nach oben

01.06.2015 | Women and Ischemic Heart Disease (M Gulati, Section Editor)

PAD in Women: the Ischemic Continuum

Erschienen in: Current Atherosclerosis Reports | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

Lower extremity peripheral arterial disease (PAD) is part of the ischemic continuum of atherosclerotic vascular disease and is associated with an increased risk of myocardial infarction, stroke, and cardiovascular death. Compared to men, women with PAD are more likely to have asymptomatic disease or atypical symptoms. PAD in women is associated with decreased exercise capacity, reduced quality of life, increased risk of depression, as well as a greater risk of acute cardiovascular events and cardiovascular mortality than male counterparts. Ensuring an appropriate diagnosis of women with PAD offers an opportunity to begin risk factor modification therapy, improve walking capacity and make a timely referral for revascularization if needed. It is critical to highlight the sex-based disparities in lower extremity PAD so that we may work to improve outcomes for women with PAD.

Go AS, Mozaffarian D, Roger VL, et al. Executive summary: heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation. 2013;127:143–52.CrossRefPubMed

Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000. Circulation. 2004;110:738–43.CrossRefPubMed

Hirsch AT, Allison MA, Gomes AS, et al. A call to action: women and peripheral artery disease: a scientific statement from the American Heart Association. Circulation. 2012;125:1449–72.CrossRefPubMed

Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127:1425–43.CrossRefPubMed

Aboyans V, Criqui MH, Abraham P, et al. Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association. Circulation. 2012;126:2890–909.CrossRefPubMed

Huxley RR, Woodward M. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet. 2011;378:1297–305.CrossRefPubMed

Lu L, Mackay DF, Pell JP. Meta-analysis of the association between cigarette smoking and peripheral arterial disease. Heart. 2014;100:414–23.CrossRefPubMed

Maeda Y, Inoguchi T, Etoh E, et al. Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: the Kyushu Prevention Study of Atherosclerosis. Diabetes Care. 2014;37:2383–90.CrossRefPubMed

Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. J Vasc Surg. 2014;60:396–403.CrossRefPubMedCentralPubMed

10.

Sigvant B, Wiberg-Hedman K, Bergqvist D, et al. A population- based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences. J Vasc Surg. 2007;45:1185–91.

11.

Sigvant B, Lundin F, Nilsson B, et al. Differences in presentation of symptoms between women and men with intermittent claudication. BMC Cardiovasc Disord. 2011;11:39.

12.

Gardner AW, Parker DE, Montgomery PS, et al. Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. J Vasc Surg. 2014. doi:10.1016/j.jvs.2014.02.045.PubMedCentral

13.

Andras A, Ferket B. Screening for peripheral arterial disease. Cochrane Database Syst Rev. 2014;4, CD010835.PubMed

14.

Moyer VA, U.S. Preventive Services Task Force. Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;159:I–28.CrossRef

15.

Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2889–934.CrossRefPubMed

16.

Ankle Brachial Index Collaboration, Fowkes FG, Murray GD, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300:197–208.CrossRefPubMedCentral

17.

Diehm C, Allenberg JR, Pittrow D, et al. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation. 2009;120:2053–61.CrossRefPubMed

18.

Hirsch AT, Criqui MH, Treat-Jacobson D, et al. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286:1317–24.CrossRefPubMed

19.

McDermott MM, Greenland P, Liu K, et al. Sex differences in peripheral arterial disease: leg symptoms and physical functioning. J Am Geriatr Soc. 2003;51:222–8.CrossRefPubMed

20.

McDermott MM, Fried L, Simonsick E, Ling S, Guralnik JM. Asymptomatic peripheral arterial disease is independently associated with impaired lower extremity functioning: the women’s health and aging study. Circulation. 2000;101:1007–12.CrossRefPubMed

21.

Gardner AW. Sex differences in claudication pain in subjects with peripheral arterial disease. Med Sci Sports Exerc. 2002;34:1695–8.CrossRefPubMed

22.

Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. J Vasc Surg. 2010;52:637–44.CrossRefPubMed

23.

Szuba A, Oka RK, Harada R, Cooke JP. Limb hemodynamics are not predictive of functional capacity in patients with PAD. Vasc Med. 2006;11:155–63.CrossRefPubMed

24.

Grenon SM, Chong K, Alley H, et al. Walking disability in patients with peripheral artery disease is associated with arterial endothelial function. J Vasc Surg. 2014;59:1025–34.CrossRefPubMedCentralPubMed

25.

