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Current Cardiology Reports

Erschienen in:

01.01.2015 | Nuclear Cardiology (V Dilsizian, Section Editor)

FDG PET Imaging for Identifying Pulmonary Hypertension and Right Heart Failure

verfasst von: Ali Ahmadi, Hiroshi Ohira, Lisa M. Mielniczuk

Erschienen in: Current Cardiology Reports | Ausgabe 1/2015

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Abstract

Pulmonary arterial hypertension (PAH) is a syndrome characterized by lung vascular intimal lesions, smooth muscle layer hypertrophy, perivascular inflammation, and concomitant right ventricular (RV) remodeling which can ultimately lead to the RV function decline known as RV failure (RVF). A key determining factor for RVF development is the RV metabolic state defined by the level of ischemia and glycolysis which constitute a vicious cycle of hypoxia, metabolic shift from glucose oxidation (GO) to glycolysis, increased RV systolic pressure (RVSP), decreased RV output, and further myocardial ischemia. In this context, 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) positron emission tomography (PET) has been used for the measurement of glucose uptake (GU) as an indicator of glucose metabolism in the right heart and pulmonary vasculature. The focus of this review is the application of FDG PET modality for assessing PAH severity and clinical outcome.

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Titel: FDG PET Imaging for Identifying Pulmonary Hypertension and Right Heart Failure
verfasst von: Ali Ahmadi
Hiroshi Ohira
Lisa M. Mielniczuk
Publikationsdatum: 01.01.2015
Verlag: Springer US
Erschienen in: Current Cardiology Reports / Ausgabe 1/2015
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-014-0555-7

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FDG PET Imaging for Identifying Pulmonary Hypertension and Right Heart Failure

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