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Current Allergy and Asthma Reports

Erschienen in:

01.12.2012 | AUTOIMMUNITY (TK TARRANT, SECTION EDITOR)

Cellular Targeting in Autoimmunity

verfasst von: Jennifer L. Rogers, Donald S. Serafin, Roman G. Timoshchenko, Teresa K. Tarrant

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2012

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Abstract

Many biologic agents that were first approved for the treatment of malignancies are now being actively investigated and used in a variety of autoimmune diseases such as rheumatoid arthritis (RA), antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, systemic lupus erythematosus (SLE), and Sjogren’s syndrome. The relatively recent advance of selective immune targeting has significantly changed the management of autoimmune disorders and in part can be attributed to the progress made in understanding effector cell function and their signaling pathways. In this review, we will discuss the recent FDA-approved biologic therapies that directly target immune cells as well as the most promising investigational drugs affecting immune cell function and signaling for the treatment of autoimmune disease.

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Titel: Cellular Targeting in Autoimmunity
verfasst von: Jennifer L. Rogers
Donald S. Serafin
Roman G. Timoshchenko
Teresa K. Tarrant
Publikationsdatum: 01.12.2012
Verlag: Current Science Inc.
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 6/2012
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-012-0307-y

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