Chen Q, Shi Y, Wang Y, Li X. Patterns of disease distribution of lower extremity peripheral arterial disease. Angiology. 2015. doi:10.1177/0003319714525831.

26.

Ambrosetti M, Temporelli PL, Faggiano P, et al. Lower extremities peripheral arterial disease among patients admitted to cardiac rehabilitation: the THINKPAD registry. Int J Cardiol. 2014;171:192–8.CrossRefPubMed

27.

Armstrong EJ, Chen DC, Westin GG, et al. Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease. J Am Heart Assoc. 2014;3, e000697.CrossRefPubMedCentralPubMed

28.

Antithrombotic TC. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71–86.CrossRef

29.

Wong PF, Chong LY, Stansby G. Antiplatelet therapy to prevent cardiovascular events and mortality in patients with intermittent claudication. JAMA. 2013;309:926–7.CrossRefPubMed

30.

Vaidya A, Joore MA, Ten Cate-Hoek AJ, Ten Cate H, Severens JL. Screen or not to screen for peripheral arterial disease: guidance from a decision model. BMC Public Health. 2014;14:89.CrossRefPubMedCentralPubMed

31.

Steenhof N, Le Piane F, Leblanc K, et al. Vascular quality of care pilot study: how admission to a vascular surgery service affects evidence-based pharmacologic risk factor modification in patients with lower extremity peripheral arterial disease. Vasc Health Risk Manag. 2014;10:333–40.CrossRefPubMedCentralPubMed

32.

Sharma S, Thapa R, Jeevanantham V, et al. Comparison of lipid management in patients with coronary versus peripheral arterial disease. Am J Cardiol. 2014;113:1320–5.CrossRefPubMed

33.

Jackson EA, Munir K, Schreiber T, et al. Impact of sex on morbidity and mortality rates after lower extremity interventions for peripheral arterial disease: observations from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. J Am Coll Cardiol. 2014;63:2525–30.CrossRefPubMed

34.

Cacoub PP, Abola MT, Baumgartner I, et al. Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry. Atherosclerosis. 2009;204:e86–92.CrossRefPubMed

35.

Karnabatidis D, Spiliopoulos S, Pastromas G, et al. Prevalence of nonresponsiveness to aspirin in patients with symptomatic peripheral arterial disease using true point of care testing. Cardiovasc Intervent Radiol. 2014;37:631–8.CrossRefPubMed

36.

Ruiz-Canela M, Estruch R, Corella D, Salas-Salvado J, Martinez-Gonzalez MA. Association of Mediterranean diet with peripheral artery disease: the PREDIMED randomized trial. JAMA. 2014;311:415–7.CrossRefPubMed

37.

Parmenter BJ, Dieberg G, Smart NA. Exercise training for management of peripheral arterial disease: a systematic review and meta-analysis. Sports Med. 2015;45:231–44.CrossRefPubMed

38.

McDermott MM, Liu K, Guralnik JM, et al. Home-based walking exercise intervention in peripheral artery disease: a randomized clinical trial. JAMA. 2013;310:57–65.CrossRefPubMed

39.

Murphy TP, Cutlip DE, Regensteiner JG, et al. Supervised exercise versus primary stenting for claudication resulting from aortoiliac peripheral artery disease: six-month outcomes from the claudication: exercise versus endoluminal revascularization (CLEVER) study. Circulation. 2012;125:130–9.CrossRefPubMedCentralPubMed

40.

Gardner AW, Parker DE, Montgomery PS, Blevins SM. Diabetic women are poor responders to exercise rehabilitation in the treatment of claudication. J Vasc Surg. 2014;59:1036–43.CrossRefPubMedCentralPubMed

41.

Lo RC, Bensley RP, Dahlberg SE, et al. Presentation, treatment, and outcome differences between men and women undergoing revascularization or amputation for lower extremity peripheral arterial disease. J Vasc Surg. 2014;59:409–18.CrossRefPubMedCentralPubMed

42.

Wisman PP, Tangelder MJ, van Hattum ES, de Borst GJ, Moll FL. Young women with PAD are at high risk of cardiovascular complications. Eur J Vasc Endovasc Surg. 2012;43:441–5.CrossRefPubMed

Titel: PAD in Women: the Ischemic Continuum
Publikationsdatum: 01.06.2015
Erschienen in: Current Atherosclerosis Reports / Ausgabe 6/2015
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-015-0513-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

PAD in Women: the Ischemic Continuum

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin