One Anastomosis/Mini-Gastric Bypass (OAGB/MGB) as Revisional Surgery Following Primary Restrictive Bariatric Procedures: a Systematic Review and Meta-Analysis
verfasst von:
Mohammad Kermansaravi, Shahab Shahabi Shahmiri, Amir Hossein DavarpanahJazi, Rohollah Valizadeh, Giovanna Berardi, Antonio Vitiello, Mario Musella, Miguel Carbajo
One anastomosis gastric bypass (OAGB/MGB) has gained popularity in the past decade. International databases were searched for articles published by September 10, 2020, on OAGB/MGB as a revisional procedure after restrictive procedures. Twenty-six studies examining a total of 1771 patients were included. The mean initial BMI was 45.70 kg/m2, which decreased to 31.52, 31.40, and 30.54 kg/m2 at 1, 3, and 5-year follow-ups, respectively. Remission of type-2 diabetes mellitus (T2DM) following OAGB/MGB at 1-, 3-, and 5-year follow-up was 65.16 ± 24.43, 65.37 ± 36.07, and 78.10 ± 14.19%, respectively. Remission/improvement rate from gastroesophageal reflux disease (GERD). Also, 7.4% of the patients developed de novo GERD following OAGB/MGB. Leakage was the most common major complication. OAGB/MGB appears to be feasible and effective as a revisional procedure after failed restrictive bariatric procedures.
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Introduction
In last years, bariatric surgery has proven to be the most effective treatment for morbid obesity and obesity-related diseases, providing long-standing effects and presenting a very low complication rate [1‐3]. One anastomosis gastric bypass was firstly introduced by Rutledge as mini-gastric bypass (MGB) in 2001 [4] and subsequently modified as OAGB by Carbajo in 2005 [5]. It is currently an accepted bariatric procedure named as OAGB/MGB by IFSO [6], which has gained increasing popularity among bariatric surgeons worldwide [7]; efficacy and safety of primary OAGB/MGB have been reported in many different papers [8‐12]. Due to the growing request for revisional bariatric surgery that recorded a steep increase in last years, rising from 6 to 13.6% of all bariatric procedures, a number of articles about conversional OAGB/MGB following primary restrictive procedures have been already published. Current revisional surgery rates are in fact reported to range from 9.8% for laparoscopic sleeve gastrectomy, to 26% for laparoscopic adjustable gastric banding [13]. Although a systematic review of the studies reporting results and complications of conversional OAGB/MGB has been very recently released [14], a study offering an analytic approach to conversional OAGB/MGB following laparoscopic adjustable gastric banding (LAGB), laparoscopic sleeve gastrectomy (LSG), and vertical banded gastroplasty (VBG) is still lacking. Aim of this study is therefore to define through a meta-analysis the role of OAGB/MGB as a conversional procedure after failed restrictive procedures, such as LAGB, LSG, and VBG.
Methods
A literature search was carried out based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines [15] (see supplementary material). PubMed, Cochrane, and Scopus were consulted for articles published by September 10, 2020, on OAGB/MGB as a revisional procedure following restrictive procedures. The keywords searched were “One anastomosis gastric bypass,” “OAGB,” “Single-anastomosis gastric bypass,” “Weight regain,” “Weight loss,” “Conversion,” “Mini gastric bypass,” “MGB,” “Failure,” “Redo,” “Revisional surgery,” “Conversional surgery,” “omega loop gastric bypass,” or “loop gastric bypass,” “revisional bariatric surgery,” “secondary bariatric surgery,” “revisional sleeve gastrectomy,” “band to bypass,” “revision to bypass,” or a combination of them in the titles or abstracts. The search strategy for can be found in the supplementary files. Two of the authors independently assessed the eligibility of the papers according to the PRISMA guidelines. The references of the articles were manually reviewed for additional relevant papers. The duplicate studies were removed.
