nach oben

Current Allergy and Asthma Reports

Erschienen in:

01.11.2016 | Allergies and the Environment (M Hernandez, Section Editor)

Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies

verfasst von: Gayan Bowatte, Caroline J. Lodge, Jennifer L. Perret, Melanie C. Matheson, Shyamali C. Dharmage

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 12/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

The purpose of this review is to summarize the evidence from recently published original studies investigating how glutathione S-transferase (GST) gene polymorphisms modify the impact of air pollution on asthma, allergic diseases, and lung function.

Recent Findings

Current studies in epidemiological and controlled human experiments found evidence to suggest that GSTs modify the impact of air pollution exposure on respiratory diseases and allergies. Of the nine articles included in this review, all except one identified at least one significant interaction with at least one of glutathione S-transferase pi 1 (GSTP1), glutathione S-transferase mu 1 (GSTM1), or glutathione S-transferase theta 1 (GSTT1) genes and air pollution exposure. The findings of these studies, however, are markedly different. This difference can be partially explained by regional variation in the exposure levels and oxidative potential of different pollutants and by other interactions involving a number of unaccounted environment exposures and multiple genes.

Summary

Although there is evidence of an interaction between GST genes and air pollution exposure for the risk of respiratory disease and allergies, results are not concordant. Further investigations are needed to explore the reasons behind the discordancy.

Xing Y-F, Xu Y-H, Shi M-H, Lian Y-X. The impact of PM2.5 on the human respiratory system. J Thorac Dis. 2016;8(1):E69–74. doi:10.3978/j.issn.2072-1439.2016.01.19.PubMedPubMedCentral

Last JA, Sun WM, Witschi H. Ozone, NO, and NO2: oxidant air pollutants and more. Environ Health Perspect. 1994;102 Suppl 10:179–84.CrossRefPubMedPubMedCentral

Nawrot TS, Kuenzli N, Sunyer J, Shi T, Moreno T, Viana M, et al. Oxidative properties of ambient PM2.5 and elemental composition: heterogeneous associations in 19 European cities. Atmos Environ. 2009;43(30):4595–602. doi:10.1016/j.atmosenv.2009.06.010.

Velsor LW, Postlethwait EM. NO2-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants. Am J Physiol. 1997;273(6 Pt 1):L1265–75.PubMed

•• Carlsten C, Blomberg A, Pui M, Sandstrom T, Wong SW, Alexis N, et al. Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study. Thorax. 2016;71(1):35–44. doi:10.1136/thoraxjnl-2015-207399. This controlled human exposure study demonstrated that exposure to diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals with GSTT1 null polymorphism. CrossRefPubMed

Olivieri D, Scoditti E. Impact of environmental factors on lung defences. Eur Respir Rev. 2005;14(95):51–6.CrossRef

Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet. 2004;363(9403):119–25. doi:10.1016/S0140-6736(03)15262-2.CrossRefPubMed

Chen E, Schreier HM, Strunk RC, Brauer M. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect. 2008;116(7):970–5. doi:10.1289/ehp.11076.CrossRefPubMedPubMedCentral

Gordian ME, Haneuse S, Wakefield J. An investigation of the association between traffic exposure and the diagnosis of asthma in children. J Expo Sci Environ Epidemiol. 2006;16(1):49–55. doi:10.1038/sj.jea.7500436.CrossRefPubMed

10.

Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Del Rio-Navarro BE, Ruiz-Navarro MX, et al. Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone. Clin Exp Immunol. 2004;138(2):317–22. doi:10.1111/j.1365-2249.2004.02606.x.CrossRefPubMedPubMedCentral

11.

Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med. 2000;28(3):463–99. doi:10.1016/S0891-5849(99)00242-7.

12.

Weiss ST. Lung function and airway diseases. Nat Genet. 2010;42(1):14–6.CrossRefPubMed

13.

Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-S-transferase family of enzymes. Mutat Res. 2001;482(1–2):21–6. doi:10.1016/S0027-5107(01)00206-8.

14.

Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000;61(3):154–66. doi:10.1159/000028396.

15.

Piacentini S, Polimanti R, Simonelli I, Donno S, Pasqualetti P, Manfellotto D, et al. Glutathione S-transferase polymorphisms, asthma susceptibility and confounding variables: a meta-analysis. Mol Biol Rep. 2013;40(4):3299–313. doi:10.1007/s11033-012-2405-2.CrossRefPubMed

16.

Romieu I, Moreno-Macias H, London SJ. Gene by environment interaction and ambient air pollution. Proc Am Thorac Soc. 2010;7(2):116–22. doi:10.1513/pats.200909-097RM.CrossRefPubMedPubMedCentral

17.

