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COPD patients with and without metabolic syndrome: clinical and functional differences

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Abstract

Chronic obstructive pulmonary disease (COPD) and the metabolic syndrome (MetS) are considered public health challenges of the 21st century. The coexistence of MetS in COPD patients and any clinical differences between COPD patients with and without MetS have not been extensively studied. We aimed to describe the clinical characteristics of patients with MetS and COPD. An observational, multicenter study of 375 patients hospitalized for a COPD exacerbation with spirometric confirmation was performed. We measured the components of the MetS and collected comorbidity information using the Charlson index and other conditions. Dyspnea, use of steroids, exacerbations, and hospitalizations were also investigated. The overall prevalence of MetS in COPD patients was 42.9 %, was more frequent in women (59.5 %) than men (40.8 %), p = 0.02, but with no differences in age and smoking history. COPD patients with MetS had greater % predicted FEV1, more dyspnea, and more comorbidity and used more inhaled steroids (all p < 0.05). Diabetes, osteoporosis, coronary artery disease, and heart failure were more frequent in patients with MetS. They had been hospitalized more frequently for any cause but not for COPD. In multivariate analysis, the presence of MetS was independently associated with greater FEV1, inhaled steroids use, osteoporosis, diabetes, and heart failure. MetS is a frequent condition in COPD patients, and it is associated with greater FEV1, more dyspnea, and more comorbidities.

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Authors and Affiliations

  1. Internal Medicine Service, Hospital Royo Villanova, Avda San Gregorio no 30, 50015, Saragossa, Spain

    Jesús Díez-Manglano

  2. Internal Medicine Service, Hospital Tierra de Barros, Almendralejo, Badajoz, Spain

    José Barquero-Romero

  3. Internal Medicine Service, Hospital Universitario Mutua de Terrasa, Terrassa, Barcelona, Spain

    Pedro Almagro

  4. Internal Medicine Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Francisco Javier Cabrera

  5. Internal Medicine Service, Hospital Vega Baja, Orihuela, Alicante, Spain

    Francisco López García

  6. Internal Medicine Service, Hospital de la Axarquia, Vélez-Málaga, Málaga, Spain

    Lorena Montero

  7. Programa de Epidemiología e Investigación Clínica, Fundación Caubet-CIMERA, Centro Internacional de Medicina Respiratoria Avanzada, Baleares, Spain

    Joan Baptiste Soriano

Authors
  1. Jesús Díez-Manglano
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  2. José Barquero-Romero
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  3. Pedro Almagro
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  4. Francisco Javier Cabrera
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  5. Francisco López García
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  6. Lorena Montero
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  7. Joan Baptiste Soriano
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Working Group on COPD; Spanish Society of Internal Medicine

Corresponding author

Correspondence to Jesús Díez-Manglano.

Appendix

Appendix

Investigators of the ECCO Study, Working Group on COPD of the Spanish Society of Internal Medicine: Santiago Mola Caballero de Rodas, Francisco López García, Jose Antonio Carratalá Torregrosa, Gemma Penadés Cervera, Juan Custardoy Olavarrieta (Hospital Vega Baja-Orihuela, Alicante); Alberto Muela Molinero, Juan Carlos Borrego Galán, (Hospital General de León); Rocío Llanos Llanos, María del Carmen García Orenes (Hospital Morales Meseguer, Murcia); Juan Manuel Quiroga Iturralde, Gabriel Zubillaga Garmendia, Elena Zubillaga Azpiroz (Hospital de Donostia, San Sebastián); Mario Fernández Ruiz (Hospital General Universitario 12 de Octubre, Madrid); Jesús Recio Iglesias (Hospital General Universitario Vall d’Hebron, Barcelona); María del Carmen Martínez Velasco (Hospital San Juan de Dios, Pamplona); María Paz Pérez Gutiérrez (Hospital Clínico Universitario, Valladolid); Francisco Javier Cabrera Aguilar, Pablo Ryan Murua (Hospital General Universitario Gregorio Marañón, Madrid), Juan Antonio Oriz Minuesa, Manuel Montero Pérez-Barquero (Hospital General Universitario Reina Sofía, Córdoba); Jesús Castiella Herrero, Francisco José Sanjuan Portugal (Fundación Hospital Calahorra, La Rioja); Juan Lucio Ramos Salado, José Barquero Romero (Complejo Universitario Infanta Cristina, Badajoz); Fernando Javier Sánchez Lora (Hospital de Antequera, Málaga); Angel Hortal Tavira (Hospital Virgen de Las Nieves, Granada); Jerónimo Nieto López Guerrero (Hospital de Cantoblanco, Madrid); María Cruz Almendros Rivas (Hospital de Palamos, Madrid); Fernando de la Iglesia Martinez (Hospital Juan Canalejo, A Coruña); Carlos Dueñas Gutiérrez (Hospital General Yagüe, Burgos); José Luis Lozano Polo (Hospital General Marqués de Valdecilla, Santander); Dámaso Escribano Sevillano (Hospital de Jove, Gijón); Luis Quiroga Prado (Hospital de León); Carmen Mella Pérez (Hospital Vilagarcia de Arousa, Pontevedra); Ramón Cigüenza Gabriel (Hospital Clínico San Carlos, Madrid); José Portillo Sánchez (Hospital General de Ciudad Real); Ramon Boixeda i Viu (Hospital de Mataró, Barcelona); Lorena Montero Rivas, Carlos M San Román Terán (Hospital Comarcal Axarquía. Vélez Málaga, Málaga); Joan Carles Trullas Vila (Hospital San Jaume Olot, Gerona); Bernardino Roca Villanueva (Hospital General de Castellón); Julio Montes Santiago (Hospital Do Meixoeiro, Vigo); José Manuel Varela (Hospital Virgen del Rocío, Sevilla); David Morchón, Juan Carlos Martín Escudero (Hospital Universitario Rio Hortega, Valladolid); Jesús Díez Manglano (Hospital Royo Villanova, Zaragoza); Elena Güell i Farré (Consorci Sanitari Integral, Barcelona); Olga Araújo Loperena (Hospital Xarxa Tecla, Tarragona); Nuria Galofré Alvaro (Hospital de Badalona); Beatriz Sobrino Diaz (Hospital General Universitario Carlos Haya, Málaga); Ana Belen Mecina Gutiérrez, María del Carmen Romero Pérez (Hospital de Leganés, Madrid); Patricia Crecente Otero, Laura Madrigal Cortés, Rubén Díez Bandera, Verónica Alvarez Alamo (Hospital Clínico Universitario, Salamanca); PedroAlmagro Mena (Hospital Mutua de Terrassa, Barcelona); Pablo Espejo Salamanca (Fundación Hospital de Manacor, Mallorca); Vicente Giner Galvan (Hospital de Alcoy, Alicante); Rafael Castillo Rubio (Hospital La Malvarrosa, Valencia).

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Díez-Manglano, J., Barquero-Romero, J., Almagro, P. et al. COPD patients with and without metabolic syndrome: clinical and functional differences. Intern Emerg Med 9, 419–425 (2014). https://doi.org/10.1007/s11739-013-0945-7

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