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Statistical Analysis
The effect of revisional surgery on body mass index (BMI) was assessed using the standardized mean difference (SMD), also known as Cohen’s D. The SMD was calculated by using the mean difference and standard deviations (SD) before and after the surgery based on the SMD formula (SMD = mean difference in the intervention group − mean difference in the placebo group/pooled SD), and the pooled SD was calculated as √ [(SD in the intervention group) 2 + (SD in the placebo group) 2/2]. Q-test and I2 were used to assess the heterogeneity among the studies. The random-effects model was used for the continuous outcome under study. Also, a random or fixed-effects meta-analysis was applied for estimating the main index, which was the pooled SMD, at 95% confidence interval. A forest plot was used to present the pooled SMD. Publication bias was assessed using Begg’s tests. The analysis was performed using Stats version 13.
Data Extraction
Data on the included articles (author’s name, year of publication, interval to revision, sample size, type of primary surgery, and the outcomes and results of each article) were retrieved by two independent investigators. The differences observed in this process were corrected by a third investigator independent from the other two.
The quality of the selected studies was checked by a quality assessment tool for before-after (pre-post) studies with no control groups [16].
Results
A total of 26 studies [8, 9, 17‐40] examining 1771 patients were included in this meta-analysis (Fig. 1). Since the results of OAGB/MGB were classified and used as a revisional procedure in view of a primary procedure, some articles are quoted in more than one table (Tables 1, 2, and 3).
Fig. 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
Table 1
Study characteristics with primary surgery of LSG included in meta-analysis
The definitions provided for weight regain in the studies were different, but 33.3% of the studies relied on BMI ≥ 35 or EWL ≤ 50%. Also, EBMIL < 50% and EBMIL ≤ 25% were used for defining weight regain in 28.6% of the studies included in this review (Table 4).
Table 4
Type of weight regain definition used in included studies
Weight regain definition
Frequency
Rate %
BMI ≥ 35 or EWL ≤ 50%
7
33.3
BMI ≥ 35
2
9.5
EWL 2 years < 50% or > 25% EWL regain compared with minimal weight
1
4.8
EWL 2 years < 50%
1
4.8
EBMIL < 50%
3
14.3
EBMIL ≤ 25%
3
14.3
EWL < 50% 18 months after surgery
1
4.8
EWL < 50% at 18-month follow-up and EWL < 30% at any time
1
4.8
EWL < 50%, and BMI ≥ 50
1
4.8
EWL < 50% and/or TWL < 25% and/or BMI > 40 at 2 years follow-up
1
4.8
Conversional OAGB/MGB Etiologies
Weight regain and weight loss failure were the most frequent causes of revisional OAGB/MGB. Weight loss failure was reported as the most common etiology for revisional procedure. Other causes included abdominal pain/dyspepsia, port infection, device-related complications, or intolerance to restriction, such as band migration, slippage and port infection, recurrence of type-2 diabetes mellitus, gastroesophageal reflux disease (GERD), dysphagia, and esophageal disorders (Fig. 2).
Fig. 2
Frequency of reported etiologies for revisional OAGB/MGB in included studies
×
Biliopancreatic Limb Length
This review showed that the most common biliopancreatic limb length in OAGB/MGB was 200 cm (36% of the studies). The biliopancreatic limb length varied from 150 to 350 cm (Table 5).
Table 5
Biliopancreatic limb length used in OAGB/MGB surgeries in included studies
Biliopancreatic limb length
Frequency
Rate %
200 cm
9
36
180–200 cm
1
4
180–240 cm
1
4
150 cm and 200 cm
2
8
180 cm
2
8
150–200 cm
1
4
175 -200 cm
1
4
250 cm
1
4
150 cm
2
8
175 cm
1
4
150 cm (and increased by 10 cm for each BMI point above 40)
1
4
150–250 cm
1
4
150–300 cm
1
4
250–350 cm tailored
1
4
Weight Loss Outcomes at 1-, 3-, and 5-Year Follow-Ups
The mean initial BMI was 45.70 kg/m2, which decreased to 31.5, 31.4, and 30.5 kg/m2 at 1-, 3-, and 5-year follow-ups, respectively (Table 6). The forest plots depict the effects of OAGB/MGB on BMI after 1, 3, and 5 years (Figs. 2, 3, 4, and 5).
Table 6
Mean and standard deviation of reported BMI at revision time and follow-up
Variable
Number of patients
Mean ± Std. deviation
At revision BMI (kg/m2)
1584
42.3 ± 2.2
Post-revision BMI ≤ 1 year (kg/m2)
761
31.6 ± 2.5
Post-revision BMI ≤ 3 years (kg/m2)
658
31.4 ± 3.1
Post-revision BMI ≤ 5 years (kg/m2)
505
30.6 ± 2.3
Fig. 3
Forest plot showing the effect of OAGB/MGB on BMI after 1-year follow-up
Fig. 4
Forest plot showing the effect of OAGB/MGB on BMI after 3-year follow-up
Fig. 5
Forest plot showing the effect of OAGB/MGB on BMI after 5-year follow-up
×
×
×
A random effect model was also used to measure the effect of the standardized mean difference (SMD). Based on the results of the included studies, OAGB/MBG has been effective in accomplishing weight loss. Nonetheless, at 1-, 3-, and 5-year follow-ups, BMI decreased by an SMD of − 1.8, − 2.1, and − 1.5, showing the acceptable and durable effects of OAGB/MGB. At the 1-year follow-up, OAGB/MGB following LAGB was most effective in decreasing BMI, with an SMD of − 2.01. Also, OAGB/MGB following LSG (SMD = − 1.7) showed a better effectiveness compared to VBG (SMD = − 1.3). In the 3-year follow-up, OAGB/MGB after LAGB was most effective in decreasing BMI with an SMD of − 2.1. In the 5-year follow-up, OAGB/MGB following LAGB was most effective in decreasing BMI, with an SMD of − 1.7. In this follow-up, conversional OAGB/MGB after VBG (SMD = − 1.4) played an effective role in BMI reduction. The effect of OABG on BMI after a 1-year follow-up with the presence of remnant resection showed no significant difference between the two states (Table 11).
Comorbidity and Remission
The comorbidities included in this meta-analysis were T2DM [3], hypertension (HTN), obstructive sleep apnea (OSA), and dyslipidemia (DL) (Tables 7 and 8).
Table 7
Pre-revision, at revision, and post-revision comorbidities after OAGB/MGB
Remission of HTN, T2DM, OSA, and DL following OAGB/MGB surgery at 1-, 3-, and 5-year follow-up
Post-revision remission rate range
Minimum (%)
Maximum (%)
Mean ± Std. deviation
HTN at 1-year follow-up
42
100
68.5 ± 27.2
T2DM1 at 1-year follow-up
40
88.8
65.2 ± 24.4
OSA at 1-year follow-up
80
80.0
80 ± 0
DL at 1-year follow-up
61
61.5
61.5 ± 0
HTN at 3-year follow-up
21
81.8
49.9 ± 25
T2DM at 3-year follow-up
12
88.8
65.4 ± 36.1
OSA at 3-year follow-up
50
70.0
60 ± 14.1
DL at 3-year follow-up
11
80.6
45.8 ± 49.2
HTN at 5-year follow-up
58
94.0
74.7 ± 16.3
T2DM at 5-year follow-up
62
94.0
78.1 ± 14.2
OSA at 5-year follow-up
82
90.0
86 ± 5.7
DL at 5-year follow-up
75
96.00
85.5 ± 14.8
Diabetes Outcomes
Remission of T2DM following OAGB/MGB surgery at 1-, 3-, and 5-year follow-up was 65.2 ± 24.4, 65.4 ± 36.1, and 78.1 ± 14.2, respectively. The remission range of T2DM at the 1-, 3-, and 5-year follow-ups was 40–88.8%, 12–88.8%, and 62–94%, respectively (Table 8).
