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01.03.2018 | Allergies and the Environment (M Hernandez, Section Editor)

Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

verfasst von: Xin Dai, Gayan Bowatte, Adrian J. Lowe, Melanie C. Matheson, Lyle C. Gurrin, John A. Burgess, Shyamali C. Dharmage, Caroline J. Lodge

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 3/2018

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Abstract

Purpose of Review

Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function.

Recent Findings

Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. However, findings differed in terms of risk alleles and specific exposures. High-exposure heterogeneity precluded meta-analysis.

Summary

We found evidence that respiratory effects of indoor air pollution depend on the individual’s GST profile. This may help explain the inconsistent associations found when gene-environment interactions are not considered. Future studies should aim to improve the accuracy of pollution assessment and investigate this finding in different populations.

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Titel: Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review
verfasst von: Xin Dai
Gayan Bowatte
Adrian J. Lowe
Melanie C. Matheson
Lyle C. Gurrin
John A. Burgess
Shyamali C. Dharmage
Caroline J. Lodge
Publikationsdatum: 01.03.2018
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 3/2018
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-018-0771-0

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Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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