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01.07.2014 | IMMUNOTHERAPY AND IMMUNOMODULATORS (L COX, SECTION EDITOR)

Venom Immunotherapy: an Updated Review

verfasst von: Darío Antolín-Amérigo, Carmen Moreno Aguilar, Arantza Vega, Melchor Alvarez-Mon

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2014

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Abstract

Venom immunotherapy (VIT) is the most effective form of specific immunotherapy to date. Hitherto, several relevant queries remain unanswered, namely optimal doses, duration, and means of assessment. Important progress has been lately made in terms of diagnosis by means of component-resolved diagnosis. Moreover, basophil activation test results in patients with negative serum immunoglobulin E (IgE) and skin prick test confer this technique a promising future, although these outcomes shall be considered with caution. This review aims to unravel the important advances made on diagnosis, management, and prognosis and also focuses on several undetermined aspects of VIT.
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Zurück zum Zitat González-de-Olano D, Alvarez-Twose I, Vega A, Orfao A, Escribano L. Venom immunotherapy in patients with mastocytosis and hymenoptera venom anaphylaxis. Immunotherapy. 2011;3(5):637–51. Severe adverse reactions tohymenoptera stings or venom immunotherapy have been associated with increased serum baseline tryptase; however, presence of clonal MC has not been ruled out in most reports and thus both SM and clonal MC activation syndrome might be underdiagnosed in such patients. A new clinical score for such patients is advised.PubMedCrossRef González-de-Olano D, Alvarez-Twose I, Vega A, Orfao A, Escribano L. Venom immunotherapy in patients with mastocytosis and hymenoptera venom anaphylaxis. Immunotherapy. 2011;3(5):637–51. Severe adverse reactions tohymenoptera stings or venom immunotherapy have been associated with increased serum baseline tryptase; however, presence of clonal MC has not been ruled out in most reports and thus both SM and clonal MC activation syndrome might be underdiagnosed in such patients. A new clinical score for such patients is advised.PubMedCrossRef
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Zurück zum Zitat Alvarez-Twose I, Zanotti R, González-de-Olano D, Bonadonna P, Vega A, Matito A et al. Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM. J Allergy Clin Immunol. 2013 Aug 3. Indolent systemic mastocytosis (ISM) without skin lesions (ISMs − ) patients with anaphylaxis triggered exclusively by insects display clinical and laboratory features significantly different from other ISM cases with cutaneous lesions, such as male predominance, lower serum baseline tryptase levels, and KIT mutation more frequently restricted to bone marrow (BM) mast cells (MCs). Alvarez-Twose I, Zanotti R, González-de-Olano D, Bonadonna P, Vega A, Matito A et al. Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM. J Allergy Clin Immunol. 2013 Aug 3. Indolent systemic mastocytosis (ISM) without skin lesions (ISMs ) patients with anaphylaxis triggered exclusively by insects display clinical and laboratory features significantly different from other ISM cases with cutaneous lesions, such as male predominance, lower serum baseline tryptase levels, and KIT mutation more frequently restricted to bone marrow (BM) mast cells (MCs).
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Metadaten
Titel
Venom Immunotherapy: an Updated Review
verfasst von
Darío Antolín-Amérigo
Carmen Moreno Aguilar
Arantza Vega
Melchor Alvarez-Mon
Publikationsdatum
01.07.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 7/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0449-1

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