HTN Outcomes
Remission of HTN following OAGB/MGB surgery at 1-, 3-, and 5-year follow-ups was 68.4 ± 27.1, 49.9 ± 25, and 74.7 ± 16.2%, respectively. The remission range for HTN at 1-, 3-, and 5-year follow-ups was 42–100%, 21–81.8%, and 58–9%, respectively (Table 8).
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Dyslipidemia Outcomes
Remission of DL following OAGB/MGB surgery at 1-, 3-, and 5-year follow-ups was 61.5 ± 0, 45.8 ± 49.2, and 85.50 ± 14.8, respectively. The remission range for DL at 1-, 3-, and 5-year follow-ups was 61–61.5%, 11–80.6%, and 75–96%, respectively (Table 8).
OSA Outcomes
Remission of OSA following OAGB/MGB surgery at 1-, 3-, and 5-year follow-ups was 80.00 ± 0, 60.00 ± 14.1, and 86.00 ± 5.7, respectively. The remission range for OSA at 1-, 3-, and 5-year follow-ups was 80–80%, 50–70%, and 82–90%, respectively (Table 8).
GERD Outcomes
GERD following OABG surgery was also investigated. The results showed that 81.7% of the patients with GERD improved or had remission following OAGB/MGB (Table 9).
Table 9
Rate of preoperative and postoperative GERD in revisional OAGB/MGB surgery
The results showed that 7.4% of the patients developed de novo GERD following OABG.
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Major Complications
The major complications reported in the studies were extracted, and leakage proved to be the most common problem after revisional OAGB/MGB (0.016). The other complications included hematoma and abscess, GIB, reoperation, strangulated hernia at the trocar port, late incisional hernia, colonic necrosis, bowel obstruction, respiratory failure, anastomotic stricture, hypoalbuminemia, intractable bile reflux, small bowel ileus, pneumonia, GJ stoma fistula, hematemesis, port site infection, and ulceration (Table 10).
Table 10
Major complication rate reported in included studies
Complication
Total complication in 1771 patients
Rate %
Leakage
29
1.6
Bleeding
23
1.2
Hematoma and abscess
12
0.6
GIB
2
0.1
Hypoalbuminaemia
4
0.2
Reoperation
2
0.1
Strangulated hernia at trocar port
2
0.1
Late incisional hernia
4
0.2
Colonic necrosis
1
0.06
Bowel obstruction
3
0.1
Respiratory failure
1
0.06
Stricture
4
0.2
Intractable bile reflux
2
0.1
Small bowel ileus
2
0.1
Pneumonia
1
0.06
GJ stoma fistula
1
0.06
Hematemesis
1
0.06
Port site infection
1
0.06
Ulceration
4
0.2
Publication Bias
The results of the analysis also showed that bias publication did not have an influence on the creation of negative results, which is shown as symmetry in the funnel plot. Meanwhile, no evidence of publication bias was detected using Egger’s test (Egger’s test t = − 2.03, P = 0.06, 95% CI − 3.4 to 0.08).
Discussion
As reported in previously published studies [41, 42], weight loss failure and weight regain may occur in the long term following restrictive procedures. This review study revealed unsuccessful weight loss as the main reason for conversion to OAGB/MGB. All the 57 patients reported by Lessing et al. were converted to OAGB/MGB due to weight regain after gastric banding either by the 1-stage or 2-stage approach [17]. Also, all the reported revisional OAGB/MGBs in Moszkowicz’ series were due to weight regain [18]. In the study by Musella et al., 77% of the restrictive operations (sleeve gastrectomy or banding) were converted due to weight loss failure, and only 23% of the revisions were due to surgical complications (dysphagia, disconnection of tube from the port, port infection and slippage, deterioration of preoperative gastroesophageal reflux (GERD), or de novo GERD) [19]. Band-related complications (slippage, migration, pouch dilation) (43%), esophageal disorders (31%), weight loss failure/persistence of comorbidities (15%), and food intolerance/patient request (11%) were the indications for revisional OAGB/MGB in the other retrieved papers [20].
