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Current Cardiology Reports

Erschienen in:

01.08.2017 | Myocardial Disease (A Abbate, Section Editor)

Adverse Remodeling and Reverse Remodeling After Myocardial Infarction

verfasst von: Ankeet S. Bhatt, Andrew P. Ambrosy, Eric J. Velazquez

Erschienen in: Current Cardiology Reports | Ausgabe 8/2017

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Abstract

Purpose of Review

The purpose of this review it to summarize the current literature on remodeling after myocardial infarction, inclusive of pathophysiological considerations, imaging modalities, treatment strategies, and future directions.

Recent Findings

As patients continue to live longer after myocardial infarction (MI), the prevalence of post-MI heart failure continues to rise. Changes in the left ventricle (LV) after MI involve complex interactions between cellular and extracellular components, under neurohormonal regulation. Treatments to prevent adverse LV remodeling and promote reverse remodeling in the post-MI setting include early revascularization, pharmacotherapy aimed at neurohormonal blockade, and device-based therapies that address ventricular dyssynchrony.

Summary

Despite varying definitions of adverse LV remodeling examined across multiple imaging modalities, the presence of an enlarged LV cavity and/or reduced ejection fraction is consistently associated with poor clinical outcomes. Advances in our knowledge of the neurohormonal regulation of adverse cardiac remodeling have been instrumental in generating therapies aimed at arresting adverse remodeling and promoting reserve remodeling. Further investigation into other specific mechanisms of adverse LV remodeling and pathways to disrupt these mechanisms is ongoing and may provide incremental benefit to current evidence-based therapies.

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Titel: Adverse Remodeling and Reverse Remodeling After Myocardial Infarction
verfasst von: Ankeet S. Bhatt
Andrew P. Ambrosy
Eric J. Velazquez
Publikationsdatum: 01.08.2017
Verlag: Springer US
Erschienen in: Current Cardiology Reports / Ausgabe 8/2017
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-017-0876-4

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Adverse Remodeling and Reverse Remodeling After Myocardial Infarction

Abstract

Purpose of Review

Recent Findings

Summary

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Abstract

Purpose of Review

Recent Findings

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