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Erschienen in: Current Diabetes Reports 8/2015

01.08.2015 | Microvascular Complications—Nephropathy (T Isakova, Section Editor)

Weight Loss Interventions and Progression of Diabetic Kidney Disease

verfasst von: Neil G. Docherty, Aoife L. Canney, Carel W. le Roux

Erschienen in: Current Diabetes Reports | Ausgabe 8/2015

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Abstract

Progressive renal impairment (diabetic kidney disease (DKD)) occurs in upwards of 40 % of patients with obesity and type 2 diabetes mellitus (T2DM) and is a cause of significant morbidity and mortality. Means of attenuating the progression of DKD focus on amelioration of risk factors. Visceral obesity is implicated as a causative agent in impaired metabolic and cardiovascular control in T2DM, and various approaches primarily targeting weight have been examined for their impact on markers of renal injury and dysfunction in DKD. The current report summarises the evidence base for the impact of surgical, lifestyle and pharmacological approaches to weight loss on renal end points in DKD. The potential for a threshold of weight loss more readily achievable by surgical intervention to be a prerequisite for renal improvement is highlighted. Comparing efficacious non-surgical weight loss strategies with surgical strategies in appropriately powered and controlled prospective studies is a priority for the field.
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Metadaten
Titel
Weight Loss Interventions and Progression of Diabetic Kidney Disease
verfasst von
Neil G. Docherty
Aoife L. Canney
Carel W. le Roux
Publikationsdatum
01.08.2015
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 8/2015
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-015-0625-2

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