ± 20.4 to 86.9 ± 12.7 kg with excess weight loss (%EWL) of 63.8 ± 15.6%. The male young-adolescent patients showed more weight loss than females. Biochemical parameter changes were reduction of fasting blood sugar by 19%, total cholesterol by 17%, triglyceride by 30%, low-density lipoprotein by 19%, aspartate aminotransferase by 44%, alanine aminotransferase by 52%, alkaline phosphatase by 33%, and uric acid by 19%, while high-density lipoprotein (HDL) levels increased by 22%. HDL level change was the only biomarker factor showing correlation with age (P = 0.005, r = −0.353, R 2 = 0.125). Obesity comorbidities were resolved considerably. There were two cases of surgical complications and no case of mortality.

Conclusion

LRYGB appears to be a safe and effective procedure with a low complication rate in Iranian morbidly obese patients. It results in weight loss, reduction in obesity comorbidities, increasing HDL, and decreasing other measured plasma biochemical parameters. Based on our results, we suggest that LRYGB would benefit young male morbidly obese patients more than others.

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Acknowledgments

The authors wish to thank Dr. Foad Ahmadi and Dr. Tohid Emami for their help and comments in preparing this article.

Conflicts of Interest

All contributing authors (K.T., S.A., M.G., and H.A.) declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Karamollah Toolabi

  2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Saeed Arefanian

  3. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mahdieh Golzarand

  4. Endocrinology and Metabolism Research Center, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Hossein Arefanian

  5. No. 26, Chamran Building, Parvaneh Alley, Shahid Gomnam Expressway, Kargar-e-Shomali Street, Tehran, Iran

    Saeed Arefanian

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  1. Karamollah Toolabi
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  4. Hossein Arefanian
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Correspondence to Saeed Arefanian.

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Toolabi, K., Arefanian, S., Golzarand, M. et al. Effects of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on Weight Loss and Biomarker Parameters in Morbidly Obese Patients: A 12-Month Follow-Up. OBES SURG 21, 1834–1842 (2011). https://doi.org/10.1007/s11695-011-0525-8

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