While insufficient weight loss was the principal reason for conversion, BPL length was found to represent a crucial technical point regarding revisional surgery. Nonetheless, in this review study, BPL varied from 150 to 350 cm, as the optimal limb length in primary and revisional OAGB/MGB is still a matter for debate. The results of this research showed that the most common BPL length in OAGB/MGB was 200 cm (36% of the studies). Meanwhile, some studies used 150-cm BPL lengths (and increased them by 10 cm for each BMI point above 40) [9, 21‐26, 43, 44]. Poghosyan et al. found that weight loss and its outcomes are comparable between the 150-cm and 200-cm BPL [27]. Tovar et al. found that the ideal range was established between 0.40 and 0.43 for the CL/TBL ratio, and 200 and 220 cm for the CL length. Among these ranges, there were no cases of protein or calorie malnutrition [45]; therefore, it is better to measure the entire small intestine and use a maximum one-third of it for GJ to prevent malnutrition.
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Even though further studies are needed to identify the optimal length for primary and revisional OAGB/MGB, the present research demonstrated that, regardless of BPL, conversion from restrictive interventions has resulted in satisfactory and durable outcomes in series with 5-year follow-ups [9, 21, 24, 26‐28]. According to pre and post-revisional BMI between groups, BMI loss was more significant after LAGB compared to OAGB/MGB following LSG or VBG, perhaps due to the lesser weight loss after LAGB as an initial bariatric surgical procedure in comparison with LSG and VBG. This finding may suggest that LAGB can have better post-revisional weight loss outcomes than LSG before gastric bypass [41]. This review of literature also showed that simultaneous gastric remnant resection, which was performed in some of the studies [21, 23, 25, 26, 29], has no significant effects on weight loss, but, in our opinion, it can only increase the risk for postoperative complications and hamper reversal surgery (Table 11).
Table 11
Effect of gastric remnant resection on BMI following revisional OAGB/MGB at 1 year of follow-up
Variable
Remnant resection (n = 319)
Mean
t
P value
Post-revision BMI ≤ 1 year (kg/m2(
Yes
31.6 ± 3.7
− 0.19
0.86
No
31.9 ± 2.2
Post-revision BMI ≤ 3 years (kg/m2)
Yes
37.1 ± 0
1.85
0.12
No
30.9 ± 3.1
Post-revision BMI ≤ 5 years (kg/m2)
Yes
28.5 ± 0.9
− 2.25
0.11
No
32.3 ± 2.2
Regarding the effects of conversion on T2DM, the present data demonstrated a range of remission up to 65–78% during the first 5 years. In Bruzzi’s series, the remission rate for diabetic patients after revisional OAGB/MGB was 85% [24], while another study showed a 100% remission of T2DM after revisional OAGB/MGB compared to 60% remission after revisional RYGB [25]. Debs et al. also reported that ten out of 13 patients had remission or improvement of T2DM after revisional OAGB/MGB [26]. Musella et al. reported a 75% and 50% remission of T2DM after failed primary sleeve gastrectomy and adjustable banding, respectively, as restrictive operations converted to OAGB/MGB [19].
Revisional OAGB/MGB operation also causes improvements in other comorbidities, such as HTN, with remission rates of 58–94% 5 years following the redo surgery. Chiappetta et al. concluded that a 1-year follow-up leads to a greater metabolic improvement after OAGB/MGB following failed LSG compared to RYGB [25]. In the study by Debs et al., HTN was resolved or improved in 19 out of the 23 patients (82%) after 55 months [26]. Similarly, in another study by Jamal et al., out of 19 HTN patients, all had normalized blood pressure 1 year after OAGB/MGB, and no longer need to take any antihypertensive medications or at least decreased their medication intake [30]. Conversely, Musella et al. reported a lower rate (40%) of remission from HTN in their series [19].
