Erschienen in:
01.07.2015 | Diabetes and Cardiovascular Disease (S Malik, Section Editor)
Predicting Cardiovascular Risk in Type 2 Diabetes: the Heterogeneity Challenges
verfasst von:
M. Odette Gore, Darren K. McGuire, Ildiko Lingvay, Julio Rosenstock
Erschienen in:
Current Cardiology Reports
|
Ausgabe 7/2015
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Abstract
Type 2 diabetes mellitus has reached epidemic proportions around the world, and the increase in cardiovascular risk attributable to diabetes estimated to range from 2- to 4-fold poses grave public health concern. Though in some contexts type 2 diabetes has been equated with coronary heart disease equivalent risk, there is considerable evidence that incremental cardiovascular risk does not uniformly affect all people with type 2 diabetes. This heterogeneity in cardiovascular risk is multifactorial and only partially understood but is a key consideration for our understanding of the nexus of diabetes and cardiovascular disease and for the development of optimal and individualized cardiovascular risk reduction strategies. This review provides a brief synopsis of the concept of cardiovascular risk heterogeneity in diabetes, including epidemiologic evidence, discussion of established and potential determinants of heterogeneity, and clinical, research, and regulatory implications.