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Current Allergy and Asthma Reports

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01.04.2015 | Rhinitis (JJ Oppenheimer and J Corren (Section Editors)

Controlled Allergen Challenge Facilities and Their Unique Contributions to Allergic Rhinitis Research

verfasst von: Michelle L. North, Mena Soliman, Terry Walker, Lisa M. Steacy, Anne K. Ellis

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 4/2015

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Abstract

The aim of this study is to review advances in basic and clinical allergic rhinitis (AR) research over the past decade that have been conducted using controlled allergen challenge facility (CACF) models of allergen challenge. Databases, including PubMed, Medline, and Web of Science were searched for articles employing an ambient pollen exposure in a controlled facility to study AR, published between 2004 and the present date, using the terms as follows: CACF, Environmental Exposure Unit (EEU), Vienna Challenge Chamber (VCC), Fraunhofer Institute Environmental Challenge Chamber, Atlanta Allergen Exposure Unit, Biogenics Research Chamber, Allergen BioCube, Chiba and Osaka Environmental Challenge Chamber, exposure unit, challenge chamber, or environmental exposure chamber. Articles were then selected for relevance to the goals of the present review, including important contributions toward clinical and/or basic science allergy research. CACFs offer sensitive, specific, and reproducible methodology for allergen challenge. They have been employed since the 1980s and offer distinct advantages over traditional in-season multicentre trials when evaluating new treatments for AR. They have provided clinically applicable efficacy and pharmacologic information about important allergy medications, including antihistamines, decongestants, antileukotrienes, immunotherapies, and nasal steroids. CACF models have also contributed to basic science and novel/experimental therapy research. To date, no direct studies have been conducted comparing outcomes from one CACF to another. Over the past decade, CACF models have played an essential role in investigating the pathophysiology of AR and evaluating new therapies. The future opportunities for this model continue to expand.

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Titel: Controlled Allergen Challenge Facilities and Their Unique Contributions to Allergic Rhinitis Research
verfasst von: Michelle L. North
Mena Soliman
Terry Walker
Lisa M. Steacy
Anne K. Ellis
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 4/2015
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-015-0514-4

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Controlled Allergen Challenge Facilities and Their Unique Contributions to Allergic Rhinitis Research

Abstract

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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