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Erschienen in: Obesity Surgery 7/2012

01.07.2012 | Clinical Research

Effect of Bariatric Surgery on Liver Fibrosis

verfasst von: Myriam Moretto, Carlos Kupski, Vinicius Duval da Silva, Alexandre V. Padoin, Cláudio C. Mottin

Erschienen in: Obesity Surgery | Ausgabe 7/2012

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Abstract

Background

Although bariatric surgery has been shown to improve hepatic steatosis in morbidly obese patients, the effect of weight loss on hepatic fibrosis has not been determined. Since the prognosis of patients with nonalcoholic fatty liver disease is closely related to the development of hepatic fibrosis, it is important to determine the hepatic histology of these patients after weight loss. We therefore evaluated the prevalence of hepatic fibrosis in morbidly obese patients undergoing bariatric surgery and assessed the correlation of histologic changes with weight loss.

Methods

We retrospectively evaluated 78 morbidly obese patients who underwent gastric bypass. Liver biopsies were taken during surgery and after weight loss, and the correlations between histologic findings and hepatic fibrosis were determined.

Results

Of the 78 patients, 35 (44.8%) had fibrosis at first biopsy, and 24 (30.8%) had hepatic fibrosis after weight loss, including 19 of the 35 patients (54.3%) with fibrosis at first biopsy and 5 of the 43 (11.6%) without hepatic fibrosis at first biopsy (P = 0.027).

Conclusions

Weight loss in morbidly obese patients was associated with a reduction in the prevalence of hepatic fibrosis.
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Metadaten
Titel
Effect of Bariatric Surgery on Liver Fibrosis
verfasst von
Myriam Moretto
Carlos Kupski
Vinicius Duval da Silva
Alexandre V. Padoin
Cláudio C. Mottin
Publikationsdatum
01.07.2012
Verlag
Springer-Verlag
Erschienen in
Obesity Surgery / Ausgabe 7/2012
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0559-y

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