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06.03.2017 | Review Article

Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis

verfasst von: Dimitrios E. Magouliotis, Vasiliki S. Tasiopoulou, Eleni Sioka, Christina Chatedaki, Dimitrios Zacharoulis

Erschienen in: Obesity Surgery | Ausgabe 5/2017

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Abstract

We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Twenty-two studies (562 patients) met the inclusion criteria. This study points to significant amelioration of postoperative levels of glucose, insulin, triglycerides, total cholesterol, LDL, HDL, HOMA-IR, food intake, and diabetes remission. Branched-chain amino acids (BCAAs) decreased, while trimethylamine-n-oxide (TMAO); glucagon-like peptide 1, 2 (GLP-1, GLP-2); and peptide YY (PYY) increased postoperatively. Postoperative gut microbiota was similar to that of lean and less obese objects. Well-designed randomized trials are necessary to further assess the host metabolic-microbial cross-talk after bariatric procedures.

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Titel: Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis
verfasst von: Dimitrios E. Magouliotis
Vasiliki S. Tasiopoulou
Eleni Sioka
Christina Chatedaki
Dimitrios Zacharoulis
Publikationsdatum: 06.03.2017
Verlag: Springer US
Erschienen in: Obesity Surgery / Ausgabe 5/2017
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-017-2595-8

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