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Current Allergy and Asthma Reports

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01.02.2014 | RHINITIS (JJ OPPENHEIMER AND J CORREN, SECTION EDITORS)

Preventing Progression of Allergic Rhinitis to Asthma

verfasst von: Jaymin B. Morjaria, Massimo Caruso, Emma Rosalia, Cristina Russo, Riccardo Polosa

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 2/2014

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Abstract

The prevalence of allergic rhinitis (AR) is on the increase and this condition is frequently associated with asthma, thus leading to the concept that these two conditions are different aspects of the same disease. There is now accumulating evidence that AR often precedes the onset of asthmatic symptoms. This notion has important implications, not only for the diagnosis and management of these common allergic conditions but also for the potential progression of disease. Very little is known about the risk factors responsible for the progression of AR to asthma; current treatment options can control symptoms but do not prevent or cure the disease. However, there are recent data supporting the notion that it is possible to prevent new asthma cases by modifying the immune response and clinical outcome with allergen immunotherapy. This review article evaluates the impact of AR on the development of asthma, examines putative predictors for the progression of AR to asthma, and reviews recent, promising literature suggesting that early treatment of allergic individuals with immunotherapy may aid in asthma prevention.

Togias A. Mechanisms of nose-lung interaction. Allergy. 1999;54 Suppl 57:94–105.PubMedCrossRef

Passalacqua G, Ciprandi G, Canonica GW. The nose-lung interaction in allergic rhinitis and asthma: united airways disease. Curr Opin Allergy Clin Immunol. 2001;1:7–13.PubMed

Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108:S147–334.PubMedCrossRef

Bousquet J, Vignola AM, Demoly P. Links between rhinitis and asthma. Allergy. 2003;58:691–706.PubMedCrossRef

Lin J, Su N, Liu G, Yin K, Zhou X, Shen H, Chen P, Chen R, Liu C, Wu C, Zhao J, Lin Y. The impact of concomitant allergic rhinitis on asthma control: A cross-sectional nationwide survey in China. J Asthma. 2013. (In press).

Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012;67(1):91–8.PubMedCrossRef

Pawankar R, Zernotti ME. Rhinosinusitis in children and asthma severity. Curr Opin Allergy Clin Immunol. 2009;9(2):151–3.PubMed

Simons FE. Allergic rhinobronchitis: the asthma-allergic rhinitis link. J Allergy Clin Immunol. 1999;104:534–40.PubMedCrossRef

Taramarcaz P, Gibson PG. The effectiveness of intranasal corticosteroids in combined allergic rhinitis and asthma syndrome. Clin Exp Allergy. 2004;34(12):1883–9.PubMedCrossRef

10.

Bonay M, Neukirch C, Grandsaigne M, Lecon-Malas V, Ravaud P, Dehoux M, et al. Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitis. Allergy. 2006;61:111–8.PubMedCrossRef

11.

Braunstahl GJ, Kleinjan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med. 2000;161:2051–7.PubMedCrossRef

12.••

Ciprandi G, Signori A, Tosca MA, Cirillo I. Spirometric abnormalities in patients with allergic rhinitis: Indicator of an "asthma march"? Am J Rhinol Allergy. 2011;25:e181–5. Large study showing frequent abnormalities in spirometric parameters (including reversibility with beta2-agonists) in 1,605 adults with AR. This study lends support to the view of a close link between upper and lower airways.PubMedCrossRef

13.

Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63 Suppl 86:8–160.PubMedCrossRef

14.

Linneberg A, Henrik Nielsen N, Frolund L, Madsen F, Dirksen A, Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy. 2002;57:1048–52.PubMedCrossRef

15.

Cirillo I, Ricciardolo FL, Medusei G, Signori A, Ciprandi G. Exhaled nitric oxide may predict bronchial hyperreactivity in patients with allergic rhinitis. Int Arch Allergy Immunol. 2013;160(3):322–8.PubMedCrossRef

16.

Nickel R, Lau S, Niggemann B, Gruber C, von Mutius E, Illi S, et al. Messages from the German Multicentre Allergy Study. Pediatr Allergy Immunol. 2002;13 Suppl 15:7–10.PubMedCrossRef

17.

Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 2003;112:S118–27.PubMedCrossRef

18.

Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–43.PubMedCrossRef

19.

Izquierdo-Domínguez A, Valero AL, Mullol J. Comparative analysis of allergic rhinitis in children and adults. Curr Allergy Asthma Rep. 2013;13:142–51.PubMedCrossRef

20.