In addition to T2DM remission, this analysis found an improvement in the lipid profile. Some articles did not report the DL outcomes after OAGB/MGB as a revisional operation [17, 21, 23, 26, 30]. Nevertheless, a 75% remission rate of DL was reported by Bruzzi et al. [24]. Chiappetta et al. also showed a 25% and 61.5% improvement in DL after revisional RYGB and OAGB/MGB, respectively [25]. Another study revealed a 56% remission of dyslipidemia after revision of failed sleeve gastrectomy or adjustable band to OAGB/MGB [19]. Lipid profile change after primary OAGB/MGB was also reported by Milone et al., and more than 50% of the patients had a normal lipid profile after primary OAGB/MGB [46].
Furthermore, an OAGB/MGB operation also caused improvements in OSA, with average remission rates of 86% in the 5-year follow-up. In the study by Debs et al., HTN was resolved in 27 out of the 33 patients (82%) after 55 months [26]. In the study by Bruzzi et al., no significant differences were found in the remission rates of any obesity-related comorbidity such as OSA, which had occurred in the revisional and primary groups. These authors reported a 50% remission rate for OSA in both groups [24]. Similarly, Piazza et al. found a 66% remission only 6 months after OAGB/MGB following failed adjustable GB [20].
Although there is a clear difference between acid reflux and bile reflux [47], the risk of GERD and/or bile reflux after primary and revisional OAGB/MGB is currently debated in literature [48, 49]. Present meta-analysis showed that conversional OAGB/MGB can lead to GERD improvement in approximately 82% of patients. Only three studies reported de novo GERD and bile reflux (BR) in the patients who had no GERD symptoms before conversional OAGB/MGB [10, 26, 27]. A defective surgical technique could be the reason for reflux after conversional OAGB/MGB, especially due to a short gastric pouch [10, 50, 51] or the presence of undetected and non-repaired hiatal hernia [52].
Redo surgery is often burdened by a higher rate of postoperative complications due to the more complicated surgery procedure; however, even though revisional OAGB/MGB needs skilled and expert surgeons, the intervention itself appears to be more feasible than classic RYGB or other malabsorptive operations. The present review showed that complications such as port site infection, abscess, trocar site hernia, incisional hernia, colonic necrosis, bowel obstruction and ileus, pneumonia, and anastomotic stricture were within the range of primary OAGB/MGB. The first most common complication was leakage, with a rate of 1.6%, which is slightly higher than for the primary procedure, and the second most common complication was bleeding, with a rate of 1.2%, which was comparable to that for primary OAGB/MGB [12, 14, 53‐55]. The rate of hypoalbuminemia was only 0.2% in 1771 patients although most studies report a BPL of 200 cm. It may be under-reported as a major complication in some studies or lesser effect on albumin as a revisional procedure in patient who had an initial bariatric procedure.
Strength and Limitations
It must be considered no RCTs on OAGB/MGB as revisional surgery following restrictive procedures have been published so far. Although a similar paper has recently been published [14], this study is the first systematic review in which a meta-analysis has been developed. Also, conversion surgery data from VBG to OAGB/MGB have been evaluated. Main limitation is surely represented by the retrospective setting of all studies we considered. Again, although recalled in Table 4, it must be noted that definition for weight regain is not univocal in many of the papers we retrieved.
Conclusion
OAGB/MGB as a revisional procedure after failed restrictive bariatric surgery is feasible and effective. Regardless of the BPL length, conversion to OAGB/MGB induces further weight loss after LSG, VGB, and especially LAGB. The rate of remission of classic obesity-related diseases after this procedure is satisfactory, and its postoperative complications are comparable to those of primary OAGB/MGB.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed Consent
Informed consent does not apply.
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One Anastomosis/Mini-Gastric Bypass (OAGB/MGB) as Revisional Surgery Following Primary Restrictive Bariatric Procedures: a Systematic Review and Meta-Analysis
verfasst von
Mohammad Kermansaravi Shahab Shahabi Shahmiri Amir Hossein DavarpanahJazi Rohollah Valizadeh Giovanna Berardi Antonio Vitiello Mario Musella Miguel Carbajo
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