Holloway JW, Savarimuthu Francis S, Fong KM, Yang IA. Genomics and the respiratory effects of air pollution exposure. Respirology. 2012;17(4):590–600. doi:10.1111/j.1440-1843.2012.02164.x.CrossRefPubMed

18.

Hosgood Iii HD, Berndt SI, Lan Q. GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis. Mutat Res. 2007;636(1–3):134–43. doi:10.1016/j.mrrev.2007.02.002.

19.

•• Minelli C, Wei I, Sagoo G, Jarvis D, Shaheen S, Burney P. Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review. Am J Epidemiol. 2011;173(6):603–20. doi:10.1093/aje/kwq403. Systematic review that synthesized evidence based on literature published until 2009 related to interactions of oxidative stress gene polymorphisms on air pollution exposure and airway diseases.CrossRefPubMed

20.

Kellen E, Hemelt M, Broberg K, Golka K, Kristensen VN, Hung RJ, et al. Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review. Am J Epidemiol. 2007;165(11):1221–30. doi:10.1093/aje/kwm003.CrossRefPubMed

21.

•• Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SLJ, et al. HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM₁₀ reduction. Eur Respir J. 2009;35(3):505–14. doi:10.1183/09031936.000443-2009. Using data from a longitudinal cohort, this study demonstrated the effects of reduced PM ₁₀ over 11 years on lung function change in relation to GST polymorphisms.

22.

Fuertes E, Brauer M, MacIntyre E, Bauer M, Bellander T, von Berg A, et al. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. J Allergy Clin Immunol. 2013;132(2):342-52.e2. doi:10.1016/j.jaci.2013.03.007.CrossRefPubMed

23.

•• MacIntyre EA, Brauer M, Melen E, Bauer CP, Bauer M, Berdel D, et al. GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. Environ Health Perspect. 2014;122(4):418–24. doi:10.1289/ehp.1307459. Combining six birth cohort studies and using advanced air pollution modeling, this study demonstrated how early life exposure to air pollutants is modified by GST polymorphisms. PubMedPubMedCentral

24.

Hwang B-F, Young L-H, Tsai C-H, Tung K-Y, Wang P-C, Su M-W, et al. Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms. PLoS One. 2013;8(1):e52715. doi:10.1371/journal.pone.0052715.CrossRefPubMedPubMedCentral

25.

• Su MW, Tsai CH, Tung KY, Hwang BF, Liang PH, Chiang BL, et al. GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma. Allergy. 2013;68(12):1614–7. doi:10.1111/all.12298. This study reported the effects of differential exposure levels of PM ₁₀ on childhood asthma in children with GSTP1 polymorphism.

26.

Bowatte G, Lodge CJ, Knibbs LD, Lowe AJ, Erbas B, Dennekamp M, et al. Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age. J Allergy Clin Immunol. 2016. doi:10.1016/j.jaci.2016.05.008.PubMed

27.

Chen B-Y, Chen C-H, Chuang Y-C, Kim H, Honda Y, Chiang H-C, et al. Schoolchildren’s antioxidation genotypes are susceptible factors for reduced lung function and airway inflammation caused by air pollution. Environ Res. 2016;149:145–50. doi:10.1016/j.envres.2016.05.007.CrossRefPubMed

28.

Reddy P, Naidoo RN, Robins TG, Mentz G, Li H, London SJ, et al. GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children. Am J Ind Med. 2012;55(12):1078–86. doi:10.1002/ajim.22012.CrossRefPubMedPubMedCentral

29.

• Bowatte G, Lodge CJ, Lowe AJ, Erbas B, Dennekamp M, Marks GB, et al. Do variants in GSTs modify the association between traffic air pollution and asthma in adolescence? Int J Mol Sci. 2016;17(4):485. doi:10.3390/ijms17040485. First epidemiological study to report the significant effects of GSTT1 polymorphisms for the association of air pollution exposure and asthma/wheeze.CrossRefPubMedPubMedCentral

30.

MacIntyre EA, Carlsten C, MacNutt M, Fuertes E, Melen E, Tiesler CMT, et al. Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution’s impact on childhood asthma. Eur J Epidemiol. 2013;28(7):597–606. doi:10.1007/s10654-013-9828-5.CrossRefPubMed

31.

Mainwaring GW, Williams SM, Foster JR, Tugwood J, Green T. The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem J. 1996;318(Pt 1):297–303.CrossRefPubMedPubMedCentral

32.

Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P, et al. Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Am J Epidemiol. 2006;164(11):1027–42. doi:10.1093/aje/kwj321.CrossRefPubMed

33.

Yang F, Xiong J, Jia X-E, Gu Z-H, Shi J-Y, Zhao Y, et al. GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression. PLoS One. 2014;9(2):e89302. doi:10.1371/journal.pone.0089302.CrossRefPubMedPubMedCentral

34.