Leynaert B, Neukirch F, Demoly P, Bousquet J. Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol. 2000;106:S201–5.PubMedCrossRef

21.

Ramsdale EH, Morris MM, Roberts RS, Hargreave FE. Asymptomatic bronchial hyperresponsiveness in rhinitis. J Allergy Clin Immunol. 1985;75:573–7.PubMedCrossRef

22.

Crimi N, Palermo F, Oliveri R, Vancheri C, Distefano SM, Palermo B, et al. Influence of asthmatic and rhinitic symptomatology duration on bronchial responsiveness to histamine. Int J Tissue React. 1987;9:515–20.PubMed

23.

Djukanovic R, Lai CK, Wilson JW, Britten KM, Wilson SJ, Roche WR, et al. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J. 1992;5:538–44.PubMed

24.

Polosa R, Ciamarra I, Mangano G, Prosperini G, Pistorio MP, Vancheri C, et al. Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis. Eur Respir J. 2000;15:30–5.PubMedCrossRef

25.

Canonica GW, Compalati E. Minimal persistent inflammation in allergic rhinitis: implications for current treatment strategies. Clin Exp Immunol. 2009;158(3):260–71.PubMedCentralPubMedCrossRef

26.

Braman SS, Barrows AA, DeCotiis BA, Settipane GA, Corrao WM. Airway hyperresponsiveness in allergic rhinitis. A risk factor for asthma. Chest. 1987;91:671–4.PubMedCrossRef

27.

Sparrow D, O’Connor G, Colton T, Barry CL, Weiss ST. The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. Am Rev Respir Dis. 1987;135:1255–60.PubMed

28.

Hopp RJ, Townley RG, Biven RE, Bewtra AK, Nair NM. The presence of airway reactivity before the development of asthma. Am Rev Respir Dis. 1990;141:2–8.PubMedCrossRef

29.

Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol. 2002;109:251–6.PubMedCrossRef

30.

Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De Marco E, et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2004;114:851–7.PubMedCrossRef

31.

Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Host A, et al. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006;61:855–9.PubMedCrossRef

32.

Marogna M, Tomassetti D, Bernasconi A, Colombo F, Massolo A, Businco AD, et al. Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study. Ann Allergy Asthma Immunol. 2008;101:206–11.PubMedCrossRef

33.

Burgess JA, Walters EH, Byrnes GB, Matheson MC, Jenkins MA, Wharton CL, et al. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. J Allergy Clin Immunol. 2007;120:863–9.PubMedCrossRef

34.

Settipane RJ, Hagy GW, Settipane GA. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc. 1994;15:21–5.PubMedCrossRef

35.

Shaaban R, Zureik M, Soussan D, Neukirch C, Heinrich J, Sunyer J, et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet. 2008;372:1049–57.PubMedCrossRef

36.

Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol. 2002;109:419–25.PubMedCrossRef

37.

Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol. 2004;113:86–93.PubMedCrossRef

38.

Polosa R, Al-Delaimy WK, Russo C, Piccillo G, Sarva M. Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study. Respir Res. 2005;6:153.PubMedCentralPubMedCrossRef

39.••

Martin PE, Matheson MC, Gurrin L, Burgess JA, Osborne N, Lowe AJ, et al. Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: a prospective cohort study over 4 decades. J Allergy Clin Immunol. 2011;127:1473–9 e1. This prospective cohort study with an extended follow up of over 4 decades provides convincing evidence for the progression from childhood eczema to rhinitis and atopic asthma.PubMedCrossRef

40.

Platts-Mills TA, Wheatley LM. The role of allergy and atopy in asthma. Curr Opin Pulm Med. 1996;2:29–34.PubMed

41.

Platts-Mills TAE, de Weck AL. Dust mite allergens and asthma ― a worldwide problem. J Allergy Clin Immunol. 1989;83:416–27.CrossRef

42.

Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990;323:502–7.PubMedCrossRef

43.

Venn A, Lewis S, Cooper M, Hill J, Britton J. Questionnaire study of effect of sex and age on the prevalence of wheeze and asthma in adolescence. BMJ. 1998;316:1945–6.PubMedCrossRef

44.

Ehrlich RI, Du Toit D, Jordaan E, Zwarenstein M, Potter P, Volmink JA, et al. Risk factors for childhood asthma and wheezing. Importance of maternal and household smoking. Am J Respir Crit Care Med. 1996;154:681–8.PubMedCrossRef

45.

Lux AL, Henderson AJ, Pocock SJ. Wheeze associated with prenatal tobacco smoke exposure: a prospective, longitudinal study. ALSPAC Study Team. Arch Dis Child. 2000;83:307–12.PubMedCrossRef

46.

