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Erschienen in:
01.02.2014 | Original Contributions
Six-Month Intragastric Balloon Treatment for Obesity Improves Lung Function, Body Composition, and Metabolic Syndrome
Erschienen in: Obesity Surgery | Ausgabe 2/2014
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Background
The purpose of this study is to establish whether the use of an intragastric balloon (IGB) for 6 months improves lung function, metabolic parameters, and body fat distribution in patients with overweight/obesity and metabolic syndrome (MS).
Methods
This is a longitudinal and interventional study on 40 adults, whose anthropometric, laboratory, and lung function parameters were assessed and who underwent dual-energy X-ray absorptiometry (DXA) before implantation and after removal of IGB.
Results
The total lung capacity (TLC) (p = 0.0001), functional residual capacity (FRC) (p = 0.0001), residual volume (p = 0.0005), and expiratory reserve volume (ERV) (p = 0.0001) were significantly reduced by IGB. The body mass index (BMI) significantly decreased from a median of 39.1 kg/m2 at the beginning of the study to 34.5 kg/m2 at the end of the 6-month period (p = 0.0001). At the end of the study, 31 participants (77.5 %) no longer met the diagnostic criteria of MS. The percentage of truncal, android, gynoid, and total fat investigated by DXA exhibited significant reductions (p = 0.0001). Significant correlations were found between delta TLC and delta waist circumference (ρ = −0.34; p = 0.03), delta FRC and delta IMC (ρ = −0.39; p = 0.01), delta ERV and delta BMI (ρ = −0.44; p = 0.005), and delta ERV and delta high-density lipoprotein (HDL) (ρ = −0.37; p = 0.02). Significant correlations were also found between delta ERV and delta truncal (ρ = −0.51; p = 0.004), android (ρ = −0.46; p = 0.01), gynoid (ρ = −0.55; p = 0.001), and total fat (ρ = −0.59; p = 0.0005).
Conclusions
IGB efficiently induced weight loss and promoted the improvement of lung function parameters, with a reduction of the restrictive ventilatory defect. It also promoted improvements of MS and the pattern of body fat distribution.