Zhang X, Hirota JA, Yang C, Carlsten C. Effect of GST variants on lung function following diesel exhaust and allergen co-exposure in a controlled human crossover study. Free Radic Biol Med. 2016;96:385–91. doi:10.1016/j.freeradbiomed.2016.04.202.CrossRefPubMed

35.

Madden MC, Stevens T, Case M, Schmitt M, Diaz-Sanchez D, Bassett M, et al. Diesel exhaust modulates ozone-induced lung function decrements in healthy human volunteers. Part Fibre Toxicol. 2014;11(1):1–10. doi:10.1186/s12989-014-0037-5.CrossRef

36.

Calderón-Garcidueñas L, Rodríguez-Alcaraz A, Villarreal-Calderón A, Lyght O, Janszen D, Morgan KT. Nasal epithelium as a sentinel for airborne environmental pollution. Toxicol Sci. 1998;46(2):352–64. doi:10.1093/toxsci/46.2.352.CrossRefPubMed

37.

Shusterman D. The effects of air pollutants and irritants on the upper airway. Proc Am Thorac Soc. 2011;8(1):101–5. doi:10.1513/pats.201003-027RN.CrossRefPubMed

38.

Gowers AM, Cullinan P, Ayres JG, Anderson HR, Strachan DP, Holgate ST, et al. Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review. Respirology. 2012;17(6):887–98. doi:10.1111/j.1440-1843.2012.02195.x.CrossRefPubMed

39.

Guarnieri M, Balmes JR. Outdoor air pollution and asthma. Lancet. 2014;383(9928):1581–92. doi:10.1016/s0140-6736(14)60617-6.CrossRefPubMedPubMedCentral

40.

Huang SK, Zhang Q, Qiu Z, Chung KF. Mechanistic impact of outdoor air pollution on asthma and allergic diseases. J Thorac Dis. 2015;7(1):23–33. doi:10.3978/j.issn.2072-1439.2014.12.13.PubMedPubMedCentral

41.

Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002;110(3):349–56. doi:10.1067/mai.2002.126780.CrossRefPubMed

42.

Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88. doi:10.1146/annurev.pharmtox.45.120403.095857.CrossRefPubMed

43.

Kelly F. Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med. 2003;60(8):612–6.CrossRefPubMedPubMedCentral

44.

Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007;2(2):219–36.PubMedPubMedCentral

45.

Holguin F. Oxidative stress in airway diseases. Ann Am Thorac Soc. 2013;10(Suppl):S150–7. doi:10.1513/AnnalsATS.201305-116AW.CrossRefPubMed

46.

Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J. 2000;16(3):534–54.CrossRefPubMed

47.

Lodovici M, Bigagli E. Oxidative stress and air pollution exposure. J Toxicol. 2011;2011:487074. doi:10.1155/2011/487074.CrossRefPubMedPubMedCentral

48.

Brauer M. How much, how long, what, and where: air pollution exposure assessment for epidemiologic studies of respiratory disease. Proc Am Thorac Soc. 2010;7(2):111–5.CrossRefPubMed

49.

Künzli N, Mudway IS, Götschi T, Shi T, Kelly FJ, Cook S, et al. Comparison of oxidative properties, light absorbance, and total and elemental mass concentration of ambient PM(2.5) collected at 20 European sites. Environ Health Perspect. 2006;114(5):684–90. doi:10.1289/ehp.8584.CrossRefPubMed

50.

Smith PG, Day NE. The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol. 1984;13(3):356–65.CrossRefPubMed

51.

Weichenthal SA, Lavigne E, Evans GJ, Godri Pollitt KJ, Burnett RT. Fine particulate matter and emergency room visits for respiratory illness. Effect modification by oxidative potential. Am J Respir Crit Care Med. 2016;194(5):577–86. doi:10.1164/rccm.201512-2434OC.CrossRefPubMed

Titel: Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies
verfasst von: Gayan Bowatte
Caroline J. Lodge
Jennifer L. Perret
Melanie C. Matheson
Shyamali C. Dharmage
Publikationsdatum: 01.11.2016
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 12/2016
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-016-0664-z

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies

Abstract

Purpose of Review

Recent Findings

Summary

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

RRP: Adjuvante HPV-Impfung in jedem Alter empfehlenswert

Update HNO

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2016

Lupin and Other Potentially Cross-Reactive Allergens in Peanut Allergy

Benefit of SLIT and SCIT for Allergic Rhinitis and Asthma

Epigenetic Changes During Food-Specific Immunotherapy

Fungal Exposure and Asthma: IgE and Non-IgE-Mediated Mechanisms

Childcare and School Management Issues in Food Allergy

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

RRP: Adjuvante HPV-Impfung in jedem Alter empfehlenswert

Update HNO