Statement of significance
Introduction
Methods
Study design
Percutaneous coronary intervention and medical management of STEMI
Polysomnography
ECG acquisition and analysis
Cardiovascular magnetic resonance acquisition and analysis
Statistical analysis
Results
Patient characteristics
No SDB (n = 17) | SDB (n = 18) | p-value | |
---|---|---|---|
Age, years | 53 ± 10 | 56 ± 9 | 0.470 |
Body mass index, kg/m2 | 27 ± 3 | 29 ± 4 | 0.281 |
Male gender, n (%) | 13 (77) | 16 (89) | 0.330 |
Heart rate, beats/minute | 73 ± 14 | 80 ± 18 | 0.223 |
Systolic blood pressure, mm Hg | 121 ± 26 | 131 ± 26 | 0.272 |
Diastolic blood pressure, mm Hg | 77 ± 14 | 78 ± 14 | 0.833 |
Hypertension, n (%) | 10 (59) | 9 (50) | 0.600 |
Current smoker, n (%) | 11 (65) | 8 (44) | 0.229 |
Diabetes mellitus, n (%) | 1 (6) | 3 (17) | 0.316 |
Hypercholesterolemia, n (%) | 5 (29) | 2 (11) | 0.176 |
Symptom-to-balloon time, h (IQR) | 4.5 (2.95–7.13) | 3.84 (2.79–9.86) | 0.869 |
Non-LAD infarction, n (%) | 9 (53) | 8 (44) | 0.615 |
TIMI flow before PCI, n (%) | – | – | 0.258 |
Grade 0 | 13 (76) | 16 (89) | – |
Grade 1 | 3 (18) | 1 (6) | – |
TIMI flow post PCI, n (%) | – | – | 0.316 |
Grade 2 | 1 (6) | 3 (17) | – |
Grade 3 | 16 (94) | 15 (83) | – |
Thrombus aspiration, n (%) | 9 (53) | 11 (61) | 0.625 |
Glycoprotein IIb/IIIa inhibitor, n (%) | 13 (77) | 15 (83) | 0.612 |
CK at admission, U/L (IQR) | 247 (170–1071) | 394 (138–2050) | 0.869 |
Apnea–hypopnea index, 1/h | 6 ± 4 | 33 ± 15 | <0.001 |
Mean oxygen saturation, % | 93 ± 3 | 93 ± 1 | 0.634 |
Minimum oxygen saturation, % | 87 ± 4 | 84 ± 5 | 0.130 |
Total sleep time, min | 392 ± 87 | 327 ± 74 | 0.216 |
Rapid eye movement sleep, min | 17 ± 7 | 15 ± 6 | 0.389 |
ST deviation and relative resolution of ST deviation
Microvascular obstruction
NT-proBNP
Predictors of ST deviation and MVO
Predictors of endpoint | ST deviation 0–24 h post PCI (µV) | ST deviation >24 h post PCI (µV) | Microvascular obstruction (%) | |||
---|---|---|---|---|---|---|
B (95% CI) |
p
| B (95% CI) |
p
| B (95% CI) |
p
| |
Symptom-to-balloon time | 2.00 [0.28; 3.71] |
0.025
| 1.90 [0.35; 3.46] |
0.019
| 0.05 [−0.14; 0.25] | 0.586 |
Anterior infarction | 25.44 [−3.83; 54.71] | 0.086 | 45.92 [19.43; 72.42] |
0.001
| −0.02 [−3.14; 3.11] | 0.992 |
TIMI flow pre PCIa | −25.22 [−70.41; 19.98] | 0.261 | −55.49 [−96.40; −14.58] |
0.010
| −3.01 [−7.36; 1.33] | 0.165 |
TIMI flow post PCIb | −32.82 [−85.97; 20.33] | 0.215 | −57.87 [−105.98; −9.76] |
0.020
| −5.09 [−9.85; −0.33] |
0.037
|
Current smoking | 21.35 [−9.53; 52.23] | 0.167 | 39.11 [11.16; 67.05] |
0.008
| 1.43 [−1.68; 4.55] | 0.351 |
ST deviation pre PCI (µV) | 0.27 [0.07; 0.48] |
0.012
| 0.16 [−0.03; 0.34] | 0.097 | Not included | – |
AHI/h | 0.45 [−0.32; 1.22] | 0.240 | 0.82 [0.12; 1.51] |
0.024
| 0.08 [0.01; 0.16] |
0.036
|
Model summaryc | R2 = 0.45; F = 2.97 | R2 = 0.59; F = 5.20 | R² = 0.35; F = 2.04 |