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Erschienen in: Obesity Surgery 1/2015

01.01.2015 | Original Contributions

Coronary Calcium Scores 6 Years After Bariatric Surgery

verfasst von: Tiffany Priester, Travis G. Ault, Lance Davidson, Richard Gress, Ted D. Adams, Steven C. Hunt, Sheldon E. Litwin

Erschienen in: Obesity Surgery | Ausgabe 1/2015

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Abstract

Background

Obesity is associated with elevated coronary artery calcium (CAC), a marker of coronary atherosclerosis that is strongly predictive of cardiovascular events. We evaluated the effects of marked weight loss achieved through Roux-en-Y gastric bypass surgery (GBS) on CAC scores.

Methods

We performed echocardiography and computed tomography of the heart in 149 subjects 6 years after enrollment in a prospective registry evaluating the cardiovascular effects of GBS. Coronary calcium scores, left ventricular ejection fraction, and left ventricular mass were measured.

Results

At baseline, most coronary risk factors were similar between the GBS and nonsurgical groups including current smoking, systolic blood pressure, LDL-C, HDL-C, and TG. However, GBS patients were younger (4.7 years), less likely to be diabetic, and less likely to be postmenopausal. At 6 years after enrollment, CAC score was significantly lower in patients who underwent GBS than those without surgery (p < 0.01). GBS subjects had a lower likelihood of having measureable coronary calcium (odds ratio of CAC > 0 = 0.39; 95 % CI of (0.17, 0.90)). Significant predictors of 0 CAC were GBS, female gender, younger age, baseline BMI, and baseline LDL-C. Substituting change in BMI for group status as a predictor variable showed that BMI change also predicted CAC (p = 0.045). Changes in LDL-C did not predict the CAC differences between groups (p = 0.67).

Conclusions

Sustained weight loss achieved through bariatric surgery is associated with less coronary calcification. This effect, which appears to be independent of changes in LDL-C, may contribute to lower cardiac mortality in patients with successful GBS.
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Metadaten
Titel
Coronary Calcium Scores 6 Years After Bariatric Surgery
verfasst von
Tiffany Priester
Travis G. Ault
Lance Davidson
Richard Gress
Ted D. Adams
Steven C. Hunt
Sheldon E. Litwin
Publikationsdatum
01.01.2015
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 1/2015
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1327-6

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