Mannino DM, Moorman JE, Kingsley B, Rose D, Repace J. Health effects related to environmental tobacco smoke exposure in children in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med. 2001;155:36–41.PubMedCrossRef

47.

Polosa R, Knoke JD, Russo C, Piccillo G, Caponnetto P, Sarva M, et al. Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis. J Allergy Clin Immunol. 2008;121:1428–34.PubMedCrossRef

48.

Polosa R, Caruso M, Oliveri Conti G, Ferrante M. 2013 Intern Emerg Med. 2013. (In press).

49.

Diaz-Sanchez D, Rumold R, Gong Jr H. Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings. J Allergy Clin Immunol. 2006;118:441–6.PubMedCrossRef

50.

Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med. 2001;164:S1–5.PubMedCrossRef

51.

Piccillo G, Caponnetto P, Barton S, Russo C, Origlio A, Bonaccorsi A, et al. Changes in airway hyperresponsiveness following smoking cessation: comparisons between Mch and AMP. Respir Med. 2008;102:256–65.PubMedCrossRef

52.

Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. Tilles SA; Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy. Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122(2 Suppl):S1–84.PubMedCrossRef

53.

Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy. 2007;62:943–8.PubMedCrossRef

54.

Polosa R, Li Gotti F, Mangano G, Paolino G, Mastruzzo C, Vancheri C, et al. Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis. Allergy. 2004;59:1224–8.PubMedCrossRef

55.

Milani M, Pecora S, Burastero S. Observational study of sublingual specific immunotherapy in persistent and intermittent allergic rhinitis: the EFESO trial. Curr Med Res Opin. 2008;24:2719–24.PubMedCrossRef

56.

Till SJ, Francis JN, Nouri-Aria K, Durham SR. Mechanisms of immunotherapy. J Allergy Clin Immunol. 2004;113:1025–34.PubMedCrossRef

57.

Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006;6:761–71.PubMedCrossRef

58.

Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol. 2008;8(3):218–30.PubMedCrossRef

59.••

Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol. 2013;131(5):1288–96. A comprehensive consensus report on the mechanisms of allergen IT and its use in clinical practice, as well as unmet needs and ongoing developments.PubMedCrossRef

60.•

Novak N, Mete N, Bussmann C, Maintz L, Bieber T, Akdis M, et al. Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2. J Allergy Clin Immunol. 2012;130(5):1153–8. Fascinating work addressing very early mechanisms of allergen tolerance induced by specific immunotherapy on effector FceR1-bearing cells.PubMedCrossRef

61.

Cady CT, Powell MS, Harbeck RJ, Giclas PC, Murphy JR, Katial RK, et al. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett. 2010;130(1–2):57–65.PubMedCentralPubMedCrossRef

62.

Polosa R. Can immunotherapy prevent progression to asthma in allergic individuals? J Allergy Clin Immunol. 2002;110:672–3.PubMedCrossRef

63.

Baena-Cagnani CE, Larenas-Linnemann D, Teijeiro A, Canonica GW, Passalacqua G. Will Sublingual Immunotherapy Offer Benefit for Asthma? Curr Allergy Asthma Rep. 2013 (in press).

64.

Purello-D’Ambrosio F, Gangemi S, Merendino RA, Isola S, Puccinelli P, Parmiani S, et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin Exp Allergy. 2001;31:1295–302.PubMedCrossRef

65.

Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol. 1997;99:450–3.PubMedCrossRef

66.

Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy. 2001;31:1392–7.PubMedCrossRef

67.

Inal A, Altintas DU, Yilmaz M, Karakoc GB, Kendirli SG, Sertdemir Y. Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/or asthma monosensitized to house dust mite. J Investig Allergol Clin Immunol. 2007;17:85–91.PubMed

68.

http://clinicaltrials.gov/ct2/show/NCT01061203.

69.

http://clinicaltrials.gov/ct2/show/NCT00346398.

70.

Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2003:CD001186.

71.

Penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A, et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2008;133:599–609.PubMedCrossRef

72.

Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 2006;354:1985–97.PubMedCrossRef

73.

Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med. 2006;354:1998–2005.PubMedCrossRef

74.

Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet. 2006;368:754–62.PubMedCrossRef

Titel: Preventing Progression of Allergic Rhinitis to Asthma
verfasst von: Jaymin B. Morjaria
Massimo Caruso
Emma Rosalia
Cristina Russo
Riccardo Polosa
Publikationsdatum: 01.02.2014
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 2/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-013-0412-6

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