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Erschienen in: Obesity Surgery 4/2019

05.02.2019 | Original Contribution

Monogenic Obesity Mutations Lead to Less Weight Loss After Bariatric Surgery: a 6-Year Follow-Up Study

verfasst von: Yangyang Li, Hong Zhang, Yinfang Tu, Chen Wang, Jianzhong Di, Haoyong Yu, Pin Zhang, Yuqian Bao, Weiping Jia, Jianjun Yang, Cheng Hu

Erschienen in: Obesity Surgery | Ausgabe 4/2019

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Abstract

Objectives

Bariatric surgery is emerging as the most effective treatment option for patients with obesity. Hypothalamic arcuate nucleus plays an important role in metabolic homeostasis. However, the influence of mutations related to the feeding center on weight loss after bariatric surgery is still unclear. We aimed to diagnose monogenic obesity by whole exome sequencing (WES) and explore whether monogenic mutations influence the effectiveness of bariatric surgery.

Methods

We collected obese patients aged 15 to 55 with a BMI > 28 kg/m2 and who underwent laparoscopic sleeve gastrectomy from March 2011 to June 2017 in Shanghai. Data related to weight loss and metabolic characteristics preoperatively and postoperatively were collected, including fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. WES was performed in obese patients using genomic DNA from whole blood samples.

Results

We investigated the proportion of 131 obese adults with one mutation as high as to 8.4% and then evaluated the association between these mutations and weight loss. Mutation carriers had less weight loss over both short-term and long-term periods. Survival analyses indicated it was harder to attain the goal of 20% weight loss for mutation carriers (Plog-rank = 0.001; Pbreslow < 0.001), and the difference remained significant with a Cox regression model. Improvement in FBG, HDL cholesterol, and triglyceride levels postoperatively was observed in both groups, while there were significant differences between the two groups.

Conclusions

Our data indicated that 8.4% of obesity cases were caused by change in genetics, and mutations had negative effects on the efficacy of bariatric surgery.
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Metadaten
Titel
Monogenic Obesity Mutations Lead to Less Weight Loss After Bariatric Surgery: a 6-Year Follow-Up Study
verfasst von
Yangyang Li
Hong Zhang
Yinfang Tu
Chen Wang
Jianzhong Di
Haoyong Yu
Pin Zhang
Yuqian Bao
Weiping Jia
Jianjun Yang
Cheng Hu
Publikationsdatum
05.02.2019
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 4/2019
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-03623-4

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